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626-64-2

Basic Information
CAS No.: 626-64-2
Name: 4-Hydroxypyridine
Molecular Structure:
Molecular Structure of 626-64-2 (4-Hydroxypyridine)
Formula: C5H5NO
Molecular Weight: 95.1
Synonyms: 5-21-07-00152 (Beilstein Handbook Reference);4-Pyridinol;gamma-Hydroxypyridine;1H-Pyridin-4-one;4-hydropyridine;Pyridin-4-ol;
EINECS: 210-958-3
Density: 1.111 g/cm3
Melting Point: 150-151 °C(lit.)
Boiling Point: 204.3 °C at 760 mmHg
Flash Point: 107.8 °C
Solubility: soluble in water
Appearance: beige crystalline powder
Hazard Symbols: IrritantXi
Risk Codes: 36/37/38
Safety: 26-36-37/39
Transport Information:
PSA: 33.12000
LogP: 0.78720
Synthetic route
1692-15-5

4-pyridylboronic acid

626-64-2

pyridin-4-ol

Conditions
ConditionsYield
With fullerene (C60); oxygen; N-ethyl-N,N-diisopropylamine In ethanol; toluene Irradiation; Flow reactor;99%
With water; oxygen; sodium sulfite at 50℃; for 1h; Green chemistry;90%
With dihydrogen peroxide In ethanol at 20℃; for 0.166667h;79%
1338215-40-9

4-(2-trimethylsilanylethoxy)pyridine

626-64-2

pyridin-4-ol

Conditions
ConditionsYield
Stage #1: 4-(2-trimethylsilanylethoxy)pyridine With cesium fluoride In N,N-dimethyl-formamide at 60℃; for 1h; Inert atmosphere;
Stage #2: With water In N,N-dimethyl-formamide Inert atmosphere;
95%

3,5-dichloropiperidin-4-one

626-64-2

pyridin-4-ol

Conditions
ConditionsYield
With potassium carbonate In tetrahydrofuran at 40 - 45℃; for 3h;93.3%
620-08-6

4-methoxypyridine

626-64-2

pyridin-4-ol

Conditions
ConditionsYield
With L-Selectride In tetrahydrofuran for 2h; Reagent/catalyst; Solvent; Reflux; Inert atmosphere; chemoselective reaction;87%
With toluene-4-sulfonic acid; lithium chloride In 1-methyl-pyrrolidin-2-one at 180℃; for 1h;85%
With hexamethyldisilathiane; sodium methylate In various solvent(s) at 180℃; for 24h;60%
1417816-42-2

benzyl 4-pyridyl carbonate

626-64-2

pyridin-4-ol

Conditions
ConditionsYield
With methanol; sodium tetrahydroborate; nickel(II) chloride hexahydrate at 20℃; for 0.25h; chemoselective reaction;81%
1692-15-5

4-pyridylboronic acid

626-64-2

pyridin-4-ol

Conditions
ConditionsYield
With triethanolamine In water at 20℃; for 18h; Sonication; Irradiation; Green chemistry;76%
15854-87-2

4-iodopyridine

626-64-2

pyridin-4-ol

Conditions
ConditionsYield
With copper(I) oxide; 2-pyridinealdoxime; cesium hydroxide; tetrabutylammomium bromide In water at 110℃; for 48h; Inert atmosphere;73%
With oxygen; triethylamine In acetonitrile at 32℃; for 24h; Schlenk technique; UV-irradiation;39%
Multi-step reaction with 2 steps
1.1: copper(l) iodide; 1,10-Phenanthroline; caesium carbonate / toluene / 14 h / 110 °C / Inert atmosphere; Sealed tube
2.1: cesium fluoride / N,N-dimethyl-formamide / 1 h / 60 °C / Inert atmosphere
2.2: Inert atmosphere
View Scheme

C7H9NO2

626-64-2

pyridin-4-ol

Conditions
ConditionsYield
With L-Selectride In tetrahydrofuran for 48h; Reflux; chemoselective reaction;57%
40504-49-2

4-allyloxy-pyridine

626-64-2

pyridin-4-ol

Conditions
ConditionsYield
With L-Selectride In tetrahydrofuran for 48h; Reflux; chemoselective reaction;57%
513-81-5

2,3-dimethyl-buta-1,3-diene

178620-85-4

4-pyridyl phenacyl sulfoxide

A

626-64-2

pyridin-4-ol

B

80738-10-9

2-Benzoyl-3,6-dihydro-4,5-dimethyl-2H-thiopyran

Conditions
ConditionsYield
In 1,4-dioxane at 100℃; for 24h;A n/a
B 36%

C13H13NO2

626-64-2

pyridin-4-ol

Conditions
ConditionsYield
With L-Selectride In tetrahydrofuran for 48h; Reflux; chemoselective reaction;20%
49826-70-2

4-(benzyloxy)pyridine

626-64-2

pyridin-4-ol

Conditions
ConditionsYield
With L-Selectride In tetrahydrofuran for 48h; Reflux; chemoselective reaction;19%
With (4,4'-di-tert-butyl-2,2'-dipyridyl)-bis-(2-phenylpyridine(-1H))-iridium(III) hexafluorophosphate; ascorbic acid In water; acetonitrile at 20℃; for 21h; Schlenk technique; Irradiation; Inert atmosphere; chemoselective reaction;0.0188 g
33399-46-1

4-ethoxypyridine

626-64-2

pyridin-4-ol

Conditions
ConditionsYield
With L-Selectride In tetrahydrofuran for 48h; Reflux; chemoselective reaction;11%
110-86-1

pyridine

A

626-64-2

pyridin-4-ol

B

553-26-4

4,4'-bipyridine

Conditions
ConditionsYield
With oxygen; trifluoroacetic anhydride for 72h; Ambient temperature;A 0.18%
B 2.3%
108-97-4

4-pyrone

626-64-2

pyridin-4-ol

Conditions
ConditionsYield
With ammonia
With ammonia at 120 - 140℃;
504-24-5

4-aminopyridine

626-64-2

pyridin-4-ol

Conditions
ConditionsYield
With sulfuric acid Diazotization;
626-61-9

4-Chloropyridine

626-64-2

pyridin-4-ol

Conditions
ConditionsYield
Destillation;
6890-62-6

4-hydroxypyridine N-oxide

626-64-2

pyridin-4-ol

Conditions
ConditionsYield
With hydrogenchloride; palladium on activated charcoal; ethanol; water Hydrogenation;
With methanol; nickel at 120℃; under 51485.6 Torr; Hydrogenation;
With 1,4-dioxane; phosphorus trichloride
With acetic anhydride; ethyl acetate
With palladium on activated charcoal; ethanol Hydrogenation;
2683-66-1

4-benzyloxypyridine-N-oxide

626-64-2

pyridin-4-ol

Conditions
ConditionsYield
With methanol; palladium on activated charcoal; nickel Hydrogenation;
With palladium on activated charcoal; ethanol Hydrogenation;
5421-92-1

1-(4-pyridyl)pyridinium chloride hydrochloride

626-64-2

pyridin-4-ol

Conditions
ConditionsYield
With water
110-86-1

pyridine

A

109-00-2

3-HYDROXYPYRIDINE

B

142-08-5

2-hydroxypyridin

C

626-64-2

pyridin-4-ol

Conditions
ConditionsYield
With nitrous oxide saturated solution; hexachloroiridate(IV) Product distribution; Irradiation; in presence and absence of var. oxidants ;
108-96-3

4-pyridone

626-64-2

pyridin-4-ol

Conditions
ConditionsYield
In chloroform Equilibrium constant; Ambient temperature;
In water at 20℃; Equilibrium constant; polar - non-polar tautomer equilibrium;
In gaseous matrix Thermodynamic data; Equilibrium constant; ΔRGo, ΔRH, tests in solvents of different polarity;
36228-61-2

4-(Benzoyloxy)pyridine

A

626-64-2

pyridin-4-ol

B

65-85-0

benzoic acid

Conditions
ConditionsYield
With potassium hydroxide In water; acetonitrile at 25℃; Rate constant; k=200 sec-1M-1;
4-oxy-pyridine-carboxylic acid-(2)

4-oxy-pyridine-carboxylic acid-(2)

626-64-2

pyridin-4-ol

Conditions
ConditionsYield
ueber den Schmelzpunkt;
4-oxy-pyridine-carboxylic acid-(3)

4-oxy-pyridine-carboxylic acid-(3)

626-64-2

pyridin-4-ol

Conditions
ConditionsYield
at 260℃;
4-oxy-pyridine-dicarboxylic acid-(2.6)

4-oxy-pyridine-dicarboxylic acid-(2.6)

626-64-2

pyridin-4-ol

Conditions
ConditionsYield
at 230 - 250℃;
With water at 196℃;
4-oxy-pyridine-dicarboxylic acid-(3.5)

4-oxy-pyridine-dicarboxylic acid-(3.5)

626-64-2

pyridin-4-ol

Conditions
ConditionsYield
With hydrogenchloride at 210 - 215℃;
101349-88-6

1-hydroxy-1H-pyridin-4-one

67-66-3

chloroform

7719-12-2, 52843-90-0

phosphorus trichloride

626-64-2

pyridin-4-ol

<1,4'>bipyridylium bromide hydrobromide

<1,4'>bipyridylium bromide hydrobromide

626-64-2

pyridin-4-ol

Conditions
ConditionsYield
With water
626-64-2

pyridin-4-ol

5382-16-1

4-HYDROXYPIPERIDINE

Conditions
ConditionsYield
In methanol; water100%
With water; ruthenium Hydrogenation;
With water; pyrographite; ruthenium at 140℃; under 87525.4 Torr; Hydrogenation;
With hydrogenchloride; 5% active carbon-supported ruthenium; hydrogen In water at 95℃; under 26252.6 Torr; for 24h; Reagent/catalyst; Time; Autoclave;99.5 %Chromat.
With palladium on activated charcoal; hydrogen; acetic acid at 20℃; under 760.051 Torr; for 21h; Time;55 %Spectr.
626-64-2

pyridin-4-ol

25813-25-6

3,5-dibromo-4-hydroxypyridine

Conditions
ConditionsYield
With N-Bromosuccinimide In tetrachloromethane at 20℃; for 24h;100%
With N-Bromosuccinimide In tetrachloromethane at 20℃; for 24h;95%
With N-Bromosuccinimide In tetrachloromethane at 25℃; for 30h; Inert atmosphere;88%
626-64-2

pyridin-4-ol

350-46-9

4-Fluoronitrobenzene

79228-85-6

1-(4-nitrophenyl)-4-pyridone

Conditions
ConditionsYield
With potassium carbonate In 1-methyl-pyrrolidin-2-one at 110℃; for 1.5h; Substitution;100%
With caesium carbonate In DMF (N,N-dimethyl-formamide)
With caesium carbonate In N,N-dimethyl-formamide
626-64-2

pyridin-4-ol

88-88-0

2,4,6-trinitrochlorobenzene

N-(2,4,6-trinitrophenyl)-4-pyridone

Conditions
ConditionsYield
In acetonitrile at 30℃; Product distribution; Kinetics; Further Variations:; Solvents;100%
626-64-2

pyridin-4-ol

(3R,4R)-3-{(R)-1-[(tert-butyldimethylsilyl)oxy]ethyl}-4-(pyridin-4-yloxy)azetidin-2-one

Conditions
ConditionsYield
With triethylamine In water; acetonitrile for 1h;100%
626-64-2

pyridin-4-ol

942152-80-9

7-bromo-4-hydroxy-1-methyl-2-oxo-1,2-dihydroquinoline-3-carboxylic acid methyl ester

4-hydroxy-1-methyl-2-oxo-7-(pyridin-4-yloxy)-1,2-dihydroquinoline-3-carboxylic acid methyl ester

Conditions
ConditionsYield
With copper(l) iodide; dimethylaminoacetic acid; caesium carbonate In N,N-dimethyl-formamide at 140℃; for 12h; Inert atmosphere;100%
626-64-2

pyridin-4-ol

109384-19-2

t-butyl 4-hydroxy piperidine-1-carboxylate

308386-35-8

1,1-dimethylethyl 4-(4'-pyridinyloxy)-1-piperidinecarboxylate

Conditions
ConditionsYield
With di-isopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran at 0℃;99%
75%
With di-isopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran at 55℃; for 14h; Mitsunobu reaction;67%
626-64-2

pyridin-4-ol

548770-64-5

methyl-phenyl-carbamic acid 4-(2-hydroxy-ethyl)-phenyl ester

811435-86-6

methyl-phenyl-carbamic acid 4-[2-(pyridin-4-yloxy)-ethyl]-phenyl ester

Conditions
ConditionsYield
With tributylphosphine; N-ethyl-N,N-diisopropylamine; 1,1'-azodicarbonyl-dipiperidine In tetrahydrofuran at 20℃; for 16h;99%
626-64-2

pyridin-4-ol

663164-11-2

chloro(2,6-bis(dimethylaminomethyl)phenyl-N,C,N)platinum(II)

881887-98-5

[2,6-bis(dimethylaminomethyl)phenylplatinum]-4-pyridone

Conditions
ConditionsYield
With sodium hydroxide In ethanol under N2 atm. Pt complex, 4-hydroxypyridine, and NaOH in EtOH were stirred for 2 h; solvent was evapd. in vacuo, residue was dissolved in CH2Cl2 in air and filtered, filtrate was evapd.; elem. anal.;99%
626-64-2

pyridin-4-ol

134450-56-9

4,5-difluoro-1,2-dicyanobenzene

4,5-bis(4-oxopyridin-1(4H)-yl)phthalonitrile

Conditions
ConditionsYield
With triethylamine In N,N-dimethyl-formamide at 80℃; for 5h; Inert atmosphere;99%
626-64-2

pyridin-4-ol

948859-48-1

1-(4-fluorophenyl)prop-2-ynyl acetate

C14H10FNO

Conditions
ConditionsYield
With C24H18F2N2O2; N-ethyl-N,N-diisopropylamine; copper(l) chloride In chloroform; 2,2,2-trifluoroethanol at -40℃; for 60h; Inert atmosphere; Schlenk technique; enantioselective reaction;99%
626-64-2

pyridin-4-ol

1191267-32-9

1-(3-methylphenyl)-2-propynyl acetate

C15H13NO

Conditions
ConditionsYield
With C24H18F2N2O2; N-ethyl-N,N-diisopropylamine; copper(l) chloride In chloroform; 2,2,2-trifluoroethanol at -40℃; for 60h; Inert atmosphere; Schlenk technique; enantioselective reaction;99%
626-64-2

pyridin-4-ol

1015083-64-3

1-(3,4-dimethoxyphenyl)prop-2-ynyl acetate

C16H15NO3

Conditions
ConditionsYield
With C24H18F2N2O2; N-ethyl-N,N-diisopropylamine; copper(l) chloride In chloroform; 2,2,2-trifluoroethanol at -40℃; for 60h; Inert atmosphere; Schlenk technique; enantioselective reaction;99%
626-64-2

pyridin-4-ol

1240238-60-1

1-(2-methylphenyl)-2-propynyl acetate

C15H13NO

Conditions
ConditionsYield
With C24H18F2N2O2; N-ethyl-N,N-diisopropylamine; copper(l) chloride In chloroform; 2,2,2-trifluoroethanol at -40℃; for 60h; Inert atmosphere; Schlenk technique; enantioselective reaction;99%
626-64-2

pyridin-4-ol

952686-35-0

methyl p-methylphenylallyl carbonate

C15H15NO

Conditions
ConditionsYield
With bis(1,5-cyclooctadiene)diiridium(I) dichloride; 1,3,4,6,7,8-hexahydro-2H-pyrimido[1,2-a]pyrimidine; 1,8-diazabicyclo[5.4.0]undec-7-ene; (3,5-Dioxa-4-phospha-cyclohepta[2,1-a;3,4-a']dinaphthalen-4-yl)-bis-((R)-1-phenyl-ethyl)-amine In tetrahydrofuran at 50℃; for 8h; Inert atmosphere; stereoselective reaction;99%
626-64-2

pyridin-4-ol

952686-36-1

p-bromophenylpropene methyl carbonate

C14H12BrNO

Conditions
ConditionsYield
With bis(1,5-cyclooctadiene)diiridium(I) dichloride; 1,3,4,6,7,8-hexahydro-2H-pyrimido[1,2-a]pyrimidine; 1,8-diazabicyclo[5.4.0]undec-7-ene; (3,5-Dioxa-4-phospha-cyclohepta[2,1-a;3,4-a']dinaphthalen-4-yl)-bis-((R)-1-phenyl-ethyl)-amine In tetrahydrofuran at 50℃; for 8h; Inert atmosphere; stereoselective reaction;99%
626-64-2

pyridin-4-ol

(1r,3r)-3-(benzyloxy)cyclobutan-1-ol

4-[(1s,3s)-(3-benzyloxy)cyclobutoxy]pyridine

Conditions
ConditionsYield
With di-isopropyl azodicarboxylate; triphenylphosphine In toluene at 110℃; Temperature; Solvent;99%
626-64-2

pyridin-4-ol

24424-99-5

di-tert-butyl dicarbonate

109384-19-2

t-butyl 4-hydroxy piperidine-1-carboxylate

Conditions
ConditionsYield
Stage #1: pyridin-4-ol With chloro(1,5-cyclooctadiene)rhodium(I) dimer; borane-ammonia complex In 2,2,2-trifluoroethanol at 50℃; for 24h; Inert atmosphere; Schlenk technique; Sealed tube;
Stage #2: di-tert-butyl dicarbonate With triethylamine In 2,2,2-trifluoroethanol at 20℃; Inert atmosphere; Schlenk technique; Sealed tube;
99%
626-64-2

pyridin-4-ol

5435-54-1

4-hydroxy-3-nitropyridine

Conditions
ConditionsYield
With sulfuric acid; potassium nitrate at 0 - 100℃; for 1h; Inert atmosphere;98%
With fuming sulphuric acid; nitric acid for 2h; Reflux;92%
With sulfuric acid; potassium nitrate at 100℃;92%
626-64-2

pyridin-4-ol

2398-37-0

3-methoxyphenyl bromide

1-(3-methoxyphenyl)pyridin-4(1H)-one

Conditions
ConditionsYield
With potassium carbonate; copper(l) iodide; 4,7-dimethoxy-1,10-phenanthroline In N,N-dimethyl-formamide at 110℃; for 24h;98%
626-64-2

pyridin-4-ol

947169-76-8

C15H14O3

C18H15NO

Conditions
ConditionsYield
With bis(1,5-cyclooctadiene)diiridium(I) dichloride; 1,3,4,6,7,8-hexahydro-2H-pyrimido[1,2-a]pyrimidine; 1,8-diazabicyclo[5.4.0]undec-7-ene; (3,5-Dioxa-4-phospha-cyclohepta[2,1-a;3,4-a']dinaphthalen-4-yl)-bis-((R)-1-phenyl-ethyl)-amine In tetrahydrofuran at 50℃; for 24h; Mechanism; Inert atmosphere; stereoselective reaction;98%
626-64-2

pyridin-4-ol

776296-22-1

3-(4-chlorophenyl)allyl methyl carbonate

C14H12ClNO

Conditions
ConditionsYield
With bis(1,5-cyclooctadiene)diiridium(I) dichloride; 1,3,4,6,7,8-hexahydro-2H-pyrimido[1,2-a]pyrimidine; 1,8-diazabicyclo[5.4.0]undec-7-ene; (3,5-Dioxa-4-phospha-cyclohepta[2,1-a;3,4-a']dinaphthalen-4-yl)-bis-((R)-1-phenyl-ethyl)-amine In tetrahydrofuran at 50℃; for 8h; Inert atmosphere; stereoselective reaction;98%
626-64-2

pyridin-4-ol

626-55-1

3-Bromopyridine

34847-11-5

1-(pyridin-3-yl)pyridin-4(1H)-one

Conditions
ConditionsYield
With potassium carbonate; copper(l) iodide; 4,7-dimethoxy-1,10-phenanthroline In dimethyl sulfoxide at 110℃; for 24h;97%
626-64-2

pyridin-4-ol

91652-00-5

4-{[6-(methacryloyloxy)hexyl]oxy}benzoic acid

C22H25NO5

Conditions
ConditionsYield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In tetrahydrofuran at 23℃;97%
626-64-2

pyridin-4-ol

1222181-25-0

m-methylphenylallyl methyl carbonate

C15H15NO

Conditions
ConditionsYield
With bis(1,5-cyclooctadiene)diiridium(I) dichloride; 1,3,4,6,7,8-hexahydro-2H-pyrimido[1,2-a]pyrimidine; 1,8-diazabicyclo[5.4.0]undec-7-ene; (3,5-Dioxa-4-phospha-cyclohepta[2,1-a;3,4-a']dinaphthalen-4-yl)-bis-((R)-1-phenyl-ethyl)-amine In tetrahydrofuran at 50℃; for 8h; Inert atmosphere; stereoselective reaction;97%
626-64-2

pyridin-4-ol

C11H10F2O3

C14H11F2NO

Conditions
ConditionsYield
With bis(1,5-cyclooctadiene)diiridium(I) dichloride; 1,3,4,6,7,8-hexahydro-2H-pyrimido[1,2-a]pyrimidine; 1,8-diazabicyclo[5.4.0]undec-7-ene; (3,5-Dioxa-4-phospha-cyclohepta[2,1-a;3,4-a']dinaphthalen-4-yl)-bis-((R)-1-phenyl-ethyl)-amine In tetrahydrofuran at 50℃; for 8h; Inert atmosphere; stereoselective reaction;97%
626-64-2

pyridin-4-ol

1186634-65-0

2-bromocinnamyl methyl carbonate

C14H12BrNO

Conditions
ConditionsYield
With bis(1,5-cyclooctadiene)diiridium(I) dichloride; 1,3,4,6,7,8-hexahydro-2H-pyrimido[1,2-a]pyrimidine; 1,8-diazabicyclo[5.4.0]undec-7-ene; (3,5-Dioxa-4-phospha-cyclohepta[2,1-a;3,4-a']dinaphthalen-4-yl)-bis-((R)-1-phenyl-ethyl)-amine In tetrahydrofuran at 50℃; for 24h; Inert atmosphere; stereoselective reaction;97%
626-64-2

pyridin-4-ol

1356240-34-0

C39H35BrN2O6

1356240-42-0

C44H39N3O7

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 80℃; for 1h;96%
626-64-2

pyridin-4-ol

99520-55-5

3-acetoxy-3-(4-methoxyphenyl)prop-1-yne

C15H13NO2

Conditions
ConditionsYield
With C24H18F2N2O2; N-ethyl-N,N-diisopropylamine; copper(l) chloride In chloroform; 2,2,2-trifluoroethanol at -40℃; for 60h; Catalytic behavior; Reagent/catalyst; Temperature; Inert atmosphere; Schlenk technique; enantioselective reaction;96%
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    4-Hydroxypyridine

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    Min.Order: 1 Kilogram

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    626-64-2

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    626-64-2

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    626-64-2

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    626-64-2

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    626-64-2

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    626-64-2

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    626-64-2

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    Product Name: 4-Hydroxypyridine CAS No.: 626-64-2 EINECS No. 210-958-3 Molecular Formula: C5H5NO Molecular Weight: 95.1 Feature: Light brown or white solid. Melting: 144-148°C ( ≤2.0°C ) Quantity: ≥99.0%

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    626-64-2

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    626-64-2

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    626-64-2

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    626-64-2

    MSDS/COA Download

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    626-64-2

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    626-64-2

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  • Casno:

    626-64-2

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    626-64-2

    4-Hydroxypyridine

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    Product Description Product website: http://www.finerchem.com/pro01en/id/1806.html Product Name 4-Hydroxypyridine CAS No. 626-64-2

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    626-64-2

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    Business Type:Lab/Research institutions

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    626-64-2

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  • Best Price 4-Hydroxypyridine CAS NO.626-64-2

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    626-64-2

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  • Casno:

    626-64-2

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    Business Type:Trading Company

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  • Casno:

    626-64-2

    4-Hydroxypyridine

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     China (Mainland)  |  Contact Details

    Business Type:Other

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    Address:No.43, Xinandu Industrial Park, East and West Lake District, Wuhan, Hubei, China

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    626-64-2

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    Business Type:Lab/Research institutions

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    626-64-2

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    Address:Building 3 of Innovation Park, East District of the National University Science Park

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    626-64-2

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    span lang="EN-US" style="font-size: 9.0pt;font-family:"Arial",sans-serif;color:#4D4D4D">As a leading manufacturer and supplier of chemicals in china, weckchem not only supply popular chemicals, but also weckchem’s r&d center off

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    626-64-2

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    626-64-2

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    1. Subsidiary of Institute of Chemistry, Henan Academy of Sciences, national research platform;2. About 30 years’ experience in this field since 1983;3. An experienced R&D team consisting of Doctors and Masters;4. Various types of analytical instrume

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    Business Type:Lab/Research institutions

    Tel:+86-371-65511936

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    626-64-2

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    Business Type:Other

    Tel:+86-571-85829053

    Address:Rm A606, Fuyi Center, jianqiao street, Jianggan Area

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    626-64-2

    4-Hydroxypyridine

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    Triumph International Development Limilted is engaged in the API, pharmaceutical intermediates research and developmen.Adhering to the "customer first" business philosophy,we suppl

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    626-64-2

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    Business Type:Lab/Research institutions

    Tel:18369939125

    Address:95A, Xingyuan East Road, Zhangdian District

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  • 4-Hydroxypyridine

  • Casno:

    626-64-2

    4-Hydroxypyridine

    Min.Order: 1 Gram

    FOB Price:  USD $ 1.0-1.0/Gram

    The company is a high-tech enterprise providing comprehensive customer service for pharmaceutical companies at home and abroad in accordance with international standards. Our business includes research, development, process optimization and product

    Prime Molecular Co., Ltd. is an advanced chemical intermediates manufacture with ?two R&D centers and two production sites in China, all well-equipped with dedicated and profession

  •  PRIME MOLECULAR CO.,LIMITED

    China (Mainland)  |  Contact Details

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    Address:Hong Kong

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  • 4-HYDROXYPYRIDINE

  • Casno:

    626-64-2

    4-HYDROXYPYRIDINE

    Min.Order: 1 Gram

    FOB Price:  USD $ 0.0-0.0/Gram

    Company Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments

    AFINE CHEMICALS LIMITED is specialized in the fine chemicals and pharmaceuticals and we have enjoyed great popularity in world markets. Since 2005, we have been rapidly growing to

  •  Afine Chemicals Limited

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    Business Type:Lab/Research institutions

    Tel:+86-571-85134551

    Address:No. 206 Zhen Hua Road, Hangzhou 310030, Zhejiang, China

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Specification

The 4-Hydroxypyridine, with the CAS registry number of 626-64-2, is also known as 4-Pyridinol. It belongs to the product categories of Pyridine; Heterocyclic Compounds; Pyridines. Its EINECS registry number is 210-958-3. This chemical's molecular formula is C5H5NO and molecular weight is 95.1. What's more, its IUPAC name is 1H-Pyridin-4-one. In addition, it should be stored in dry, cool, airtight place. And it should avoid contact with oxidant, otherwise it would decompose.

Physical properties about 4-Hydroxypyridine are: (1)ACD/LogP: -0.99; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): -1; (4)ACD/LogD (pH 7.4): -0.99; (5)ACD/BCF (pH 5.5): 1; (6)ACD/BCF (pH 7.4): 1; (7)ACD/KOC (pH 5.5): 6.82; (8)ACD/KOC (pH 7.4): 6.86; (9)#H bond acceptors: 2; (10)#H bond donors: 1; (11)#Freely Rotating Bonds: 0; (12)Polar Surface Area: 20.31 Å2; (13)Index of Refraction: 1.513; (14)Molar Refractivity: 25.74 cm3; (15)Molar Volume: 85.5 cm3; (16)Polarizability: 10.2×10-24 cm3; (17)Surface Tension: 35.7 dyne/cm; (18)Density: 1.111 g/cm3; (19)Flash Point: 107.8 °C; (20)Enthalpy of Vaporization: 44.06 kJ/mol; (21)Boiling Point: 204.3 °C at 760 mmHg; (22)Melting Point: 150-151 °C(lit. ); (23)Vapour Pressure: 0.265 mmHg at 25 °C.

Preparation: this chemical is prepared by 4-Methoxy-pyridine. The reaction needs reagents Hexamethyldisilathiane and Sodium methoxide. The reaction time is 24 hours with reaction temperature of 180 °C. The yield is about 60 %.

Uses: (1)it can be used as intermediate to synthetic diuretic drug Torasemide or other drugs; (2)it is used to produce other chemicals. For example, it is used to produce 3-Nitro-pyridin-4-ol at heating. This reaction needs reagents HNO3, H2SO4 and SO3. Other condition of this reaction is reaction time of 1 hour. The yield is about 72 %.

When you are using this chemical, please be cautious about it as the following:
As a chemical, it is irritating to eyes, respiratory system and skin. In addition, this chemical may cause inflammation to the skin or other mucous membranes. During using it, wear suitable protective clothing, gloves and eye/face protection. In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.

You can still convert the following datas into molecular structure:
(1) SMILES: O=C\1\C=C/N/C=C/1
(2) InChI: InChI=1/C5H5NO/c7-5-1-3-6-4-2-5/h1-4H,(H,6,7)
(3) InChIKey: GCNTZFIIOFTKIY-UHFFFAOYAB