CAS No.63958-90-7,SERUM THYMIC FACTOR Suppliers

Products Categories

Pharmaceutical (133)
Organic Chemicals (25)
Others (11)
Plant Extract (2)
Reagent (1)

Basic Information

Molecular Structure:
CAS No.:	63958-90-7
Name:	SERUM THYMIC FACTOR
Article Data:	2

Formula:	C₃₃H₅₄N₁₂O₁₅
Molecular Weight:	858.863
Synonyms:	Thymulin(pig peptide moiety);Thymulin (swine peptide moiety) (9CI);L-Asparagine,N2-[N-[N-[N-[N2-[N-[N2-[N-(5-oxo-L-prolyl)-L-alanyl]-L-lysyl]-L-seryl]-L-glutaminyl]glycyl]glycyl]-L-seryl]-;Serum thymic factor;Serum thymic factor (porcine);Thymic serumfactor;Thymic serum factor (pig);
Density:	1.417 g/cm³
Boiling Point:	1658.9 °C at 760 mmHg
Flash Point:	957.1 °C
PSA:	451.86000
LogP:	-3.67790

Synthetic route

: 110523-43-8
pyroglutamyl-alanyl-Nε-benzyloxycarbonyllysyl-seryl-glutaminyl-glycyl-glycyl-seryl-asparagine 4-nitrobenzyl ester

: 63958-90-7
pyroglutamyl-alanyl-lysyl-seryl-glutaminyl-glycyl-glycyl-seryl-asparagine

Conditions

Conditions	Yield
With hydrogen; palladium In water; acetic acid for 12h; Ambient temperature;	84%

: Z-Pyr-Ala-Lys(Z)-Ser-Asn-Gly-Gly-Ser-Gln-ONb

: 63958-90-7
pyroglutamyl-alanyl-lysyl-seryl-glutaminyl-glycyl-glycyl-seryl-asparagine

Conditions

Conditions	Yield
With hydrogen; palladium on activated charcoal In acetic acid for 24h;	52%

: 16948-04-2
Nα-tert-butyloxycarbonyl-Nε-benzyloxycarbonyllysine dicyclohexylammonium salt

: 63958-90-7
pyroglutamyl-alanyl-lysyl-seryl-glutaminyl-glycyl-glycyl-seryl-asparagine

Conditions

Conditions	Yield
Multi-step reaction with 6 steps 1: 94 percent / HOBT, WSCl, NMM / tetrahydrofuran / 16 h / 4 °C 2: 1.) TFA, anisole 2.) HOBT, WSCl, NMM / 1.) room temperature, 20 min 2.) DMF, 4 deg C, overnight 3: 1.) TFA, anisole 2.) NMM, HOBT, WSCl / 1.) room temperature, 20 min 2.) DMF, 0 deg C, overnight, 4 deg C 4: 94 percent / hydrazine hydrate / dimethylformamide; methanol / 48 h / Ambient temperature 6: 52 percent / H2 / 10 percent Pd/C / aq. acetic acid / 24 h View Scheme

Yield

Multi-step reaction with 6 steps
1: 94 percent / HOBT, WSCl, NMM / tetrahydrofuran / 16 h / 4 °C
2: 1.) TFA, anisole 2.) HOBT, WSCl, NMM / 1.) room temperature, 20 min 2.) DMF, 4 deg C, overnight
3: 1.) TFA, anisole 2.) NMM, HOBT, WSCl / 1.) room temperature, 20 min 2.) DMF, 0 deg C, overnight, 4 deg C
4: 94 percent / hydrazine hydrate / dimethylformamide; methanol / 48 h / Ambient temperature
6: 52 percent / H2 / 10 percent Pd/C / aq. acetic acid / 24 h
View Scheme

: 84983-67-5
tert.-butyloxycarbonylalanyl-Nε-benzyloxycarbonyllysyl-serine methyl ester

: 63958-90-7
pyroglutamyl-alanyl-lysyl-seryl-glutaminyl-glycyl-glycyl-seryl-asparagine

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1: 1.) TFA, anisole 2.) NMM, HOBT, WSCl / 1.) room temperature, 20 min 2.) DMF, 0 deg C, overnight, 4 deg C 2: 94 percent / hydrazine hydrate / dimethylformamide; methanol / 48 h / Ambient temperature 4: 52 percent / H2 / 10 percent Pd/C / aq. acetic acid / 24 h View Scheme
Multi-step reaction with 5 steps 1: 88 percent / NaOH / methanol; H2O / 0.5 h / Ambient temperature 2: 1) triethylamine, 1-hydroxybenztriazole, N,N'-dicyclohexylcarbodiimide / 1) dimethylformamide, -10 deg C, 10 min, 2) 0 deg C, 2 h, room temperature, 8 h 3: 93 percent / hydrogen chloride / acetic acid; H2O / 0.75 h / Ambient temperature 4: 1) 1-hydroxybenztriazole, N,N'-dicyclohexylcarbodiimide 2) N-ethylpiperidine / 1) dimethylformamide, -10 deg C, 10 min, 2) 0 deg C, 2 h, then room temperature, 8 h 5: 84 percent / H2 / Pd-black / acetic acid; H2O / 12 h / Ambient temperature View Scheme

Yield

Multi-step reaction with 4 steps
1: 1.) TFA, anisole 2.) NMM, HOBT, WSCl / 1.) room temperature, 20 min 2.) DMF, 0 deg C, overnight, 4 deg C
2: 94 percent / hydrazine hydrate / dimethylformamide; methanol / 48 h / Ambient temperature
4: 52 percent / H2 / 10 percent Pd/C / aq. acetic acid / 24 h
View Scheme

Multi-step reaction with 5 steps
1: 88 percent / NaOH / methanol; H2O / 0.5 h / Ambient temperature
2: 1) triethylamine, 1-hydroxybenztriazole, N,N'-dicyclohexylcarbodiimide / 1) dimethylformamide, -10 deg C, 10 min, 2) 0 deg C, 2 h, room temperature, 8 h
3: 93 percent / hydrogen chloride / acetic acid; H2O / 0.75 h / Ambient temperature
4: 1) 1-hydroxybenztriazole, N,N'-dicyclohexylcarbodiimide 2) N-ethylpiperidine / 1) dimethylformamide, -10 deg C, 10 min, 2) 0 deg C, 2 h, then room temperature, 8 h
5: 84 percent / H2 / Pd-black / acetic acid; H2O / 12 h / Ambient temperature
View Scheme

: Boc-Ser-Gln-ONb

: 63958-90-7
pyroglutamyl-alanyl-lysyl-seryl-glutaminyl-glycyl-glycyl-seryl-asparagine

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1: 1.) TFA, anisole 2.) HOBT, WSCl, NMM / 1.) room temperature, 20 min 2.) DMF, 4 deg C, overnight 2: 1.) TFA, anisole 2.) NMM / 1.) room temperature, 20 min 2.) DMF, room temperature, 18 h. 4: 52 percent / H2 / 10 percent Pd/C / aq. acetic acid / 24 h View Scheme

: Boc-Gly-Gly-Ser-Gln-ONb

: 63958-90-7
pyroglutamyl-alanyl-lysyl-seryl-glutaminyl-glycyl-glycyl-seryl-asparagine

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: 1.) TFA, anisole 2.) NMM / 1.) room temperature, 20 min 2.) DMF, room temperature, 18 h. 3: 52 percent / H2 / 10 percent Pd/C / aq. acetic acid / 24 h View Scheme

: 84983-68-6
Z-Pyr-Ala-Lys(Z)-Ser-OMe

: 63958-90-7
pyroglutamyl-alanyl-lysyl-seryl-glutaminyl-glycyl-glycyl-seryl-asparagine

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: 94 percent / hydrazine hydrate / dimethylformamide; methanol / 48 h / Ambient temperature 3: 52 percent / H2 / 10 percent Pd/C / aq. acetic acid / 24 h View Scheme

: 84983-69-7
Z-Pyr-Ala-Lys(Z)-Ser-NHNH2

: 63958-90-7
pyroglutamyl-alanyl-lysyl-seryl-glutaminyl-glycyl-glycyl-seryl-asparagine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 2: 52 percent / H2 / 10 percent Pd/C / aq. acetic acid / 24 h View Scheme

: Boc-Asn-Gly-Gly-Ser-Gln-ONb

: 63958-90-7
pyroglutamyl-alanyl-lysyl-seryl-glutaminyl-glycyl-glycyl-seryl-asparagine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 2: 52 percent / H2 / 10 percent Pd/C / aq. acetic acid / 24 h View Scheme

: 84983-66-4
Boc-Lys(Z)-Ser-OMe

: 63958-90-7
pyroglutamyl-alanyl-lysyl-seryl-glutaminyl-glycyl-glycyl-seryl-asparagine

Conditions

Conditions	Yield
Multi-step reaction with 5 steps 1: 1.) TFA, anisole 2.) HOBT, WSCl, NMM / 1.) room temperature, 20 min 2.) DMF, 4 deg C, overnight 2: 1.) TFA, anisole 2.) NMM, HOBT, WSCl / 1.) room temperature, 20 min 2.) DMF, 0 deg C, overnight, 4 deg C 3: 94 percent / hydrazine hydrate / dimethylformamide; methanol / 48 h / Ambient temperature 5: 52 percent / H2 / 10 percent Pd/C / aq. acetic acid / 24 h View Scheme

Yield

Multi-step reaction with 5 steps
1: 1.) TFA, anisole 2.) HOBT, WSCl, NMM / 1.) room temperature, 20 min 2.) DMF, 4 deg C, overnight
2: 1.) TFA, anisole 2.) NMM, HOBT, WSCl / 1.) room temperature, 20 min 2.) DMF, 0 deg C, overnight, 4 deg C
3: 94 percent / hydrazine hydrate / dimethylformamide; methanol / 48 h / Ambient temperature
5: 52 percent / H2 / 10 percent Pd/C / aq. acetic acid / 24 h
View Scheme

Total:84 Page 1 of 3 1 2 3 Next>>

Post a RFQ

Cas No.:

Product Name:

Quantity:

Email:

Company name:

Valid Period:

Detailed Requirements:

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

What can I do for you?
Get Best Price

Get Best Price for 63958-90-7

Specification

The Thymulin, with the CAS registry number 63958-90-7, is also known as Serum thymic factor. It belongs to the product category of Peptide. Thymulin is a nonapeptide produced by two distinct epithelial populations in the thymus. This chemical's molecular formula is C₃₃H₅₄N₁₂O₁₅ and molecular weight is 858.85. What's more, its IUPAC name is (2S)-4-Amino-2-[[(2S)-2-[[2-[[2-[[(2S)-5-amino-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-5-oxopyrrolidine-2-carbonyl]amino]propanoyl]amino]hexanoyl]amino]-3-hydroxypropanoyl]amino]-5-oxopentanoyl]amino]acetyl]amino]acetyl]amino]-3-hydroxypropanoyl]amino]-4-oxobutanoic acid. In addition, it must be stored in airtight containers at -20 °C and placed in a dry, cool place. Meanwhile, it should be kept away from oxidant, strong acid, strong alkali.

Physical properties about Thymulin are: (1)ACD/LogP: -7.44; (2)# of Rule of 5 Violations: 3; (3)ACD/LogD (pH 5.5): -9.94; (4)ACD/LogD (pH 7.4): -9.93; (5)ACD/BCF (pH 5.5): 1; (6)ACD/BCF (pH 7.4): 1; (7)ACD/KOC (pH 5.5): 1; (8)ACD/KOC (pH 7.4): 1; (9)#H bond acceptors: 27; (10)#H bond donors: 18; (11)#Freely Rotating Bonds: 31; (12)Polar Surface Area: 271.41 Å²; (13)Index of Refraction: 1.575; (14)Molar Refractivity: 200.23 cm³; (15)Molar Volume: 605.7 cm³; (16)Polarizability: 79.37×10^-24 cm³; (17)Surface Tension: 72.1 dyne/cm; (18)Density: 1.417 g/cm³; (19)Flash Point: 957.1 °C; (20)Enthalpy of Vaporization: 293.02 kJ/mol; (21)Boiling Point: 1658.9 °C at 760 mmHg; (22)Vapour Pressure: 0 mmHg at 25 °C.

Uses of Thymulin: it can be used as drugs for primary and secondary immunodeficiency disease, immune function disorder disease, tumor adjunctive treatment, aplastic anemia, acute or chronic viral hepatitis, lupus erythematosus, rheumatoid arthritis, allergic asthma and so on. Besides, Thymulin can be used as an effector on proinflammatory mediators/cytokines. And researchers hope to develop drugs thwarting inflammatory processes associated with neurodegenerative diseases and even rheumatism with the help of thymulin analogs.

You can still convert the following datas into molecular structure:
(1) SMILES: O=C(N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)NCC(=O)NCC(=O)N[C@H](C(=O)N[C@H](C(=O)O)CC(=O)N)CO)CCC(=O)N)CO)CCCCN)C)[C@H]1NC(=O)CC1
(2) InChI: InChI=1/C33H54N12O15/c1-15(39-29(55)18-6-8-24(50)40-18)27(53)42-16(4-2-3-9-34)30(56)45-21(14-47)32(58)43-17(5-7-22(35)48)28(54)38-11-25(51)37-12-26(52)41-20(13-46)31(57)44-19(33(59)60)10-23(36)49/h15-21,46-47H,2-14,34H2,1H3,(H2,35,48)(H2,36,49)(H,37,51)(H,38,54)(H,39,55)(H,40,50)(H,41,52)(H,42,53)(H,43,58)(H,44,57)(H,45,56)(H,59,60)/t15-,16-,17-,18-,19-,20-,21-/m0/s1
(3) InChIKey: LIFNDDBLJFPEAN-BPSSIEEOBB