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64-31-3

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Basic Information
CAS No.: 64-31-3
Name: MORPHINE SULFATE NARCOTIC ANALGESIC
Article Data: 2
Molecular Structure:
Molecular Structure of 64-31-3 (MORPHINE SULFATE NARCOTIC ANALGESIC)
Formula: C34H38N2O6•H2O4S
Molecular Weight: 383.422
Synonyms: Morphinan-3,6-diol, 7, 8-didehydro-4,5-epoxy-17-methyl- (5.alpha.,6.alpha.)-, sulfate (2:1) (salt);NIH 0001;Morphinan-3,6-alpha-diol, 7,8-didehydro-4, 5-alpha-epoxy-17-methyl-, sulfate;Duramorph;Moscontin;(-)(5.alpha.,6.alpha.)-7,8-Didehydro-4,5-epoxy-17-methylmorphinan-3,6-diol;1095-53-0;Morphinan-3,6alpha-diol, 7,8-didehydro-4,5alpha-epoxy-17-methyl-, sulfate (2:1) (salt);Morphinan-3,6-diol, 7,8-didehydro-4,5-epoxy-17-methyl- (5alpha,6alpha)-, sulfate (2:1) (salt);l-Morphine sulfate;Infumorph;Avinza;Morphine sulphate;178935-96-1;Morphinan-3,6.alpha.-diol, 7,8-didehydro-4, 5.alpha.-epoxy-17-methyl-, sulfate (2:1) (salt);Morphinan-3,6.alpha.-diol, 7,8-didehydro-4, 5.alpha.-epoxy-17-methyl-, sulfate;57-27-2;Morphinan-3,6-diol, 7,8-didehydro-4,5-epoxy-17-methyl- (5..alpha.,6.alpha.)-;MST;Morphine, hemisulfate;Morphine sulfate anhydrous;Skenan;Kapanol;(-)Morphine sulfate;NIH 10753;MST-1 Continus;
EINECS: 200-582-8
Melting Point: 250 °C
Boiling Point: 476.2°C at 760 mmHg
Flash Point: 241.8°C
Hazard Symbols: F,T
Risk Codes: 11-23/24/25-39/23/24/25
Safety: Poison by subcutaneous, intravenous, intraperitoneal, and intramuscular routes. Moderately toxic by ingestion and parenteral routes. An experimental teratogen. Experimental reproductive effects. Mutation data reported. Used as a narcotic. Abuse leads to habituation or addiction. When heated to decomposition it emits very toxic fumes of NOx and SOx. See also (−)-MORPHINE and SULFATES.
PSA: 135.91000
LogP: 1.56400
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Specification

The Morphine sulfate, with the CAS registry number 64-31-3,is also known as Astramorph. It belongs to the product categories of Organic matters. This chemical's molecular formula is C34H40N2O10S and molecular weight is 668.75.Its EINECS number is 200-582-8.What's more,Its systematic name is Morphine sulphate.The principal alkaloid in opium and the prototype opiate analgesic and narcotic. Morphine has widespread effects in the central nervous system and on smooth muscle. Most morphine produced for pharmaceutical use around the world is actually converted into codeine as the concentration of the latter in both raw opium and poppy straw is much lower than that of morphine.Whilst strains of poppies have been engineered to produce much higher yields of the other useful opioid pharmaceutical precursors thebaine and oripavine, no known strain of P. somniferum will produce more codeine than morphine under most or all possible conditions.

Physical properties about  Morphine sulfate are:
(1)ACD/LogP:  0.43; (2)# of Rule of 5 Violations:  0; (3)#H bond acceptors:  4; (4)#H bond donors:  2; (5)#Freely Rotating Bonds:  2; (6)Flash Point:  241.8 °C; (7)Enthalpy of Vaporization:  77.95 kJ/mol ; (8)Boiling Point:  476.2 °C at 760 mmHg; (9)Vapour Pressure:  7.06E-10 mmHg at 25°C.

You can still convert the following datas into molecular structure:
(1)SMILES:[O-]S([O-])(=O)=O.O[C@H]1\C=C/[C@H]5[C@@H]4[NH+](C)CC[C@@]52c3c(O[C@@H]12)c(O)ccc3C4.O[C@H]4\C=C/[C@H]2[C@H]3Cc5c1c(O[C@@H]4[C@]12CC[NH+]3C)c(O)cc5;
(2)Std. InChI:InChI=1S/2C17H19NO3.H2O4S/c2*1-18-7-6-17-10-3-5-13(20)16(17)21-15-12(19)4-2-9(14(15)17)8-11(10)18;1-5(2,3)4/h2*2-5,10-11,13,16,19-20H,6-8H2,1H3;(H2,1,2,3,4)/t2*10-,11+,13-,16-,17-;/m00./s1;
(3)Std. InChIKey:USAHOPJHPJHUNS-IFCNUISUSA-N.

Safety Information of Morphine sulfate:
The Morphine sulfate is danger of very serious irreversible effects through inhalation, in contact with skin and if swallowed .And it is highly flammable.So it need Keep away from sources of ignition. When you use it ,you should wear suitable protective clothing and gloves.In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.).After use ,keep container tightly closed.

The toxicity data of  Morphine sulfate are as follows:

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
chicken LDLo intravenous 125mg/kg (125mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: ATAXIA

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Archives Internationales de Pharmacodynamie et de Therapie. Vol. 79, Pg. 282, 1949.
dog LD50 intravenous 316mg/kg (316mg/kg) BEHAVIORAL: SLEEP

BEHAVIORAL: ANALGESIA
Archives Internationales de Pharmacodynamie et de Therapie. Vol. 149, Pg. 571, 1964.
duck LD50 intravenous 213mg/kg (213mg/kg) BEHAVIORAL: ATAXIA

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)
Archives Internationales de Pharmacodynamie et de Therapie. Vol. 79, Pg. 282, 1949.
frog LD50 parenteral 678mg/kg (678mg/kg) BEHAVIORAL: ATAXIA

BEHAVIORAL: CHANGES IN PSYCHOPHYSIOLOGICAL TESTS
Archives Internationales de Pharmacodynamie et de Therapie. Vol. 79, Pg. 282, 1949.
frog LD50 subcutaneous 677mg/kg (677mg/kg)   Annals of the New York Academy of Sciences. Vol. 51, Pg. 83, 1948.
guinea pig LD50 subcutaneous 391mg/kg (391mg/kg)   Annals of the New York Academy of Sciences. Vol. 51, Pg. 83, 1948.
guinea pig LDLo intramuscular 400mg/kg (400mg/kg)   JAMA, Journal of the American Medical Association. Vol. 63, Pg. 469, 1914.
guinea pig LDLo oral 1gm/kg (1000mg/kg)   JAMA, Journal of the American Medical Association. Vol. 63, Pg. 469, 1914.
hamster LD50 subcutaneous 1250mg/kg (1250mg/kg)   Proceedings of the Society for Experimental Biology and Medicine. Vol. 54, Pg. 339, 1943.
man TDLo oral 12mg/kg/4W-I (12mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Drug Intelligence and Clinical Pharmacy. Vol. 22, Pg. 397, 1988.
mouse LD50 intracrebral 5100ug/kg (5.1mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Journal of Pharmacology and Experimental Therapeutics. Vol. 140, Pg. 155, 1963.
mouse LD50 intramuscular 334mg/kg (334mg/kg) GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"

LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)
Archives Internationales de Pharmacodynamie et de Therapie. Vol. 190, Pg. 124, 1971.
mouse LD50 intraperitoneal 275mg/kg (275mg/kg) BEHAVIORAL: ANALGESIA Journal of Medicinal Chemistry. Vol. 10, Pg. 627, 1967.
mouse LD50 intravenous 156mg/kg (156mg/kg) BEHAVIORAL: REGIDITY

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Journal of Pharmacology and Experimental Therapeutics. Vol. 157, Pg. 185, 1967.
mouse LD50 oral 600mg/kg (600mg/kg) BEHAVIORAL: ANALGESIA Journal of Pharmacology and Experimental Therapeutics. Vol. 133, Pg. 400, 1961.
mouse LD50 subcutaneous 180mg/kg (180mg/kg) BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Australian Veterinary Journal. Vol. 49, Pg. 525, 1973.
pigeon LD50 intravenous 321mg/kg (321mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: ATAXIA
Archives Internationales de Pharmacodynamie et de Therapie. Vol. 79, Pg. 282, 1949.
rat LD50 intramuscular 78mg/kg (78mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)

GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"
Archives Internationales de Pharmacodynamie et de Therapie. Vol. 190, Pg. 124, 1971.
rat LD50 intraperitoneal 235mg/kg (235mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Acta Pharmacologica et Toxicologica. Vol. 22, Pg. 241, 1965.
rat LD50 intravenous 70mg/kg (70mg/kg)   Toxicology and Applied Pharmacology. Vol. 17, Pg. 250, 1970.
rat LD50 oral 461mg/kg (461mg/kg)   British Journal of Pharmacology and Chemotherapy. Vol. 30, Pg. 11, 1967.
rat LD50 subcutaneous 108mg/kg (108mg/kg) ENDOCRINE: OTHER CHANGES British Journal of Pharmacology and Chemotherapy. Vol. 10, Pg. 260, 1955.
women TDLo oral 8mg/kg (8mg/kg) BEHAVIORAL: ANALGESIA Lancet. Vol. 1, Pg. 573, 1987.