CAS No.65-29-2,Gallamine triethiodide Suppliers

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Basic Information

Molecular Structure:
CAS No.:	65-29-2
Name:	Gallamine triethiodide

Formula:	C₃₀H₆₀I₃N₃O₃
Molecular Weight:	891.538
Synonyms:	Ammonium,[v-phenenyltris(oxyethylene)]tris[triethyl-, triiodide (8CI);Ethanaminium,2,2',2''-[1,2,3-benzenetriyltris(oxy)]tris[N,N,N-triethyl-, triiodide (9CI);[v-Phenenyltris(oxyethylene)]tris[triethylammonium iodide] (6CI,7CI);1,2,3-Tri(b-diethylaminoethoxy)benzenetriethiodide;1,2,3-Tris(2-diethylaminoethoxy)benzene triethiodide;1,2,3-Tris(2-diethylaminoethoxy)benzene tris(ethyliodide);1,2,3-Tris(2-triethylammonium ethoxy)benzene triiodide;1,2,3-Tris(diethylaminoethoxy)benzene triethiodide;3697 RP;Benzcurine iodide;F 2559;Flacedil;Flaxedil;Flaxedil iodide;Fourneau 2559;Gallaflex;Gallamintriethiodide;Gallamine iodide;Gallamine triethiodide;Gallaminetriiodoethylate;HL 8583;Miowas G;Parexyl;Pyrogallol1,2,3-(diethylaminoethyl ether) tris(ethyliodide);Pyrolaxon;RP 3697;Relaxan;Remyolan;Retensin;Sincurarine;Syncurarine;Tri(diethylaminoethoxy)-1,2,3-benzene triiodoethylate;Tri(b-diethylaminoethoxy)-1,2,3-benzenetri-iodoethylate;
EINECS:	200-605-1
Density:	0.983g/cm³
Melting Point:	235 ºC (dec.)
Boiling Point:	502.6°C at 760 mmHg
Flash Point:	125.9°C
Solubility:	100 mg/mL in water
Appearance:	White or milky white crystalline powder
Hazard Symbols:
Risk Codes:	R22;R36/37/38
Safety:	Poison by ingestion, subcutaneous, intravenous, parenteral, intraduodenal, intraperitoneal, and intramuscular routes. When heated to decomposition it emits very toxic fumes of NH₃, NO_x, and I⁻. See also IODIDES.
PSA:	27.69000
LogP:	-3.53550

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Specification

With CAS register number 65-29-2, Gallamine triethiodide is also can be called Tri(beta-diethylaminoethoxy)-1,2,3-benzene triiodoethylate ; Pyrogallol 1,2,3-(diethylaminoethyl ether) tris(ethyl iodide) ; 1,2,3-Tris(2-diethylaminoethoxy)benzene tris(ethyl iodide) and 2-[2,6-Bis(2-triethylazaniumylethoxy)phenoxy]ethyl-triethylazanium triiodide . Gallamine triethiodide ,which was developed by Daniel Bovet in 1947, is storage at 2-8 °C, soluble in water with 100 mg/mL. And it belongs to product categories such as Organics; Cholinergics; Antagonists and so on, it is white or milky white crystalline powder.

Used as a synthetic nondepolarizing blocking drug, the actions of gallamine triethiodide are similar to those of tubocurarine, but this agent blocks the cardiac vagus and may cause sinus tachycardia and, occasionally, hypertension and increased cardiac output.It is also commonly used to stabilize muscle contractions during surgical procedures. Besides, Gallamine triethiodide is a non-depolarising muscle relaxant, which acts by combining with the cholinergic receptor sites in muscle and competitively blocking the transmitter action of acetylcholine. In addition, first make focus of gallic acid, under the action of Sodium acetate , into the salt, and then with Diethylamino ethyl ethane and Iodine ethane to get Gallamine triethiodide.

The Gallamine triethiodide has a parasympatholytic effect on the cardiac vagus nerve which causes tachycardia and occasionally hypertension and very high doses cause histamine release. It should be used cautiously in patients at risk from increased heart rate but may be preferred for patients with bradycardia. And Gallamine triethiodide is poison by ingestion, subcutaneous, intravenous, parenteral, intraduodenal, intraperitoneal, and intramuscular routes. When heated to decomposition it emits very toxic fumes of NH₃, NO_x, and I^-. Furthermore, it is harmful if swallowed and irritating to eyes, respiratory system and skin. So you should wear suitable protective clothing in case of contact with eyes, rinse immediately with plenty of water and seek medical advice. The toxicity of Gallamine triethiodide as follows:

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
chicken	LD50	intravenous	600ug/kg (0.6mg/kg)		Archives Internationales de Pharmacodynamie et de Therapie. Vol. 122, Pg. 152, 1959.
dog	LD50	intravenous	800ug/kg (0.8mg/kg)		Archives Internationales de Pharmacodynamie et de Therapie. Vol. 80, Pg. 172, 1949.
mouse	LD50	intraperitoneal	10mg/kg (10mg/kg)	PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE) BEHAVIORAL: EXCITEMENT LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION	Archives Internationales de Pharmacodynamie et de Therapie. Vol. 184, Pg. 75, 1970.
mouse	LD50	intravenous	1800ug/kg (1.8mg/kg)		U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. Vol. NX#01979,
mouse	LD50	oral	425mg/kg (425mg/kg)		Archives Internationales de Pharmacodynamie et de Therapie. Vol. 80, Pg. 172, 1949.
mouse	LD50	parenteral	1700ug/kg (1.7mg/kg)	LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES	Annales Pharmaceutiques Francaises. Vol. 7, Pg. 368, 1949.
mouse	LD50	subcutaneous	16400ug/kg (16.4mg/kg)	BEHAVIORAL: MUSCLE WEAKNESS LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES	Oyo Yakuri. Pharmacometrics. Vol. 9, Pg. 117, 1975.
rabbit	LD50	intravenous	440ug/kg (0.44mg/kg)	SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE BEHAVIORAL: REGIDITY BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)	International Journal of Neuropharmacology. Vol. 5, Pg. 305, 1966.
rabbit	LD50	oral	100mg/kg (100mg/kg)		Archives Internationales de Pharmacodynamie et de Therapie. Vol. 80, Pg. 172, 1949.
rabbit	LDLo	intramuscular	2mg/kg (2mg/kg)		Archives Internationales de Pharmacodynamie et de Therapie. Vol. 80, Pg. 172, 1949.
rabbit	LDLo	subcutaneous	2mg/kg (2mg/kg)		Archives Internationales de Pharmacodynamie et de Therapie. Vol. 80, Pg. 172, 1949.
rat	LD50	intraduodenal	380mg/kg (380mg/kg)		Archives Internationales de Pharmacodynamie et de Therapie. Vol. 180, Pg. 155, 1969.
rat	LD50	intraperitoneal	23200ug/kg (23.2mg/kg)		Drugs in Japan Vol. 6, Pg. 178, 1982.
rat	LD50	intravenous	5100ug/kg (5.1mg/kg)		Drugs in Japan Vol. 6, Pg. 178, 1982.
rat	LD50	oral	> 1gm/kg (1000mg/kg)		Drugs in Japan Vol. 6, Pg. 178, 1982.
rat	LD50	subcutaneous	28500ug/kg (28.5mg/kg)		Drugs in Japan Vol. 6, Pg. 178, 1982.