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| CAS No.: | 66215-27-8 |
|---|---|
| Name: | Cyromazine |
| Molecular Structure: | |
|
|
|
| Formula: | C6H10N6 |
| Molecular Weight: | 166.186 |
| Synonyms: | 1,3,5-Triazine-2,4,6-triamine,N-cyclopropyl- (9CI);2,4-Diamino-6-(cyclopropylamino)-s-triazine;2-Cyclopropylamino-4,6-diamino-s-triazine;CGA 72662;Citation;Cyclopropylmelamine; |
| EINECS: | 266-257-8 |
| Density: | 1.622 g/cm3 |
| Melting Point: | 223-227 °C(lit.) |
| Boiling Point: | 480.7 °C at 760 mmHg |
| Flash Point: | 244.5 °C |
| Solubility: | 13 g l-1 (pH 7.1,25 °C) |
| Appearance: | Colorless crystal |
| Hazard Symbols: |
 Xi
|
| Risk Codes: | 36/37/38 |
| Safety: | 26-36 |
| PSA: | 102.74000 |
| LogP: | 0.84570 |
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- 894852-01-87-BROMO-2,2-DIMETHYL-2H-PYRIDO[3,2-B][1,4]OXAZIN-3(4H)-ONE
| Conditions | Yield |
|---|---|
| With sodium hydroxide at 70 - 85℃; for 6h; pH=9.5; pH-value; Temperature; | 96.37% |
| With potassium carbonate In water at 95 - 100℃; for 4h; pH=7.5 - 8.5; Temperature; Reagent/catalyst; | 90.1% |
| With sodium hydroxide at -10 - 10℃; for 10h; Temperature; | 24.47 g |
- 32889-45-5
2,4-dichloro-6-cyclopropylamino-1,3,5-triazine
- 66215-27-8
cyromazine
| Conditions | Yield |
|---|---|
| With ammonia In water; toluene at 120℃; under 4500.45 Torr; for 10h; | 93.5% |
| Conditions | Yield |
|---|---|
| With ammonia | |
| With ammonia |
- 35516-73-5
6-chloro-N-cyclopropyl-[1,3,5]triazine-2,4-diamine
- 66215-27-8
cyromazine
| Conditions | Yield |
|---|---|
| With ammonia In 1,4-dioxane; water |
- 66215-27-8
cyromazine
- 543-27-1
isobutyl chloroformate
| Conditions | Yield |
|---|---|
| With pyridine; dmap In chloroform |
| Conditions | Yield |
|---|---|
| In pyridine |
- 38870-89-2
Methoxyacetyl chloride
- 66215-27-8
cyromazine
| Conditions | Yield |
|---|---|
| In pyridine |
- 66215-27-8
cyromazine
| Conditions | Yield |
|---|---|
| With acetic anhydride; triethylamine In tetrahydrofuran; diethyl ether |
- 19500-95-9
Methoxyacetic anhydride
- 66215-27-8
cyromazine
- 99135-52-1
2-cyclopropylamino-4-methoxyacetylamino-6-amino-1,3,5-triazine
| Conditions | Yield |
|---|---|
| With triethylamine In tetrahydrofuran; diethyl ether |
- 40244-90-4
Chlorodiisopropylphosphane
- 66215-27-8
cyromazine
| Conditions | Yield |
|---|---|
| With triethylamine In tetrahydrofuran at 60℃; Inert atmosphere; Sealed tube; |
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Chemistry
Molecular structure of Cyromazine (CAS NO.66215-27-8) is:
Product Name: Cyromazine
CAS Registry Number: 66215-27-8
IUPAC Name: 2-N-cyclopropyl-1,3,5-triazine-2,4,6-triamine
Molecular Weight: 166.1838 [g/mol]
Molecular Formula: C6H10N6
XLogP3: -0.2
H-Bond Donor: 3
H-Bond Acceptor: 6
EINECS: 266-257-8
Melting Point: 223-227 °C(lit.)
Surface Tension: 132.7 dyne/cm
Density: 1.622 g/cm3
Flash Point: 244.5 °C
Enthalpy of Vaporization: 74.52 kJ/mol
Boiling Point: 480.7 °C at 760 mmHg
Vapour Pressure: 2.13E-09 mmHg at 25°C
Product Categories: Fine Chemical & Intermediates;Active Pharmaceutical Ingredients;Insecticide
Uses
In veterinary medicine, Cyromazine (CAS NO.66215-27-8) is used as a ectoparasiticide. Also it can be used as an insecticide and an acaricide.
Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| domestic animals - goat/sheep | LDLo | oral | 500mg/kg (500mg/kg) | PERIPHERAL NERVE AND SENSATION: FASCICULATIONS BEHAVIORAL: ATAXIA | National Technical Information Service. Vol. OTS0538005, |
| duck | LD50 | oral | > 6gm/kg (6000mg/kg) | Farm Chemicals Handbook. Vol. -, Pg. C91, 1991. | |
| quail | LD50 | oral | 1785mg/kg (1785mg/kg) | Pesticide Manual. Vol. 9, Pg. 217, 1991. | |
| rat | LC50 | inhalation | > 2720mg/m3/4H (2720mg/m3) | Pesticide Manual. Vol. 9, Pg. 217, 1991. | |
| rat | LD50 | oral | 3387mg/kg (3387mg/kg) | Pesticide Manual. Vol. 9, Pg. 217, 1991. | |
| rat | LD50 | skin | > 3100mg/kg (3100mg/kg) | Pesticide Manual. Vol. 9, Pg. 217, 1991. |
Safety Profile
The Food Safety and Inspection Service (FSIS) of the United States Department of Agriculture (USDA) provides a test method for analyzing cyromazine and Melamine in animal tissues in its Chemistry Laboratory Guidebook which "contains test methods used by FSIS Laboratories to support the Agency's inspection program, ensuring that meat, poultry, and egg products are safe, wholesome and accurately labeled." In 1999, in a proposed rule published in the Federal Register regarding cyromazine residue, the United States Environmental Protection Agency (EPA) proposed "remov[ing] Melamine, a metabolite of cyromazine from the tolerance expression since it is no longer considered a residue of concern."
Hazard Codes: 
Xi
Risk Statements: 36/37/38
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements: 26-36
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36:Wear suitable protective clothing.
WGK Germany: 2
RTECS: XZ1056500
Specification
Cyromazine , its cas register number is 66215-27-8. It also can be called N-cyclopropyl-1,3,5-triazine-2,4,6-triamine ; 2-Cyclopropylamino-4,6-diamino-s-triazine ; Diamino-6-(cyclopropylamino)-s-triazine ; Cyclopropyl-1,3,5-triazine-2,4,6-triamine ; Cyclopropylmelamine ; Larvadex ; OMS-2014 ; Trigard .It is a crystals.It works by affecting the nervous system of the immature larval stages of certain insects.