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6870-67-3

Basic Information
CAS No.: 6870-67-3
Name: Jacobine.
Molecular Structure:
Molecular Structure of 6870-67-3 (Jacobine.)
Formula: C18H25 N O6
Molecular Weight: 351.4
Synonyms: Jacobine(6CI,7CI,8CI); Senecionan-11,16-dione, 15,20-epoxy-15,20-dihydro-12-hydroxy-,(15a,20S)-; NSC 89936;Spiro[[1,6]dioxacyclododecino[2,3,4-gh]pyrrolizine-3(2H),2'-oxirane]-2,7(4H)-dione,5,6,9,11,13,14,14a,14b-octahydro-6-hydroxy-3',5,6-trimethyl-,[3S-[3R*(R*),5S*,6S*,14aS*,14bS*]]-
Density: 1.33g/cm3
Melting Point: 228°C
Boiling Point: 574.1°C at 760 mmHg
Flash Point: 301°C
Safety: Poison by intravenous route. Questionable carcinogen. Mutation data reported. When heated to decomposition it emits toxic fumes of NOx.
PSA: 88.60000
LogP: 0.34190
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Chemistry

Jacobine(6870-67-3)'s molecular formula is C18H25NO6  and its formula weight is 351.44.
Jacobine(6870-67-3)'s chemical synonyms are Jacobine(6870-67-3);(15R,20S)-15,20-Dihydro-15,20-epoxy-12-hydroxysenecionan-11,16-dione;(20S)-15α,20-Epoxy-15,20-dihydro-12-hydroxysenecionan-11,16-dione;NSC-89936. 
The molecular structure of jacobine(6870-67-3):

Toxicity Data With Reference

1.   

sln-dmg-par 20 µmol/L

   ZEVBA5    Zeitschrift fuer Verebungslehre. 91 (1960),74.
2.   

dns-rat:lvr 1 µmol/L

   CNREA8    Cancer Research. 45 (1985),3125.
3.   

ivn-mus LD50:77 mg/kg

   JPETAB    Journal of Pharmacology and Experimental Therapeutics. 75 (1942),69.

Consensus Reports

IARC Cancer Review: Group 3 IMEMDT    IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 7 (1987),p. 56.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) ; Animal Inadequate Evidence IMEMDT    IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 10 (1976),p. 275.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) . EPA Genetic Toxicology Program.

Safety Profile

Poison by intravenous route. Questionable carcinogen. Mutation data reported. When heated to decomposition it emits toxic fumes of NOx.