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| CAS No.: | 69-05-6 |
|---|---|
| Name: | QUINACRINE DIHYDROCHLORIDE |
| Molecular Structure: | |
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| Formula: | C23H30 Cl N3 O . 2 Cl H |
| Molecular Weight: | 472.886 |
| Synonyms: | 1,4-Pentanediamine,N4-(6-chloro-2-methoxy-9-acridinyl)-N1,N1-diethyl-, dihydrochloride (9CI);Acridine, 6-chloro-9-[[4-(diethylamino)-1-methylbutyl]amino]-2-methoxy-,dihydrochloride (8CI); 2-Chloro-5-(w-diethylamino-a-methylbutylamino)-7-methoxyacridine dihydrochloride;2-Methoxy-6-chloro-9-(4-diethylamino-1-methylbutylamino)acridinedihydrochloride;3-Chloro-7-methoxy-9-(1-methyl-4-diethylaminobutylamino)acridinedihydrochloride;3-Chloro-9-(4'-diethylamino-1'-methylbutylamino)-7-methoxyacridinedihydrochloride; 6-Chloro-9-[[4-(diethylamino)-1-methylbutyl]amino]-2-methoxyacridinedihydrochloride; 866RP; Acrichin dihydrochloride; Atabrine hydrochloride;Atebrin; Atebrine; Atebrine hydrochloride; Chemiochin; Chinacrin hydrochloride;Crinodora; Erion; Malaricida; Mecryl; Mepacrine dihydrochloride; Mepacrine hydrochloride;Methoquine; Metochin; Metoquin; Metoquine; NSC 14229; Palacrin; Palusan;Pentilen; Quinacrine dihydrochloride; Quinacrine hydrochloride; SN 390 |
| EINECS: | 200-700-8 |
| Density: | 1.2962 (rough estimate) |
| Melting Point: | ca. 248 - 250 C (decomposes) |
| Solubility: | slight |
| Appearance: | yellow crystals or powder |
| Hazard Symbols: | Xn |
| Risk Codes: | 22-36/37/38 |
| Safety: | Poison by ingestion, subcutaneous, intrauterine, intravenous, and intraperitoneal routes. Human reproductive effects by intrauterine and intracervical routes: changes in fertility and unspecified effects on the uterus, cervix and vagina. Experimental reproductive effects. Mutation data reported. Used as a treatment for parasitic worms. When heated to decomposition it emits very toxic fumes of Cl− and NOx. |
| PSA: | 37.39000 |
| LogP: | 6.84740 |
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Chemistry
Product Name: 6-Chloro-9-((4-(diethylamino)-1-methylbutyl)amino)-2-methoxyacridine dihydrochloride (CAS NO.69-05-6)
Molecular Formula: C23H32Cl3N3O
Molecular Weight: 472.88g/mol
Mol File: 69-05-6.mol
Einecs: 200-700-8
Appearance: Yellow crystals or powder
Boiling point: 557.1 °C at 760 mmHg
Flash Point: 290.7 °C
Water Solubility: Soluble
Enthalpy of Vaporization: 83.88 kJ/mol
Vapour Pressure: 1.9E-12 mmHg at 25°C
H-Bond Donor: 3
H-Bond Acceptor: 4
Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| cat | LDLo | intravenous | 10mg/kg (10mg/kg) | SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS | Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 170, Pg. 328, 1933. |
| cat | LDLo | oral | 200mg/kg (200mg/kg) | BEHAVIORAL: EXCITEMENT GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" GASTROINTESTINAL: OTHER CHANGES | Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 170, Pg. 328, 1933. |
| cat | LDLo | subcutaneous | 100mg/kg (100mg/kg) | GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" KIDNEY, URETER, AND BLADDER: OTHER CHANGES LIVER: OTHER CHANGES | Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 170, Pg. 328, 1933. |
| dog | LDLo | intravenous | 20mg/kg (20mg/kg) | PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE) VASCULAR: OTHER CHANGES LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES | Journal of the American Pharmaceutical Association, Scientific Edition. Vol. 34, Pg. 20, 1945. |
| gerbil | LDLo | intraperitoneal | 70mg/kg (70mg/kg) | Contraception. Vol. 17, Pg. 231, 1978. | |
| guinea pig | LD50 | intravenous | 14mg/kg (14mg/kg) | BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD | Journal of Pharmacology and Experimental Therapeutics. Vol. 91, Pg. 157, 1947. |
| hamster | LDLo | intraperitoneal | 80mg/kg (80mg/kg) | Contraception. Vol. 17, Pg. 231, 1978. | |
| man | TDLo | oral | 34mg/kg/8D-I (34mg/kg) | BEHAVIORAL: TOXIC PSYCHOSIS | Southern Medical Journal. Vol. 75, Pg. 359, 1982. |
| monkey | LDLo | intravenous | 15mg/kg (15mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION | Contraception. Vol. 24, Pg. 269, 1981. |
| mouse | LD50 | intraperitoneal | 189mg/kg (189mg/kg) | Journal of Pharmacology and Experimental Therapeutics. Vol. 91, Pg. 133, 1947. | |
| mouse | LD50 | intravenous | 38mg/kg (38mg/kg) | BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD | Journal of Pharmacology and Experimental Therapeutics. Vol. 91, Pg. 157, 1947. |
| mouse | LD50 | oral | 557mg/kg (557mg/kg) | Journal of Pharmacology and Experimental Therapeutics. Vol. 91, Pg. 157, 1947. | |
| mouse | LD50 | subcutaneous | 212mg/kg (212mg/kg) | LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION | Annals of Biochemistry and Experimental Medicine. Vol. 1, Pg. 317, 1941. |
| rabbit | LD50 | intravenous | 9mg/kg (9mg/kg) | BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) | Journal of Pharmacology and Experimental Therapeutics. Vol. 91, Pg. 157, 1947. |
| rabbit | LD50 | oral | 433mg/kg (433mg/kg) | Journal of Pharmacology and Experimental Therapeutics. Vol. 91, Pg. 157, 1947. | |
| rat | LD50 | intrauterine | 100mg/kg (100mg/kg) | Indian Journal of Experimental Biology. Vol. 16, Pg. 1074, 1978. | |
| rat | LD50 | intravenous | 29mg/kg (29mg/kg) | BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD | Journal of Pharmacology and Experimental Therapeutics. Vol. 91, Pg. 157, 1947. |
| rat | LD50 | oral | 660mg/kg (660mg/kg) | Journal of Pharmacology and Experimental Therapeutics. Vol. 91, Pg. 157, 1947. | |
| women | TDLo | oral | 18mg/kg/3D-I (18mg/kg) | BEHAVIORAL: TOXIC PSYCHOSIS | Southern Medical Journal. Vol. 75, Pg. 359, 1982. |
Consensus Reports
EPA Genetic Toxicology Program.
Safety Profile
Poison by ingestion, subcutaneous, intrauterine, intravenous, and intraperitoneal routes. Human reproductive effects by intrauterine and intracervical routes: changes in fertility and unspecified effects on the uterus, cervix and vagina. Experimental reproductive effects. Mutation data reported. Used as a treatment for parasitic worms. When heated to decomposition it emits very toxic fumes of Cl− and NOx.
Safety Information of 6-Chloro-9-((4-(diethylamino)-1-methylbutyl)amino)-2-methoxyacridine dihydrochloride (CAS NO.69-05-6):
Hazard Codes: Xn.gif){kind=small}
Risk Statements: 22-36/37/38
22: Harmful if swallowed
36: Irritating to the eyes
37: Irritating to the respiratory system
38: Irritating to the skin
Safety Statements: 36/37/39
36: Wear suitable protective clothing
37: Wear suitable gloves
39: Wear eye/face protection
Specification
6-Chloro-9-((4-(diethylamino)-1-methylbutyl)amino)-2-methoxyacridine dihydrochloride ,its CAS NO. is 69-05-6,the synonyms is Quinacrine dihydrochloride ; 6-Chloro-9-(4-diethylamino-1-methyl-butylamino)-2-methoxyacridine dihydrochloride ; 6-Chloro-9-(4-diethylamino-1-methyl-n-butyl)amino-2-methoxyacridine dihydrochloride ; Metochin hydrochloride ; Mepacrine ; Mepacrine dihydrochloride ; Erion hydrochloride ; Dl-quinacrine hydrochloride ; Chinacrin hydrochloride .