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CAS No.: | 69956-77-0 |
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Name: | Pelubiprofen |
Molecular Structure: | |
Formula: | C16H18 O3 |
Molecular Weight: | 258.317 |
Synonyms: | Benzeneaceticacid, a-methyl-4-[(2-oxocyclohexylidene)methyl]-,(E)-; (?à)-p-[[(E)-2-Oxocyclohexylidene]methyl]hdratropicacid; CS 670; Pelubiprofen; RS 2131 |
Density: | 1.199g/cm3 |
Boiling Point: | 457.4°C at 760 mmHg |
Flash Point: | 244.5°C |
PSA: | 54.37000 |
LogP: | 3.40120 |
4-cyclohexen-1-ylmorpholine
ethyl 2-(4-formylphenyl)propionate
2-[4-(2-oxo-1-cyclohexyliden methyl)-phenyl]propionic acid
Conditions | Yield |
---|---|
With hydrogenchloride; potassium carbonate Yield given. Multistep reaction; |
(S)-1-phenyl-ethylamine
2-[4-(2-oxo-1-cyclohexyliden methyl)-phenyl]propionic acid
A
(-)-N-<(1S)-1-Phenylethyl>-(2S)-<4-(2-oxocyclohexylidenemethyl)phenyl>propionamide
B
(-)-N-<(1S)-1-Phenylmethyl>-(2R)-<4-(2-oxocyclohexylidenemethyl)phenyl>propionamide
Conditions | Yield |
---|---|
With 2,2'-dipyridyldisulphide; triphenylphosphine In dichloromethane at 0℃; for 0.5h; | A 0.75 g B 0.8 g |
2-[4-(2-oxo-1-cyclohexyliden methyl)-phenyl]propionic acid
(+)-(2S)-2-<4-(2-Oxocyclohexylidenemethyl)phenyl>propionic acid
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 0.75 g / 2,2'-dipyridyl disulfide, triphenylphosphine / CH2Cl2 / 0.5 h / 0 °C 2: 1.) N2O4, sodium acetate / 1.) CCl4, 0 deg C, 2 h, 2.) CCl4, reflux, 1 h View Scheme |
2-[4-(2-oxo-1-cyclohexyliden methyl)-phenyl]propionic acid
(-)-(2R)-2-<4-(2-Oxocyclohexylidenemethyl)phenyl>propionic acid
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 0.8 g / 2,2'-dipyridyl disulfide, triphenylphosphine / CH2Cl2 / 0.5 h / 0 °C 2: 1.) N2O4, sodium acetate / 1.) CCl4, 0 deg C, 2 h, 2.) CCl4, reflux, 1 h View Scheme |