Name: cis-4-isopropylcyclohexanecarboxylic acid
SKU: 7084-93-7

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Basic Information

Molecular Structure:
CAS No.:	7084-93-7
Name:	cis-4-isopropylcyclohexanecarboxylic acid

Formula:	C10H18 O2
Molecular Weight:	170.252
Synonyms:	Cyclohexanecarboxylicacid, 4-isopropyl-, cis- (8CI); cis-4-Isopropylcyclohexanecarboxylic acid;cis-p-Menthan-7-oic acid
Density:	0.996g/cm³
Boiling Point:	263.8°C at 760 mmHg
Flash Point:	126.9°C
PSA:	37.30000
LogP:	2.53340

Synthetic route

Conditions	Yield
With sodium hydroxide In methanol for 0.166667h; Ambient temperature;	64%

Conditions	Yield
With sodium hydroxide; nickel at 195℃; under 73550.8 Torr; Hydrogenation;
With sodium hydroxide; nickel at 200℃; under 110326 - 147102 Torr; Hydrogenation;
With acetic acid; platinum Hydrogenation;
With hydrogen at 80℃; under 7600.51 Torr; for 36h; Autoclave; Overall yield = 87 %; Overall yield = 148.1 mg;	A n/a B n/a

Conditions	Yield
With sodium hydroxide; sodium hydride 1) 150 deg C, 2 h, 2) MeOH, 20 deg C, 10 min; Yield given. Multistep reaction;
With sodium phosphate buffer; lipase from Candida rugosa for 6.5h; pH 7.2; Yield given. Yields of byproduct given. Title compound not separated from byproducts;

Conditions	Yield
With acetic acid; platinum Hydrogenation;

Conditions	Yield
Hydrogenation;

Conditions	Yield
Multi-step reaction with 2 steps 1: 1) H2, 2) SOCl2 / 1) PtO2 / 1) 5 kg/cm2, r.t., 2 h 2: 64 percent / 2N aq. NaOH / methanol / 0.17 h / Ambient temperature View Scheme

: 3-(5-amino-2-methylphenyl)-7-((3-amino-4-methylphenyl)-amino)-1-methyl-3,4-dihydropyrimido[4,5-d]pyrimidin-2(1H)-one

: N-(3-(7-(3-amino-4-methylphenylamino)-1-methyl-2-oxo-1,2-dihydropyrimido[4,5-d]pyrimidin-3(4H)-yl)-4-methylphenyl)-4-isopropylcyclohexanecarboxamide

Conditions	Yield
With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In N,N-dimethyl-formamide at 20℃; for 14h; Inert atmosphere;	48%