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CAS No.: | 71-62-5 |
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Name: | VERATRIDINE |
Molecular Structure: | |
Formula: | C36H51 N O11 |
Molecular Weight: | 673.801 |
Synonyms: | Veratridine(6CI,7CI,8CI); 2H-4,16a-Epoxybenzo[7,8]fluoreno[2,1-b]quinolizine,cevane-3,4,12,14,16,17,20-heptol deriv.; 3-Veratroylveracevine; NSC 7524;Veracevine, veratrate; Veratrine; Veratrine (amorphous) |
EINECS: | 200-758-4 |
Density: | 1.45 g/cm3 |
Melting Point: | 180oC |
Boiling Point: | 814.5 °C at 760 mmHg |
Flash Point: | 446.4 °C |
Solubility: | ethanol: 50 mg/mL |
Appearance: | powder |
Hazard Symbols: | T+ |
Risk Codes: | 26/27/28-36/37/38 |
Safety: | Poison by intraperitoneal, subcutaneous, and intravenous routes. Combustible when exposed to heat or flame. When heated to decomposition it emits toxic fumes of NOx. See also VERATRINE. |
Transport Information: | UN 1544 6 |
PSA: | 178.61000 |
LogP: | 1.29390 |
Conditions | Yield |
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With pyridine; benzene |
Conditions | Yield |
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With cation-exchange resin Dowex 50Wx4 at 55 - 70℃; for 27h; | 14% |
Chemistry informtion about Veratridine (71-62-5) is:
Synonyms: 3-Veratroylveracevine ; Veratridine ; ,4alpha,16beta)- ; 4,9-Epoxycevane-3,4,12,14,16,17,20-Heptol3-(3,4-Dimethoxybenzoate) ; Cevane-3,4,12,14,16,17,20-Heptol,4,9-Epoxy-,3-(3,4-Dimethoxybenzoate),(3beta ; Cevane-3-Beta,4-Alpha,12,14,16-Beta,17,20-Heptol,4,9-Epoxy-,3-(3,4-Dimethox;Veratrine(Amorphous) ; Ybenzoate)
MF: C36H51NO11
MW: 673.79
EINECS: 200-758-4
Density: 1.45 g/cm3
Flash Point: 446.4 °C
Boiling Point: 814.5 °C at 760 mmHg
Vapour Pressure: 4.74E-28 mmHg at 25°C
Enthalpy of Vaporization: 124.14 kJ/mol
Storage temp.: −20°C
Solubility ethanol: 50 mg/mL
Form: powder
Merck: 13,10016
Following is the molecular structure of Veratridine (71-62-5) is:
Veratridine (71-62-5) is used in ointments for the treatment of neuralgia and rheumatoid pain.
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
dog | LDLo | intravenous | 19mg/kg (19mg/kg) | cardiac: arrhythmias (including changes in conduction) | Journal of Pharmacology and Experimental Therapeutics. Vol. 120, Pg. 412, 1957. |
mouse | LD50 | intraperitoneal | 1350ug/kg (1.35mg/kg) | Proceedings of the Society for Experimental Biology and Medicine. Vol. 76, Pg. 847, 1951. | |
mouse | LD50 | subcutaneous | 6300ug/kg (6.3mg/kg) | behavioral: convulsions or effect on seizure threshold lungs, thorax, or respiration: cyanosis behavioral: ataxia | Journal of Pharmacology and Experimental Therapeutics. Vol. 113, Pg. 89, 1955. |
rat | LD50 | intraperitoneal | 3500ug/kg (3.5mg/kg) | lungs, thorax, or respiration: cyanosis lungs, thorax, or respiration: respiratory depression gastrointestinal: changes in structure or function of salivary glands | Journal of Pharmacology and Experimental Therapeutics. Vol. 78, Pg. 238, 1943. |
Poison by intraperitoneal, subcutaneous, and intravenous routes. Combustible when exposed to heat or flame. When heated to decomposition it emits toxic fumes of NOx. See also VERATRINE.
Hazard Codes:
T+: Very toxic
Risk Statements:
R26/27/28: Very toxic by inhalation, in contact with skin and if swallowed.
R36/37/38: Irritating to eyes, respiratory system and skin.
Safety Statements:
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36/37/39: Wear suitable protective clothing, gloves and eye/face protection.
S45: In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
RIDADR: UN 1544 6.1/PG 1
WGK Germany: 2
RTECS: YX5600000
F:
F 10: Keep under argon.
HazardClass: 6.1(a)
PackingGroup: II
Veratridine (71-62-5) is a steroid-derived alkaloid from the family of Liliaceae that functions as a neurotoxin by activating sodium ion channels. It is a derivative of veracevine. It is primarily obtained from the herb Veratrum and sabadilla seeds. Its color is white to off-white.