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71653-63-9

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Basic Information
CAS No.: 71653-63-9
Name: Riodipine
Article Data: 4
Molecular Structure:
Molecular Structure of 71653-63-9 (Riodipine)
Formula: C18H19 F2 N O5
Molecular Weight: 367.349
Synonyms: 3,5-Pyridinedicarboxylicacid, 4-[2-(difluoromethoxy)phenyl]-1,4-dihydro-2,6-dimethyl-, dimethyl ester(9CI);Foridon;Foridone;PP 1466;Riodipine;
Density: 1.242g/cm3
Melting Point: 157°C
Boiling Point: 445.4°C at 760 mmHg
Flash Point: 223.2°C
Safety: Poison by ingestion and intraperitoneal routes. When heated to decomposition it emits toxic fumes of F− and NOx.
PSA: 73.86000
LogP: 3.19760
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    dimethyl4-[2-(difluoromethoxy)phenyl]-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate

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    Riodipine

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Chemistry

 Ryodipine with CAS register number of 71653-63-9 is also called as Riodipine ; Foridon ; Riodipinum ; Foridone ; Phoridone ; Riodipino ; Riodipinum [Latin] ,and so on.
IUPAC Name: Dimethyl-4-[2-(difluoromethoxy)phenyl]-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate
CAS: 71653-63-9
Molecular Formula: C18H19F2NO5 
Molecular Weight: 367.344
Molecular structure:
ACD/LogD (pH 5.5):  3.33 
ACD/LogD (pH 7.4):  3.33 
ACD/BCF (pH 5.5):  199.65 
ACD/BCF (pH 7.4):  200.14 
ACD/KOC (pH 5.5):  1541.1 
ACD/KOC (pH 7.4):  1544.89 
H bond acceptors:  6 
H bond donors:  1 
Freely Rotating Bonds:  7 
Index of Refraction:  1.509 
Molar Refractivity:  88.32 cm3 
Molar Volume:  295.7 cm3 
Polarizability:  35.01×10-24cm3 
Surface Tension:  36.5 dyne/cm 
Density:  1.242 g/cm3 
Flash Point:  223.2 °C 
Enthalpy of Vaporization:  70.34 kJ/mol 
Boiling Point:  445.4 °C at 760 mmHg 
Vapour Pressure:  3.97E-08 mmHg at 25°C 

Uses

 Ryodipine (CAS No.71653-63-9) is mainly used as a calcium channel blocker.

Toxicity Data With Reference

1.    

orl-rat LD50:11 g/kg

     ARZNAD    Arzneimittel-Forschung. Drug Research. 35 (1985),672.
2.    

orl-mus LD50:721 mg/kg

     ARZNAD    Arzneimittel-Forschung. Drug Research. 35 (1985),672.
3.    

ipr-mus LD50:395 mg/kg

     PCJOAU    Pharmaceutical Chemistry Journal (English Translation). Translation of KHFZAN. 16 (1982),817.
4.    

orl-dog LD50:1198 mg/kg

     ARZNAD    Arzneimittel-Forschung. Drug Research. 35 (1985),915.
5.    

orl-rbt LD50:209 mg/kg

     ARZNAD    Arzneimittel-Forschung. Drug Research. 35 (1985),915.

Safety Profile

 Ryodipine (CAS No.71653-63-9) is poisonous by ingestion and intraperitoneal routes. When heated to decomposition it emits toxic fumes of F− and NOx.