CAS No.72040-63-2,Succinimidyl 6-(biotinamido)hexanoate Suppliers

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Basic Information

Molecular Structure:
CAS No.:	72040-63-2
Name:	Succinimidyl 6-(biotinamido)hexanoate
Article Data:	2

Formula:	C₂₀H₃₀N₄O₆S
Molecular Weight:	454.547
Synonyms:	1H-Thieno[3,4-d]imidazole-4-pentanamide,N-[6-[(2,5-dioxo-1-pyrrolidinyl)oxy]-6-oxohexyl]hexahydro-2-oxo-, (3aS,4S,6aR)-(9CI);1H-Thieno[3,4-d]imidazole-4-pentanamide,N-[6-[(2,5-dioxo-1-pyrrolidinyl)oxy]-6-oxohexyl]hexahydro-2-oxo-, [3aS-(3aa,4b,6aa)]-;5-(N-Succinimidyloxycarbonyl)pentyl d-biotinamide;6-[(Biotinyl)amino]hexanoic acid N-hydroxysuccinimide ester;B 1582;Biotin-LC-NHS;Biotin-X, SE;D-(+)-Biotinyl-e-aminocaproic acid N-hydroxysuccimide ester;EZ-LinkNHS-LC-Biotin;N-Hydroxysuccinimidyl 6-(biotinamido)hexanoate;N-Hydroxysuccinimidyl biotinamidocaproate;N-[5-(Succinimidyloxycarbonyl)pentyl]biotin amide;NHS-LC-biotin;Succinimidyl-6-(biotinamido) hexanoate;
Density:	1.35 g/cm³
Melting Point:	169-171 °C
Solubility:	H₂O: ≤2 mg/mL with sonication
Appearance:	White solid
Safety:	24/25
PSA:	159.21000
LogP:	1.98240

Synthetic route

: 6066-82-6
1-hydroxy-pyrrolidine-2,5-dione

: 72040-64-3
6-[5-(2-oxo-hexahydro-thieno[3,4-d]imidazol-4-yl)-pentanoylamino]-hexanoic acid

: 72040-63-2
6-[5-(2-oxo-hexahydro-thieno[3,4-d]imidazol-4-yl)-pentanoylamino]-hexanoic acid 2,5-dioxo-pyrrolidin-1-yl ester

Conditions

Conditions	Yield
Stage #1: 6-[5-(2-oxo-hexahydro-thieno[3,4-d]imidazol-4-yl)-pentanoylamino]-hexanoic acid With pyridine; dicyclohexyl-carbodiimide In N,N-dimethyl-formamide at 20℃; for 0.0833333h; Stage #2: 1-hydroxy-pyrrolidine-2,5-dione In N,N-dimethyl-formamide for 18h;	56.8%

: 4443-68-9, 5652-41-5, 57378-70-8
biotin

: 72040-63-2
6-[5-(2-oxo-hexahydro-thieno[3,4-d]imidazol-4-yl)-pentanoylamino]-hexanoic acid 2,5-dioxo-pyrrolidin-1-yl ester

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1.1: pyridine; dicyclohexyl-carbodiimide / N,N-dimethyl-formamide / 0.08 h / 20 °C 1.2: 24 h / 20 °C 2.1: N,N-dimethyl-formamide / 4 h / 20 °C / pH 8 / sodium bicarbonate buffer 3.1: pyridine; dicyclohexyl-carbodiimide / N,N-dimethyl-formamide / 0.08 h / 20 °C 3.2: 18 h View Scheme

: 85718-04-3
biotin N-hydroxysuccinimide ester

: 72040-63-2
6-[5-(2-oxo-hexahydro-thieno[3,4-d]imidazol-4-yl)-pentanoylamino]-hexanoic acid 2,5-dioxo-pyrrolidin-1-yl ester

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1.1: N,N-dimethyl-formamide / 4 h / 20 °C / pH 8 / sodium bicarbonate buffer 2.1: pyridine; dicyclohexyl-carbodiimide / N,N-dimethyl-formamide / 0.08 h / 20 °C 2.2: 18 h View Scheme

: 60-32-2
6-aminohexanoic acid

: 72040-63-2
6-[5-(2-oxo-hexahydro-thieno[3,4-d]imidazol-4-yl)-pentanoylamino]-hexanoic acid 2,5-dioxo-pyrrolidin-1-yl ester

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1.1: N,N-dimethyl-formamide / 4 h / 20 °C / pH 8 / sodium bicarbonate buffer 2.1: pyridine; dicyclohexyl-carbodiimide / N,N-dimethyl-formamide / 0.08 h / 20 °C 2.2: 18 h View Scheme

: 51857-17-1
tert-butyl N-(6-aminohexyl)carbamate

: 72040-63-2
6-[5-(2-oxo-hexahydro-thieno[3,4-d]imidazol-4-yl)-pentanoylamino]-hexanoic acid 2,5-dioxo-pyrrolidin-1-yl ester

: (6-{6-[5-(2-oxo-hexahydro-thieno[3,4-d]imidazol-4-yl)-pentanoylamino]-hexanoylamino}-hexyl)-carbamic acid tert-butyl ester

Conditions

Conditions	Yield
With triethylamine In N,N-dimethyl-formamide at 20℃;	93.8%

: 1333155-97-7
9-(3-aminopropyl)-8-((6-iodobenzo[d][1,3]dioxol-5-yl)thio)-9H-purin-6-amine

: 72040-63-2
6-[5-(2-oxo-hexahydro-thieno[3,4-d]imidazol-4-yl)-pentanoylamino]-hexanoic acid 2,5-dioxo-pyrrolidin-1-yl ester

: 1418215-40-3
C31H40IN9O5S2

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 1h;	72%

: 8-(6-iodo-benzo[1,3]dioxol-5-ylsulfanyl)-9-(3-isopropylamino-propyl)adenine

: 72040-63-2
6-[5-(2-oxo-hexahydro-thieno[3,4-d]imidazol-4-yl)-pentanoylamino]-hexanoic acid 2,5-dioxo-pyrrolidin-1-yl ester

: 1418215-42-5
C34H46IN9O5S2

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 35℃; for 6h;	41%

: N-(4-azido-2-nitrobenzoyl)-1,7-diaminoheptane

: 72040-63-2
6-[5-(2-oxo-hexahydro-thieno[3,4-d]imidazol-4-yl)-pentanoylamino]-hexanoic acid 2,5-dioxo-pyrrolidin-1-yl ester

: 4-Azido-2-nitro-N-(7-{6-[5-(2-oxo-hexahydro-thieno[3,4-d]imidazol-6-yl)-pentanoylamino]-hexanoylamino}-heptyl)-benzamide

Conditions

Conditions	Yield
In N,N-dimethyl-formamide

: 72040-63-2
6-[5-(2-oxo-hexahydro-thieno[3,4-d]imidazol-4-yl)-pentanoylamino]-hexanoic acid 2,5-dioxo-pyrrolidin-1-yl ester

: 5-(3-aminopropen-1-yl)-5'-O-(β,γ-diphosphoryl-α-phosphonomethyl)-2'-deoxyuridine

: 5-[3-(N-biotinyl-6-aminohexanoylamino)propen-1-yl]-5'-O-(β,γ-diphosphoryl-α-phosphonomethyl)-2'-deoxyuridine

Conditions

Conditions	Yield
With 1-methyl-1H-imidazole; triethylamine In N,N-dimethyl-formamide

: 34284-75-8
4-(2-aminoethyl)benzenesulfonyl fluoride

: 72040-63-2
6-[5-(2-oxo-hexahydro-thieno[3,4-d]imidazol-4-yl)-pentanoylamino]-hexanoic acid 2,5-dioxo-pyrrolidin-1-yl ester

: 4-(2-{6-[5-(2-oxo-hexahydro-thieno[3,4-d]imidazol-6-yl)-pentanoylamino]-hexanoylamino}-ethyl)-benzenesulfonyl fluoride

Conditions

Conditions	Yield
In dimethyl sulfoxide at 20℃;

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Chemistry

IUPAC Name: (2,5-Dioxopyrrolidin-1-yl)6-[5-[(3aR,6S,6aS)-2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-6-yl]pentanoylamino]hexanoate
Molecular Formula: C₂₀H₃₀N₄O₆S
Molecular Weight: 454.54
Density: 1.35 g/cm³
Melting Point: 169-171 ºC
Freely Rotating Bonds: 13
Polar Surface Area: 132.84 Å²
Index of Refraction: 1.591
Molar Refractivity: 113.63 cm³
Molar Volume: 336.2 cm³
Polarizability: 45.04× 10^-24 cm³
Surface Tension: 62.7 dyne/cm
The Cas Register Number of Biotin-x-nhs is 72040-63-2.The chemical synonyms of Biotin-x-nhs (CAS NO.72040-63-2) are 6-[5-(2-Oxo-hexahydro-thieno[3,4-d]imidazol-4-yl)-pentanoylamino]-hexanoic acid 3-hydroperoxysulfonyl-2,5-dioxo-pyrrolidin-1-yl ester sodium salt ; 6-((Biotinoyl)amino)hexanoic acid, succinimidyl ester ; 6-[(+)-Biotinyl]aminocaproic acid n-hydroxysuccinimde ester ; d-Biotin-amidocaproate-n-hydroxysuccinimide ester ; d-Biotinoyl-epsilon-aminocaproic acid-n-hydroxysuccinimide ester ; d-Biotinyl-epsilon-aminocaproic acid-n-hydroxy-succinimide ester ; Biotinyl-epsilon-aminocaproic acid-n-hydroxysuccinimide ester ; Biotin-x-nhs .Product categories of Biotin-x-nhs (CAS NO.72040-63-2) are API intermediates ; Biotin Derivatives ; Cross Linking Reagents ; Labeling and Diagnostics Reagents ; Sulfur and Selenium Compounds .The molecular structure of Biotin-x-nhs (CAS NO.72040-63-2) is.

Uses

It has been used to biotinylate both the antibody and the carrier in the Protein Avidin-Biotin solid surface.

Safety Profile

WGK Germany: 3
F: 10-21
F 10: Keep under argon.
F 21: Sensitive to humidity.