Name: Tiglic acid
SKU: 80-59-1

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Basic Information

Molecular Structure:
CAS No.:	80-59-1
Name:	Tiglic acid

Formula:	C₅H₈O₂
Molecular Weight:	100.117
Synonyms:	2-Butenoicacid, 2-methyl-, (E)-;Crotonic acid, 2-methyl-, (E)- (8CI);Tiglic acid(6CI,7CI);(E)-2-Methyl-2-butenoic acid;(E)-a-Methylcrotonic acid;Cevadic acid;NSC 44235;NSC 8999;trans-2,3-Dimethylacrylic acid;trans-2-Methyl-2-butenoic acid;trans-a,b-Dimethylacrylic acid;
EINECS:	201-295-0
Density:	1.01 g/cm³
Melting Point:	61-64 °C(lit.)
Boiling Point:	198.499 °C at 760 mmHg
Flash Point:	95.95 °C
Solubility:	Easily soluble in hot water; soluble in ethanol and aether; slightly soluble in cold water
Appearance:	white to beige crystalline powder and chunks
Hazard Symbols:	C,Xi
Risk Codes:	34-36/37/38
Safety:	26-36/37/39-45-24/25-27
Transport Information:	UN 3261 8/PG 2
PSA:	37.30000
LogP:	1.03720

Synthetic route

: 1400908-83-9
(S)-12-hydroxypentadecanoic acid 12-O-(6-O-(S)-2-methylbutyryl)-β-D-glucopyranosyl-(1->3)-O-[4-O-tigloyl-α-L-rhamnopyranosyl-(1->4)]-O-[2-O-(S)-2-methylbutyryl]-α-L-rhamnopyranosyl-(1->4)-O-α-L-rhamnopyranosyl-(1->2)-β-D-glucopyranoside

A: 116-53-0, 600-07-7
2-Methylbutanoic acid

B: 80-59-1
Tiglic acid

C: 1400908-78-2
(S)-12-hydroxypentadecanoic acid 12-O-β-D-glucopyranosyl-(1->3)-O-[α-L-rhamnopyranosyl-(1->4)]-O-α-L-rhamnopyranosyl-(1->4)-O-α-L-rhamnopyranosyl-(1->2)-β-D-glucopyranoside

Conditions

Conditions	Yield
With potassium hydroxide at 85℃; for 4h; pH=4;	A 98% B 98% C 3 mg

...Expand

: 1400908-85-1
turpethoside acid B

A: 116-53-0, 600-07-7
2-Methylbutanoic acid

B: 80-59-1
Tiglic acid

C: 1400908-79-3
(S)-12-hydroxyhexadecanoic acid 12-O-β-D-glucopyranosyl-(1->3)-O-[α-L-rhamnopyranosyl-(1->4)]-O-α-L-rhamnopyranosyl-(1->4)-O-α-L-rhamnopyranosyl-(1->2)-β-D-glucopyranoside

Conditions

Conditions	Yield
With potassium hydroxide at 85℃; for 4h; pH=4;	A 98% B 98% C 3 mg

...Expand

: 3017-71-8
(E)-2-bromobut-2-ene

: 201230-82-2
carbon monoxide

: 80-59-1
Tiglic acid

Conditions

Conditions	Yield
With sodium hydroxide; cetyltrimethylammonim bromide; nickel cyanide In toluene at 95℃; under 735.5 Torr; for 6h;	89%
With calcium hydroxide; methyl iodide; dicobalt octacarbonyl In 1,4-dioxane; water at 20℃; under 760 Torr; for 20h;	88 % Chromat.

: 15226-74-1, 61091-28-9, 61117-58-6
dicobalt octacarbonyl

: 3017-71-8
(E)-2-bromobut-2-ene

: 80-59-1
Tiglic acid

Conditions

Conditions	Yield
With calcium hydroxide; carbon monoxide; methyl iodide In 1,4-dioxane; water 20°C, 20 h.;	88%

: 15226-74-1, 61091-28-9, 61117-58-6
dicobalt octacarbonyl

: 3017-68-3
(Z)-2-Bromo-2-butene

: 80-59-1
Tiglic acid

Conditions

Conditions	Yield
With calcium hydroxide; carbon monoxide; methyl iodide In 1,4-dioxane; water 20°C, 20 h.;	87%

Cp2TiOOC(trans-C(CH3)=CHCH3): Cp2TiOOC(trans-C(CH3)=CHCH3)

: 80-59-1
Tiglic acid

Conditions

Conditions	Yield
With water In diethyl ether for 1h; Ambient temperature;	85%

: 1567-73-3
(E)-3-methylpent-3-en-2-one

: 80-59-1
Tiglic acid

Conditions

Conditions	Yield
With sodium hypochlorite solution; sodium hydroxide at 55 - 60℃; for 1h; Large scale;	84.3%

: 3739-30-8
2-hydroxy-2-methylbutyric acid

: 80-59-1
Tiglic acid

Conditions

Conditions	Yield
With sulfuric acid at 140℃;	76.5%
Erhitzen;
With sulfuric acid at 115 - 130℃; im geschlossenen Rohr;

: 73758-54-0
2-chloro-2-methylbutyric acid

: 80-59-1
Tiglic acid

Conditions

Conditions	Yield
With potassium hydroxide In ethanol for 6h; Reflux;	70%

: 3586-58-1
2-methylenebutyric acid

: 80-59-1
Tiglic acid

Conditions

Conditions	Yield
With water at 230℃; for 3h;	62%
With sulfuric acid

Raw Materials

526-13-6

639-11-2

Downstream Products

127-17-3

503-74-2

75-07-0

78-93-3

Total:84 Page 1 of 3 1 2 3 Next>>

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Specification

The Tiglic acid, with the CAS registry number 80-59-1, is also known as trans-2,3-Dimethylacrylic acid. It belongs to the product categories of Aromatic Cinnamic Acids, Esters and Derivatives. Its EINECS number is 201-295-0. This chemical's molecular formula is C₅H₈O₂ and molecular weight is 100.12. What's more, its systematic name is (2E)-2-Methyl-2-butenoic acid. Its classification code is Skin / Eye Irritant. This chemical should be sealed and stored in a cool place. It is used as demulsifying agent and pharmaceutical intermediates. This substance is a volatile and crystallizable substance with a sweet, warm spicy odour. It is used in making perfumes and flavoring agents. The salts and esters of tiglic acid are called tiglates.

Physical properties of Tiglic acid are: (1)ACD/LogP: 1.076; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): 0.49; (4)ACD/LogD (pH 7.4): -1.27; (5)ACD/BCF (pH 5.5): 1.00; (6)ACD/BCF (pH 7.4): 1.00; (7)ACD/KOC (pH 5.5): 23.70; (8)ACD/KOC (pH 7.4): 1.00; (9)#H bond acceptors: 2; (10)#H bond donors: 1; (11)#Freely Rotating Bonds: 1; (12)Polar Surface Area: 37.3 Å²; (13)Index of Refraction: 1.451; (14)Molar Refractivity: 26.678 cm³; (15)Molar Volume: 99.111 cm³; (16)Polarizability: 10.576×10^-24cm³; (17)Surface Tension: 32.29 dyne/cm; (18)Density: 1.01 g/cm³; (19)Flash Point: 95.95 °C; (20)Enthalpy of Vaporization: 47.913 kJ/mol; (21)Boiling Point: 198.499 °C at 760 mmHg; (22)Vapour Pressure: 0.15 mmHg at 25°C.

Preparation: this chemical can be prepared by 2-ethyl-acrylic acid at the temperature of 230 °C. This reaction will need reagent water with the reaction time of 3 hours. The yield is about 62%.

Tiglic acid can be prepared by 2-ethyl-acrylic acid at the temperature of 230 °C

Uses of Tiglic acid: it can be used to produce (E)-2-methyl-but-2-enoic acid methyl ester by heating. It will need reagent conc. H₂SO₄ with the reaction time of 24 hours. The yield is about 70%.

Tiglic acid can be used to produce (E)-2-methyl-but-2-enoic acid methyl ester by heating

When you are using this chemical, please be cautious about it as the following:
This chemical can cause burns. It is irritating to eyes, respiratory system and skin. You should take off immediately all contaminated clothing. In case of contact with eyes, you should rinse immediately with plenty of water and seek medical advice. When using it, you need to wear suitable protective clothing, gloves and eye/face protection and avoid contact with skin and eyes. In case of accident or if you feel unwell, you should seek medical advice immediately (show the label where possible).

You can still convert the following datas into molecular structure:
(1)SMILES: O=C(O)/C(=C/C)C
(2)Std. InChI: InChI=1S/C5H8O2/c1-3-4(2)5(6)7/h3H,1-2H3,(H,6,7)/b4-3+
(3)Std. InChIKey: UIERETOOQGIECD-ONEGZZNKSA-N

The toxicity data is as follows:

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
rabbit	LD50	skin	> 5gm/kg (5000mg/kg)		Food and Chemical Toxicology. Vol. 20, Pg. 837, 1982.
rat	LD50	oral	> 5gm/kg (5000mg/kg)		Food and Chemical Toxicology. Vol. 20, Pg. 837, 1982.

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Specification