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| CAS No.: | 82005-12-7 |
|---|---|
| Name: | 10Z-HYMENIALDISINE |
| Article Data: | 5 |
| Molecular Structure: | |
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| Formula: | C11H10BrN5O2 |
| Molecular Weight: | 324.137 |
| Synonyms: | Pyrrolo[2,3-c]azepin-8(1H)-one,4-(2-amino-1,5-dihydro-5-oxo-4H-imidazol-4-ylidene)-2-bromo-4,5,6,7-tetrahydro-,(Z)-;Hymenialdesine;Hymenialdisine; |
| Density: | 2.2 g/cm3 |
| Melting Point: | 160-164oC |
| Solubility: | Soluble in DMSO. |
| Appearance: | Light Yellow Solid |
| PSA: | 112.37000 |
| LogP: | 0.85980 |
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- 926293-55-26-Bromo-2-methylpyridine-3-carboxaldehyde
- Total:12 Page 1 of 1 1
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Specification
The (Z)-Hymenialdisine, with the CAS registry number 82005-12-7, is also known as Pyrrolo(2,3-c)azepin-8(1H)-one,4-(2-amino-1,5-dihydro-5-oxo-4H-imidazol-4-ylidene)-2-bromo-4,5,6,7-tetrahydro-, (4Z)-. It belongs to the product categories of Protein Kinase Inhibitors and Activators; Heterocycles; Tyrosine Kinase Inhibitors. This chemical's molecular formula is C11H10BrN5O2 and molecular weight is 324.13. What's more, it is light yellow solid and it should be kept in a cold and dry place.
Preparation of (Z)-Hymenialdisine: this chemical can be prepared by 4-(2-Amino-3H-imidazol-4-yl)-2,5-dibromo-6,7-dihydro-1H-pyrrolo[2,3-c]azepin-8-one. This reaction needs reagent AcOH at temperature of 120 °C. The reaction time is 48 hours. The yield is 65 %.
![(Z)-Hymenialdisine can be prepared by 4-(2-Amino-3H-imidazol-4-yl)-2,5-dibromo-6,7-dihydro-1H-pyrrolo[2,3-c]azepin-8-one](/UserFilesUpload/Preparation of (Z)-Hymenialdisine.jpg)
Uses of (Z)-Hymenialdisine: (1) it is used as a potent inhibitor of a variety of kinases including MEK-1, GSK-3, and CKI; (2) it also exhibits inhibition of the G2 cell cycle checkpoint at the micromolar concentrations; (3) it is used as a marine sponge alkaloid, a natural product.