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| CAS No.: | 84-22-0 |
|---|---|
| Name: | Tetryzoline |
| Article Data: | 3 |
| Molecular Structure: | |
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| Formula: | C13H16 N2 |
| Molecular Weight: | 200.283 |
| Synonyms: | 2-Imidazoline,2-(1,2,3,4-tetrahydro-1-naphthyl)- (6CI,7CI,8CI); (?à)-Tetrahydrozoline; 2-(1,2,3,4-Tetrahydro-1-naphthyl)-2-imidazoline;Ocuzolin; Tetrahydrozoline; Tetryvil; Tetryzolin; Tetryzoline;dl-Tetrahydrozoline |
| EINECS: | 201-522-3 |
| Density: | 1.2 g/cm3 |
| Melting Point: | 117-119 °C(Solv: heptane (142-82-5); ethanol (64-17-5)) |
| Boiling Point: | 393.5 °C at 760 mmHg |
| Flash Point: | 191.8 °C |
| PSA: | 24.39000 |
| LogP: | 1.87260 |
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Chemistry
Molecular Structure of Tetryzoline (CAS NO.84-22-0):
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IUPAC Name: 2-(1,2,3,4-Tetrahydronaphthalen-1-yl)-4,5-dihydro-1H-imidazole
Molecular Formula: C13H16N2
Molecular Weight: 200.28
EINECS: 201-522-3
Index of Refraction: 1.656
Molar Refractivity: 60.91 cm3
Molar Volume: 165.7 cm3
Surface Tension: 45.9 dyne/cm
Density: 1.2 g/cm3
Flash Point: 191.8 °C
Enthalpy of Vaporization: 61.83 kJ/mol
Boiling Point: 393.5 °C at 760 mmHg
Vapour Pressure: 4.8E-06 mmHg at 25 °C
Classification Code: Autonomic Agents; Cardiovascular Agents; Drug / Therapeutic Agent; Human Data; Nasal decongestants; Peripheral Nervous System Agents; Respiratory System Agents; Sympathomimetics; Vasoconstrictor Agents
Uses
Tetryzoline (CAS NO.84-22-0) is used as nasal decongestant; Visine is a form of eye drops. It is an alpha agonist and its main mechanism of action is the constriction of conjunctival blood vessels. This serves to relieve the redness of the eye caused by minor ocular irritants.
Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| child | TDLo | oral | 150ug/kg (0.15mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS" BEHAVIORAL: IRRITABILITY | Annals of Emergency Medicine. Vol. 20, Pg. 655, 1991. |
| child | TDLo | oral | 186nL/kg (186mL/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) | American Journal of Emergency Medicine. Vol. 2, Pg. 217, 1984. |
| child | TDLo | oral | 375nL/kg (375mL/kg) | BEHAVIORAL: WAKEFULNESS BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) | American Journal of Emergency Medicine. Vol. 2, Pg. 217, 1984. |
| child | TDLo | oral | 1049nL/kg (1049mL/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION KIDNEY, URETER, AND BLADDER: INCONTINENCE | Pediatric Emergency Care. Vol. 15, Pg. 193, 1999. |
| infant | TCLo | inhalation | 60mg/kg (60mg/kg) | SENSE ORGANS AND SPECIAL SENSES: MIOSIS (PUPILLARY CONSTRICTION): EYE BEHAVIORAL: COMA LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION | "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969Vol. -, Pg. 580, 1969. |
| mouse | LD50 | intraperitoneal | 116mg/kg (116mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 12, Pg. 971, 1962. | |
| mouse | LD50 | intravenous | 48100ug/kg (48.1mg/kg) | Drugs in Japan Vol. -, Pg. 699, 1990. | |
| mouse | LD50 | oral | 335mg/kg (335mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 12, Pg. 971, 1962. | |
| mouse | LD50 | subcutaneous | 252mg/kg (252mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 12, Pg. 971, 1962. |
Specification
Tetryzoline (CAS NO.84-22-0), its Synonyms are Tetrahydrozoline ; 1H-Imidazole, 4,5-dihydro-2-(1,2,3,4-tetrahydro-1-naphthalenyl)- ; Tetrahydrozolinum ; Tetrizolina ; Tetryzolin ; Tetryzolinum ; Tyzanol ; 2-Imidazoline, 2-(1,2,3,4-tetrahydro-1-naphthyl)- . Tetryzoline is found in over-the-counter eye drops and nasal sprays which is a derivative of imidazoline.
Excessive use it can lead to poisoning. It can cause severe nausea and vomiting to seizures or a coma and violent diarrhea.