Welcome to LookChem.com Sign In|Join Free
  • or
Home > Pharmaceutical > 866607 > 

866607-35-4

Products Categories

Basic Information
CAS No.: 866607-35-4
Name: D-Glucitol, 1,5-anhydro-1-C-[3-[[5-(4-fluorophenyl)-2-thienyl]Methyl]-4-Methylphenyl]-, tetraacetate, (1S)- (9CI)
Article Data: 20
Molecular Structure:
Molecular Structure of 866607-35-4 (D-Glucitol, 1,5-anhydro-1-C-[3-[[5-(4-fluorophenyl)-2-thienyl]Methyl]-4-Methylphenyl]-, tetraacetate, (1S)- (9CI))
Formula: C32H33FO9S
Molecular Weight: 612.673
Synonyms: D-Glucitol, 1,5-anhydro-1-C-[3-[[5-(4-fluorophenyl)-2-thienyl]Methyl]-4-Methylphenyl]-, tetraacetate, (1S)- (9CI);(2R,3R,4R,5S,6S)-2-(acetoxyMethyl)-6-(3-((5-(4-fluorophenyl)thiophen-2-yl)Methyl)-4-Methylphenyl)tetrahydro-2H-pyran-3,4,5-triyl triacetate;(1S)-1,5-Anhydro-1-C-[3-[[5-(4-fluorophenyl)-2-thienyl]methyl]-4-methylphenyl]-D-glucitol tetraacetate;Canagliflozin Impurity 11;Tetra Acetyl Canagliflozin
Density: 1.32±0.1 g/cm3(Predicted)
Melting Point: 160-170 °C
Boiling Point: 658.3±55.0 °C(Predicted)
PSA: 142.67000
LogP: 5.25150
Related products
Synthetic route
898566-17-1

(2-(4-fluorophenyl)-5-[(5-iodo-2-methylphenyl)methyl]thiophene)

572-09-8

2,3,4,6-tetra-O-acetyl-α-D-glucopyranosyl bromide

866607-35-4

(2R,3R,4R,5S,6S)-2-(acetoxymethyl)-6-(3-((5-(4-fluorophenyl)thiophen-2-yl)methyl)-4-methylphenyl)tetrahydro-2H-pyran-3,4,5-triyl triacetate

Conditions
ConditionsYield
Stage #1: (2-(4-fluorophenyl)-5-[(5-iodo-2-methylphenyl)methyl]thiophene) With isopropylmagnesium chloride In tetrahydrofuran at 0 - 10℃; for 2h; Inert atmosphere;
Stage #2: 2,3,4,6-tetra-O-acetyl-α-D-glucopyranosyl bromide In tetrahydrofuran at -15 - 10℃; for 2h; Reagent/catalyst; Inert atmosphere;		86.2%
With bis(acetylacetonate)nickel(II); magnesium chloride; 4,4',4-tri-tert-butyl-2,2':6',2-terpyridine; zinc In tetrahydrofuran for 20h; Schlenk technique; Inert atmosphere; Cooling with ice;75%
With magnesium chloride In tetrahydrofuran at 15℃; stereoselective reaction;60%

methyl 2,3,4,6-tetra-O-acetyl-1-C-(3-{[5-(4-fluoro-phenyl)-2-thienyl]methyl}-4-methylphenyl)-D-glucopyranoside

866607-35-4

(2R,3R,4R,5S,6S)-2-(acetoxymethyl)-6-(3-((5-(4-fluorophenyl)thiophen-2-yl)methyl)-4-methylphenyl)tetrahydro-2H-pyran-3,4,5-triyl triacetate

Conditions
ConditionsYield
With boron trifluoride diethyl etherate In water; acetonitrile85%
With triethylsilane; trifluoroborane diethyl ether In acetonitrile at 0 - 5℃; for 4h;22 g
With triethylsilane; boron trifluoride diethyl etherate In acetonitrile at 0℃; for 4h;11.12 g
With triethylsilane; boron trifluoride diethyl etherate In water; acetonitrile at 5 - 20℃; Temperature; Large scale;28.6 kg
842133-18-0

canagliflozin

108-24-7

acetic anhydride

866607-35-4

(2R,3R,4R,5S,6S)-2-(acetoxymethyl)-6-(3-((5-(4-fluorophenyl)thiophen-2-yl)methyl)-4-methylphenyl)tetrahydro-2H-pyran-3,4,5-triyl triacetate

Conditions
ConditionsYield
With dmap; triethylamine In ethyl acetate at 20 - 30℃; for 1h;80%
With 4-methyl-morpholine; dmap In tetrahydrofuran at -10 - 20℃; for 1.25h;78%
With 4-methyl-morpholine; dmap In dichloromethane at -5 - 5℃; for 4h; Reagent/catalyst;69.5%
898566-17-1

(2-(4-fluorophenyl)-5-[(5-iodo-2-methylphenyl)methyl]thiophene)

108-24-7

acetic anhydride

32469-28-6, 55515-28-1, 55515-29-2, 32384-65-9

(3R,4S,5R,6R)-3,4,5-tris((trimethylsilyl)oxy)-6-(((trimethylsilyl)oxy)methyl)tetrahydro-2H-pyran-2-one

866607-35-4

(2R,3R,4R,5S,6S)-2-(acetoxymethyl)-6-(3-((5-(4-fluorophenyl)thiophen-2-yl)methyl)-4-methylphenyl)tetrahydro-2H-pyran-3,4,5-triyl triacetate

Conditions
ConditionsYield
Stage #1: (2-(4-fluorophenyl)-5-[(5-iodo-2-methylphenyl)methyl]thiophene) With n-butyllithium In tetrahydrofuran; hexane at -75 - -70℃; for 1h; Inert atmosphere; Large scale;
Stage #2: (3R,4S,5R,6R)-3,4,5-tris((trimethylsilyl)oxy)-6-(((trimethylsilyl)oxy)methyl)tetrahydro-2H-pyran-2-one In tetrahydrofuran; hexane at -60 - 20℃; for 1h; Large scale;
Stage #3: acetic anhydride Large scale; Further stages;		60%
...Expand
1030825-20-7

2-[(5-bromo-2-methyl-phenyl)methyl]-5-(4-fluorophenyl)thiophene

4451-35-8

2,3,4,6-tetra-O-acetyl-α-D-glucopyranosyl chloride

866607-35-4

(2R,3R,4R,5S,6S)-2-(acetoxymethyl)-6-(3-((5-(4-fluorophenyl)thiophen-2-yl)methyl)-4-methylphenyl)tetrahydro-2H-pyran-3,4,5-triyl triacetate

Conditions
ConditionsYield
With nickel(II) bromide dimethoxyethane; diethyl 2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate; [4,4′-bis(1,1-dimethylethyl)-2,2′-bipyridine-N1,N1′]bis{3,5-difluoro-2-[5-(trifluoromethyl)-2-pyridinyl-κN]phenyl-κC}iridium(III) hexafluorophosphate; 4,4'-di-tert-butyl-2,2'-bipyridine; N,N,N',N'-tetramethylguanidine In acetonitrile at 25℃; for 24h; Inert atmosphere; Sealed tube; Irradiation; diastereoselective reaction;48%

((3R,4S,5R,6R)-6-(acetoxymethyl)-2-((5-(4-(fluorophenyl)thiophen-2-yl)methyl)-4-methylphenyl)-2-methoxytetrahydro-2H-pyran-3,4,5-triyl)triacetate

866607-35-4

(2R,3R,4R,5S,6S)-2-(acetoxymethyl)-6-(3-((5-(4-fluorophenyl)thiophen-2-yl)methyl)-4-methylphenyl)tetrahydro-2H-pyran-3,4,5-triyl triacetate

Conditions
ConditionsYield
Stage #1: ((3R,4S,5R,6R)-6-(acetoxymethyl)-2-((5-(4-(fluorophenyl)thiophen-2-yl)methyl)-4-methylphenyl)-2-methoxytetrahydro-2H-pyran-3,4,5-triyl)triacetate With triethylsilane; boron trifluoride diethyl etherate In acetonitrile at 0 - 20℃;
Stage #2: With water; potassium carbonate In acetonitrile at 20℃; Cooling with ice;

(3(R),4(S),5(R)-triacetoxy-6-{3-[5-(4-fluoro-phenyl)-thiophen-2-ylmethyl]-4-methyl-phenyl}-6-hydroxy-tetrahydro-pyran-2(R)-yl)-methanol acetate

866607-35-4

(2R,3R,4R,5S,6S)-2-(acetoxymethyl)-6-(3-((5-(4-fluorophenyl)thiophen-2-yl)methyl)-4-methylphenyl)tetrahydro-2H-pyran-3,4,5-triyl triacetate

Conditions
ConditionsYield
Stage #1: (3(R),4(S),5(R)-triacetoxy-6-{3-[5-(4-fluoro-phenyl)-thiophen-2-ylmethyl]-4-methyl-phenyl}-6-hydroxy-tetrahydro-pyran-2(R)-yl)-methanol acetate With triethylsilane; boron trifluoride diethyl etherate In acetonitrile at 2℃; for 1.5h;
Stage #2: With water; sodium carbonate In acetonitrile at 45℃; Product distribution / selectivity;
1030825-20-7

2-[(5-bromo-2-methyl-phenyl)methyl]-5-(4-fluorophenyl)thiophene

866607-35-4

(2R,3R,4R,5S,6S)-2-(acetoxymethyl)-6-(3-((5-(4-fluorophenyl)thiophen-2-yl)methyl)-4-methylphenyl)tetrahydro-2H-pyran-3,4,5-triyl triacetate

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: n-butyllithium / tetrahydrofuran; toluene; hexane / -75 - -65 °C / Inert atmosphere
1.2: -75 - -70 °C
1.3: 12 h / -75 - 30 °C
2.1: boron trifluoride diethyl etherate; triethylsilane / dichloromethane / 0 - 5 °C
3.1: dmap / acetone / 5 h / 0.25 - 0.5 °C
View Scheme
Multi-step reaction with 4 steps
1.1: sodium iodide; copper(l) iodide; N,N`-dimethylethylenediamine / toluene; diethylene glycol dimethyl ether / 36 h / Inert atmosphere; Reflux
2.1: tetrahydrofuran / 1 h / 0 - 5 °C / Inert atmosphere
2.2: 2 h / 0 - 5 °C
2.3: 2 h / Cooling
3.1: 4-methyl-morpholine; dmap / toluene; ethyl acetate / 15 h / 0 - 20 °C
4.1: triethylsilane; boron trifluoride diethyl etherate / acetonitrile / 4 h / 0 °C
View Scheme
1765-93-1

4-fluoroboronic acid

866607-35-4

(2R,3R,4R,5S,6S)-2-(acetoxymethyl)-6-(3-((5-(4-fluorophenyl)thiophen-2-yl)methyl)-4-methylphenyl)tetrahydro-2H-pyran-3,4,5-triyl triacetate

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: tetrakis(triphenylphosphine) palladium(0); sodium carbonate / 1,2-dimethoxyethane; water / 25 - 75 °C / Inert atmosphere
2.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 0.1 h / 25 - 30 °C / Inert atmosphere
2.2: 0 - 15 °C / Inert atmosphere
3.1: aluminum (III) chloride; sodium tetrahydroborate / 1,2-dimethoxyethane / 0 - 70 °C
4.1: n-butyllithium / tetrahydrofuran; toluene; hexane / -75 - -65 °C / Inert atmosphere
4.2: -75 - -70 °C
4.3: 12 h / -75 - 30 °C
5.1: boron trifluoride diethyl etherate; triethylsilane / dichloromethane / 0 - 5 °C
6.1: dmap / acetone / 5 h / 0.25 - 0.5 °C
View Scheme
58861-48-6

2-(4-fluorophenyl)thiophene

866607-35-4

(2R,3R,4R,5S,6S)-2-(acetoxymethyl)-6-(3-((5-(4-fluorophenyl)thiophen-2-yl)methyl)-4-methylphenyl)tetrahydro-2H-pyran-3,4,5-triyl triacetate

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 0.1 h / 25 - 30 °C / Inert atmosphere
1.2: 0 - 15 °C / Inert atmosphere
2.1: aluminum (III) chloride; sodium tetrahydroborate / 1,2-dimethoxyethane / 0 - 70 °C
3.1: n-butyllithium / tetrahydrofuran; toluene; hexane / -75 - -65 °C / Inert atmosphere
3.2: -75 - -70 °C
3.3: 12 h / -75 - 30 °C
4.1: boron trifluoride diethyl etherate; triethylsilane / dichloromethane / 0 - 5 °C
5.1: dmap / acetone / 5 h / 0.25 - 0.5 °C
View Scheme
Multi-step reaction with 3 steps
1.1: thionyl chloride / dichloromethane; N,N-dimethyl-formamide / 1 h / Reflux
1.2: 1 h / 0 - 30 °C
2.1: s-butylmagnesium chloride; lithium chloride / toluene; tetrahydrofuran / 2 h / -5 - 0 °C
2.2: -45 - -35 °C
3.1: boron trifluoride diethyl etherate; triethylsilane / acetonitrile / 1 h / 30 - 42 °C
View Scheme
Multi-step reaction with 5 steps
1.1: thionyl chloride / dichloromethane; N,N-dimethyl-formamide / 1 h / Reflux
1.2: 1 h / 0 - 30 °C
2.1: sodium tetrahydroborate / tetrahydrofuran; water / 4 h / 30 °C
3.1: methanesulfonic acid / methanol / 3 h / 30 °C
4.1: s-butylmagnesium chloride; lithium chloride / toluene; tetrahydrofuran / 2 h / -5 - 0 °C
4.2: -45 - -35 °C
5.1: boron trifluoride diethyl etherate; triethylsilane / acetonitrile / 1 h / 30 - 42 °C
View Scheme
Hot Products
  • Display:default sort

    New supplier

  • Pharmaceutical Grade CAS 866607-35-4 with competitive price

  • Casno:

    866607-35-4

    Pharmaceutical Grade CAS 866607-35-4 with competitive price

    Min.Order: 1 Kilogram

    FOB Price:  USD $ 139.0-210.0

    WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

    Zhuo Zhou Wen Xi Import and Export Co., Ltd. is a company mainly engaged in the export of pharmaceutical raw materials. Its parent company is （Wen Xi Pharma）, including three subs

  •  Zhuozhou Wenxi import and Export Co., Ltd

     China (Mainland)  |  Contact Details

    Business Type:Trading Company

    Tel:+86-13111626072

    Address:Room 1710, Baoxin International Phase I, 19 Guanyun East Road, Zhuozhou, Hebei

       Inquiry Now

  • Canagliflozin Tetraacetate

  • Casno:

    866607-35-4

    Canagliflozin Tetraacetate

    Min.Order: 1 Kilogram

    FOB Price:  USD $ 1.0-1.0

    Name: Canagliflozin Tetraacetate Synonyms: (2R,3R,4R,5S,6S)-2-(acetoxymethyl)-6-(3-((5-(4-fluorophenyl)thiophen-2-yl)methyl)-4-methylphenyl)tetrahydro-2H-pyran-3,4,5-triyl triacetate; (3(R),4(R),5(S)-triacetoxy-6(S)-{3-[5-(4-fluoro-phenyl)-thiophen-

    Welcome to Henan Sinotech! Sinotech Corporation has exceptional sourcing ability for chemicals used in Organic Fine Chemicals and APIs; Inorganic chemicals; Flame Retardants;OLED

  •  Henan Sinotech Import&Export Corporation

     China (Mainland)  |  Contact Details

    Business Type:Other

    Tel:86-371-86181678

    Address:No. 260, Dongming Road,Jinshui District

       Inquiry Now

  • High Quality Canagliflozin Tetraacetate

  • Casno:

    866607-35-4

    High Quality Canagliflozin Tetraacetate

    Min.Order: 1 Kilogram

    FOB Price:  USD $ 0.0-0.0

    Product name: Canagliflozin Tetraacetate CAS No.： 866607-35-4 Molecule Formula：C32H33FO9S Molecule Weight：612.66 Purity: 99.0% Package: 25kg/drum Description：White crystalline powder Manufacture Standards：Enterprise Standard

    Siwei Development Group Ltd. is a reputed professional enterprise in China dedicated to the Amino Acids production and sales of fine chemical products.Over the years we have been m

  •  Siwei Development Group Ltd.

    China (Mainland)  |  Contact Details

    Business Type:Trading Company

    Tel:86-571-82881840

    Address:Rm2-2-503 Zhongdingyuan, Xianghurenjia Wenyan Xiaoshan, Hangzhou China

       Inquiry Now

  • Canagliflozin

  • Casno:

    866607-35-4

    Canagliflozin

    Min.Order: 0

    FOB Price:  USD $ 0.0-0.0

    made in GMP, commerially Application:Canagliflozin

    Shanghai SE Pharm Co., Ltd was headquartered in Shanghai Pudong new District. Our advantages are project analysis & integration and resources intergration according to the markets.

  •  Shanghai SE Pharm Co., Ltd

     China (Mainland)  |  Contact Details

    Business Type:Manufacturers

    Tel:0086-18616876482

    Address:Room 301, Building 1, Wuxing Road 707#, Pudong New district, Shanghai

       Inquiry Now

  • 866607-35-4

  • Casno:

    866607-35-4

    866607-35-4

    Min.Order: 0

    FOB Price:  USD $ 0.0-0.0

    Good Quality Package:1kg/bag Application:Medical or chemical Transportation:Air/Train/Sea Port:Shenzhen

    Shanghai Chinqesen Biotechnology Co., Ltd. Company slogan:Innovation, cooperation and win-win Company introduction:Shanghai Chinqesen Biotechnology Co., Ltd. is a professional phar

  •  Shanghai Chinqesen Biotechnology Co., Ltd.

    China (Mainland)  |  Contact Details

    Business Type:Trading Company

    Tel:+8617316470195

    Address:333 Songze Avenue, Qingpu District, Shanghai

       Inquiry Now

Post a RFQ

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

1

What can I do for you?
Get Best Price

Get Best Price for 866607-35-4