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| CAS No.: | 9004-07-3 |
|---|---|
| Name: | Chymotrypsin |
| Molecular Structure: | |
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| Formula: | N/A |
| Molecular Weight: | 0 |
| Synonyms: | Alphachymar;Alpha-chymar ophth;Avazyme;Benzyme;Catarase;Chymar;Chymotest;Chymotrypsin A;Chymotrypsin B;E.C. 3.4.21.1;E.C. 3.4.4.5;E.C.3.4.4.6;Enzeon;Quimar;Quimotrase;Zolyse;a-Chymostrypsin;a-Chymotrypsin;a-Chymotrypsin A;a1-Chymotrypsin;g-Chymotrypsin A; |
| EINECS: | 232-671-2 |
| Density: | 1.37[at 20℃] |
| Melting Point: | 127 ºC |
| Solubility: | 125g/L at 25℃ |
| Appearance: | White crystallized powder |
| Hazard Symbols: |
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| Risk Codes: | R36/37/38;R42 |
| Safety: | Poison by subcutaneous, intramuscular, intravenous and intraperitoneal routes. When heated to decomposition it emits toxic fumes of NOx. |
| PSA: | 0.00000 |
| LogP: | 0.00000 |
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Consensus Reports
Reported in EPA TSCA Inventory.
Specification
Chymotrypsin, with the CAS NO.9004-07-3, is a digestive enzyme belonging to a super family of enzymes called serine proteases. It has the Synonyms of alfapsin; alphachymar; alpha-chymarophth; alpha-chymotrypsinfrombovinepancreas; avazyme; catarase; chymar; chymolase. It uses an active serine residue to perform hydrolysis on the C-terminal of the aromatic amino acids of other proteins. Chymotrypsin is a protease enzyme that cleaves on the C-terminous phenylalanine (F), tryptophan (W), and tyrosine (Y) on peptide chains. It has specificty for aromatic amino acids because of its hydrophobic pocket.
When you are using this chemical, please be cautious about it as the following:
1. In case of contact with eyes, rinse immediately with plenty of water and seek medical advic;
2. Wear suitable protective clothing;
3. Wear suitable protective clothing and gloves;
4. Avoid contact with skin;
5. Do not breathe dust;
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| guinea pig | LDLo | intravenous | 50000units/kg (50000units/kg) | CARDIAC: OTHER CHANGES SENSE ORGANS AND SPECIAL SENSES: OTHER CHANGES: OLFACTION BLOOD: HEMORRHAGE | Archives Internationales de Pharmacodynamie et de Therapie. Vol. 106, Pg. 164, 1956. |
| mouse | LD50 | intramuscular | 104mg/kg (104mg/kg) | Drugs in Japan Vol. 6, Pg. 202, 1982. | |
| mouse | LD50 | intravenous | 89mg/kg (89mg/kg) | Drugs in Japan Vol. 6, Pg. 202, 1982. | |
| mouse | LD50 | oral | > 6gm/kg (6000mg/kg) | Drugs in Japan Vol. 6, Pg. 202, 1982. | |
| mouse | LD50 | subcutaneous | 185mg/kg (185mg/kg) | Drugs in Japan Vol. 6, Pg. 202, 1982. | |
| rabbit | LD50 | intravenous | 24000units/kg (24000units/kg) | GASTROINTESTINAL: OTHER CHANGES SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE" BLOOD: HEMORRHAGE | Archives Internationales de Pharmacodynamie et de Therapie. Vol. 106, Pg. 164, 1956. |
| rat | LD50 | intramuscular | 116mg/kg (116mg/kg) | Drugs in Japan Vol. 6, Pg. 202, 1982. | |
| rat | LD50 | intraperitoneal | 65100ug/kg (65.1mg/kg) | SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE" | Journal of the American Pharmaceutical Association, Scientific Edition. Vol. 39, Pg. 42, 1950. |
| rat | LD50 | intravenous | 84mg/kg (84mg/kg) | Drugs in Japan Vol. 6, Pg. 202, 1982. | |
| rat | LD50 | oral | > 4gm/kg (4000mg/kg) | Drugs in Japan Vol. 6, Pg. 202, 1982. | |
| rat | LD50 | subcutaneous | 250mg/kg (250mg/kg) | Drugs in Japan Vol. 6, Pg. 202, 1982. |