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Basic Information
| CAS No.: | 9009-65-8 |
|---|---|
| Name: | PROTAMINE SULFATE |
| Molecular Structure: | |
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|
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| Formula: | H2O4S |
| Molecular Weight: | 0 |
| Synonyms: | Protamine sulfates;Novoprotamine sulfate;Protamine sulfate; |
| EINECS: | 232-726-0 |
| Solubility: | H2O: 10 mg/mL |
| Appearance: | amorphous powder |
| Safety: | Poison by intraperitoneal, subcutaneous, and intravenous routes. Human systemic effects: anaphylaxis, blood pressure lowering, decreased urine volume or anuria. When heated to decomposition it emits very toxic fumes of NOx and SOx. |
| PSA: | 0.00000 |
| LogP: | 0.00000 |
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PROTAMINE SULFATE
Consensus Reports
Reported in EPA TSCA Inventory.
Specification
The Protamine sulfate, with the CAS registry number 9009-65-8, is also known as Sulfate de protamine. It belongs to the product categories of Organic matters.What's more,Its systematic name is Protamine sulfate.It is white amorphous powder.And it is used in gene transfer, protein purification and tissue cultures. It is also used to reverse the large dose of heparin administered during the heart surgery.It is hamfull to the health ,do not breathe dust and avoid contact with skin and eyes.
The toxicity data of Protamine sulfate as follows:
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| guinea pig | LD50 | intraperitoneal | 120mg/kg (120mg/kg) | Drugs in Japan Vol. 6, Pg. 726, 1982. | |
| guinea pig | LD50 | intravenous | 120mg/kg (120mg/kg) | Drugs in Japan Vol. 6, Pg. 726, 1982. | |
| guinea pig | LD50 | subcutaneous | 200mg/kg (200mg/kg) | Drugs in Japan Vol. 6, Pg. 726, 1982. | |
| man | LDLo | intravenous | 2174ug/kg/25M (2.174mg/kg) | VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION KIDNEY, URETER, AND BLADDER: URINE VOLUME DECREASED | Drug Intelligence and Clinical Pharmacy. Vol. 22, Pg. 211, 1988. |
| mouse | LD50 | intraperitoneal | 94mg/kg (94mg/kg) | Drugs in Japan Vol. 6, Pg. 726, 1982. | |
| mouse | LD50 | intravenous | 38mg/kg (38mg/kg) | Russian Pharmacology and Toxicology Vol. 38, Pg. 73, 1975. | |
| mouse | LD50 | subcutaneous | 200mg/kg (200mg/kg) | Drugs in Japan Vol. 6, Pg. 726, 1982. | |
| rabbit | LD50 | subcutaneous | 200mg/kg (200mg/kg) | Drugs in Japan Vol. 6, Pg. 726, 1982. | |
| rat | LD50 | intraperitoneal | 120mg/kg (120mg/kg) | Drugs in Japan Vol. 6, Pg. 726, 1982. | |
| rat | LD50 | intravenous | 75mg/kg (75mg/kg) | LUNGS, THORAX, OR RESPIRATION: DYSPNEA BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: CYANOSIS | Archives Internationales de Pharmacodynamie et de Therapie. Vol. 165, Pg. 374, 1967. |