Products Categories
Basic Information
| CAS No.: | 913611-97-9 |
|---|---|
| Name: | Brexpiprazole |
| Molecular Structure: | |
|
|
|
| Formula: | N/A |
| Molecular Weight: | 433.574 |
| Synonyms: | Brexpiprazole |
| Density: | 1.245±0.06 g/cm3(Predicted) |
| Melting Point: | 179 - 181oC |
| Boiling Point: | 675.2±55.0 °C(Predicted) |
Related products
- 958254-66-51H-Imidazo[4,5-b]pyridine-2-carboxaldehyde, 1-methyl-, hydrochloride
- 99170-93-1N-Methyl-2-oxazolamine
- 914458-26-7[5-(2-fluorophenyl)-1-pentyl-1H-pyrrol-3-yl]-1-naphthalenyl-Methanone
- 97730-31-9(S)-4'-(2-Methylbutyl)Biphenyl-4-Carbonitrile
- 926293-55-26-Bromo-2-methylpyridine-3-carboxaldehyde
- 95789-13-21,3,7-trimethylpurine-2,6-dione
- 956104-42-02-Bromo-5-nitro-3-(trifluoromethyl)pyridine
- 945683-37-41-butyl-2,3-dimethylimidazolium octanesulfate
- 946052-36-41-Butyl-3-methylpyridinium methanesulfonate
- 942196-38-51-Hexyl-3-methylpyridinium hexafluorophosphat
Synthetic route
- 913611-97-9
Brexpiprazole
Conditions
| Conditions | Yield |
|---|---|
| With sodium hydroxide In ethanol; water at 20 - 80℃; for 2h; | 96.1% |
- 913611-97-9
Brexpiprazole
Conditions
| Conditions | Yield |
|---|---|
| With potassium carbonate In dichloromethane; water for 2h; | 96% |
| Stage #1: 7-[4-(4-benzo[b]thiophen-4-yl-piperazin-1-yl)butoxy]-1H-quinolin-2-one hydrochloride In ethanol; water Reflux; Stage #2: With pyrographite In ethanol; water for 0.5h; Reflux; Stage #3: With sodium hydride In ethanol; water for 0.5h; Reflux; | 3.76 kg |
| With pyrographite In ethanol; water for 0.5h; Reflux; Large scale; | 3.76 kg |
- 913611-97-9
Brexpiprazole
Conditions
| Conditions | Yield |
|---|---|
| Stage #1: 1-(benzo[b]thiophen-4-yl)piperazine hydrochloride With sodium carbonate In methanol; water at 50℃; for 0.5h; Stage #2: 7-(4-chlorobutoxy)quinoline-2(1H)-one In methanol; water at 70℃; for 16h; | 95.5% |
| With potassium carbonate; potassium iodide In N,N-dimethyl-formamide at 70℃; for 10h; | 84% |
| With potassium carbonate In ethanol; water at 40 - 50℃; | 82.3% |
- 66490-33-3
4-chlorobenzothiophene
- 913611-97-9
Brexpiprazole
Conditions
| Conditions | Yield |
|---|---|
| With C48H55ClN2Pd; sodium t-butanolate In 1,2-dimethoxyethane at 20℃; for 16h; Inert atmosphere; Sealed tube; | 95% |
- 767-68-0
4-bromo-1,3-benzothiazole
- 913611-97-9
Brexpiprazole
Conditions
| Conditions | Yield |
|---|---|
| Stage #1: 4-bromobenzo[d]thiazole With isopropylmagnesium chloride In tetrahydrofuran at -5℃; for 2h; Stage #2: 7-(4-(piperazin-1-yl)butoxy)quinolin-2(1H)-one dihydrochloride In tetrahydrofuran for 3h; | 91.5% |
- 66490-33-3
4-chlorobenzothiophene
- 913611-97-9
Brexpiprazole
Conditions
| Conditions | Yield |
|---|---|
| With palladium diacetate; potassium carbonate; triphenylphosphine In 5,5-dimethyl-1,3-cyclohexadiene for 5h; Solvent; Reagent/catalyst; Inert atmosphere; Reflux; | 90% |
- 17402-83-4
benzo[B]thiophen-4-ylamine
- 913611-97-9
Brexpiprazole
Conditions
| Conditions | Yield |
|---|---|
| In butan-1-ol at 25 - 125℃; | 90% |
| With potassium carbonate; potassium iodide In 5,5-dimethyl-1,3-cyclohexadiene at 130 - 140℃; | 78.5% |
Conditions
| Conditions | Yield |
|---|---|
| With sodium carbonate In acetonitrile for 23h; Reflux; | 88.3% |
- 203395-59-9
7–(4-bromobutoxy)quinolin-2(1H)-one
- 913611-97-9
Brexpiprazole
Conditions
| Conditions | Yield |
|---|---|
| Stage #1: 1-(benzo[b]thiophen-4-yl)piperazine dihydrochloride With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 0.5h; Inert atmosphere; Stage #2: 7–(4-bromobutoxy)quinolin-2(1H)-one With potassium iodide In N,N-dimethyl-formamide at 100℃; for 4h; Inert atmosphere; | 85% |
- 177735-30-7
benzo[b]thiophen-4-ylboronic acid
- 913611-97-9
Brexpiprazole
Conditions
| Conditions | Yield |
|---|---|
| With copper diacetate; triethylamine In dichloromethane at 0 - 35℃; Reagent/catalyst; Solvent; Temperature; | 83.3% |
