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CAS No.: | 97483-77-7 |
---|---|
Name: | 5-Bromo-2-pyridinecarbonitrile |
Article Data: | 32 |
Molecular Structure: | |
Formula: | C6H3BrN2 |
Molecular Weight: | 183.007 |
Synonyms: | 2-Cyano-5-Bromopyridin;2-Cyano-5-Bromo pyridine;5-Bromo-2-cyanopyridine 97483-77-7;LDP05:5-Bromo-2-Cyanopyridine;5-bromopicolinonitrile;5-bromopyridine-2-carbonitrile;5-Bromo-2-cyanopyridine; |
EINECS: | -0 |
Density: | 1.72 g/cm3 |
Melting Point: | 128-132 °C(lit.) |
Boiling Point: | 260.3 °C at 760 mmHg |
Flash Point: | 111.2 °C |
Appearance: | light yellow cryst |
Hazard Symbols: | Xn,T,Xi |
Risk Codes: | 22-37/38-41-36/37/38-20/21/22 |
Safety: | 26-36/37/39-36/37-9 |
Transport Information: | UN 2811 6.1/PG 3 |
PSA: | 36.68000 |
LogP: | 1.71578 |
5-bromo-pyridine-2-carbaldehyde
2-Cyano-5-bromopyridine
Conditions | Yield |
---|---|
With ammonium hydroxide; iodine In tetrahydrofuran at 20℃; for 4h; | 100% |
With ammonia; iodine In tetrahydrofuran; water at 20℃; for 0.25h; | 85% |
3-bromopyridine N-oxide
trimethylsilyl cyanide
A
3-bromopyridine-2-carbonitrile
B
2-Cyano-5-bromopyridine
Conditions | Yield |
---|---|
With triethylamine In acetonitrile for 4h; Heating; | A 86% B 9% |
With triethylamine In acetonitrile for 4h; Product distribution / selectivity; Reflux; | |
With triethylamine In acetonitrile for 4h; Heating / reflux; |
Conditions | Yield |
---|---|
In sulfolane at 160℃; for 6h; Temperature; Solvent; | 83% |
In N,N-dimethyl-formamide at 150℃; for 7h; | 70% |
P-toluenesulfonyl cyanide
2-iodo-5-bromopyridine
2-Cyano-5-bromopyridine
Conditions | Yield |
---|---|
Stage #1: 2-iodo-5-bromopyridine With isopropylmagnesium chloride In tetrahydrofuran; dichloromethane at 0℃; for 0.75h; Stage #2: P-toluenesulfonyl cyanide In tetrahydrofuran; dichloromethane at 20℃; for 2h; | 82% |
Conditions | Yield |
---|---|
In N,N-dimethyl-formamide at 110 - 120℃; for 12h; | 74% |
With sodium cyanide In N,N-dimethyl-formamide for 3h; Heating; | 65% |
In 1-methyl-pyrrolidin-2-one at 110℃; for 20h; | 28% |
In 1-methyl-pyrrolidin-2-one at 110℃; for 20h; | 28% |
2,5-dibromopyridine
sodium cyanide
copper(I) cyanide
2-Cyano-5-bromopyridine
Conditions | Yield |
---|---|
In DMF (N,N-dimethyl-formamide) at 20 - 150℃; for 7h; | 70% |
Conditions | Yield |
---|---|
With sodium cyanide In N,N-dimethyl-formamide at 150℃; for 7h; Inert atmosphere; | 70% |
3-Bromopyridine
trimethylsilyl cyanide
A
3-bromopyridine-2-carbonitrile
B
3-bromo-4-cyanopyridine
C
2-Cyano-5-bromopyridine
Conditions | Yield |
---|---|
Stage #1: 3-Bromopyridine With trifluoromethylsulfonic anhydride In chloroform at 20℃; for 1h; Inert atmosphere; Sealed tube; Stage #2: trimethylsilyl cyanide In chloroform at 60℃; for 3h; Inert atmosphere; Sealed tube; Stage #3: With 4-methyl-morpholine In chloroform at 60℃; for 17h; Inert atmosphere; Sealed tube; Overall yield = 79 %; | A 13% B 55% C 11% |
Conditions | Yield |
---|---|
With copper(l) cyanide In N,N-dimethyl-formamide at 150℃; for 5h; | 53% |
2,5-dibromopyridine
sodium cyanide
copper(I) cyanide
2-Cyano-5-bromopyridine
Conditions | Yield |
---|---|
In N,N-dimethyl-formamide at 150℃; for 5h; | 53% |
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Molecular Formula: C6H3BrN2
Molecular Weight: 183.01 g/mol
Index of Refraction: 1.611
Density: 1.72 g/cm3
Flash Point: 111.2 °C
Enthalpy of Vaporization: 49.79 kJ/mol
Boiling Point: 260.3 °C at 760 mmHg
Vapour Pressure: 0.0124 mmHg at 25 °C
Melting point: 128-132 °C(lit.)
Appearance: Light yellow cryst
Structure of 5-Bromo-2-pyridinecarbonitrile (CAS NO.97483-77-7):
IUPAC Name: 5-Bromopyridine-2-carbonitrile
Product Category of 5-Bromo-2-pyridinecarbonitrile (CAS NO.97483-77-7): Bromides;Carboxes;Pyridine Series;Boron, Nitrile, Thio,& TM-Cpds;Heterocycles;Pyridines, Pyrimidines, Purines and Pteredines;Cyano;Organohalides;Heterocyclic Compounds;Heterocyclic Building Blocks
5-Bromo-2-pyridinecarbonitrile (CAS NO.97483-77-7) has been used for organic synthesis intermediate.
Hazard Symbols: Xn
Risk Statements:
22: Harmful if swallowed
41: Risk of serious damage to eyes
20/21/22: Harmful by inhalation, in contact with skin and if swallowed
36/37/38: Irritating to eyes, respiratory system and skin
37/38: Irritating to respiratory system and skin
Safety Statements information:
9: Keep container in a well-ventilated place
26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
36/37: Wear suitable protective clothing and gloves
36/37/39: Wear suitable protective clothing, gloves and
5-Bromo-2-pyridinecarbonitrile , its cas register number is 97483-77-7. It also can be called 5-Bromo-2-Cyanopyridine ; 5-bromopyridine-2-carbonitrile ; and 2-Pyridinecarbonitrile, 5-bromo- .