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| CAS No.: | 982-57-0 |
|---|---|
| Name: | Chloramphenicol sodium succinate |
| Molecular Structure: | |
|
|
|
| Formula: | C15H16Cl2N2O8.Na |
| Molecular Weight: | 445.18 |
| Synonyms: | Butanedioicacid, mono[(2R,3R)-2-[(dichloroacetyl)amino]-3-hydroxy-3-(4-nitrophenyl)propyl]ester, monosodium salt (9CI);Butanedioic acid,mono[2-[(dichloroacetyl)amino]-3-hydroxy-3-(4-nitrophenyl)propyl] ester,monosodium salt, [R-(R*,R*)]-;Succinic acid, a-monoester with D-threo-(-)-2,2-dichloro-N-[b-hydroxy-a-(hydroxymethyl)-p-nitrophenethyl]acetamide,monosodium salt (8CI);Betamicetin;Chloramphenicol monosuccinate sodium salt;Chloramphenicol succinate sodium;Clorofenicina;Cloromoin;Levomycetin-Nalcein;Mychel-S;Nalecin;Nevimycin;Protophenicol;Sodium chloramphenical monosuccinate;Solnicol; |
| EINECS: | 213-568-1 |
| Boiling Point: | 716.3oC at 760mmHg |
| Flash Point: | 387oC |
| Solubility: | Freely soluble in water |
| Appearance: | White powder |
| Hazard Symbols: |
 Xn
|
| Risk Codes: | 40 |
| Safety: | 22-36 |
| PSA: | 161.58000 |
| LogP: | 0.90410 |
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Chemistry
Chemistry informtion about Chloramphenicol Monosuccinate Sodium Salt (CAS NO.982-57-0) is:
Synonyms: Chloramphenicol Alpha-Succinate Sodium Salt ; Chloramphenicol Sodium Succinate ; Chloramphenicol Succinate Sodium ; Chloramphenicol Succinate Sodium Salt ; Alpha-Esterwithsodiumsuccinate ; Chloramphenicolmonosuccinatesodiumsalt ; Chloramphenicolsodiummonosuccinate ; Chloramphenicolsuccinatesodium*Minimum80%(Hpl
MF: C15H15Cl2N2NaO8
MW: 808.31
EINECS: 213-568-1
Following is the molecular structure of Chloramphenicol Monosuccinate Sodium Salt (CAS NO.982-57-0) is:
Uses
Chloramphenicol Monosuccinate Sodium Salt (CAS NO.982-57-0) can be used for anti-bacterial agent. Also used for parenteral administration of chloramphenicol.
Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| infant | LDLo | intravenous | 135mg/kg/3D-I (135mg/kg) | behavioral: somnolence (general depressed activity) behavioral: irritability lungs, thorax, or respiration: respiratory stimulation | Journal of Pediatrics. Vol. 103, Pg. 485, 1983. |
| mouse | LD50 | intravenous | 1530mg/kg (1530mg/kg) | Toxicology and Applied Pharmacology. Vol. 23, Pg. 537, 1972. | |
| rat | LD50 | intraperitoneal | 1400mg/kg (1400mg/kg) | Drugs in Japan Vol. 6, Pg. 248, 1982. | |
| rat | LD50 | intravenous | 1500mg/kg (1500mg/kg) | Drugs in Japan Vol. 6, Pg. 248, 1982. |
Safety Profile
Moderately toxic by intravenous and intraperitoneal routes. An experimental teratogen. Other experimental reproductive effects. Mutation data reported. When heated to decomposition it emits very toxic fumes of Cl−, Na2O, and NOx. See also other chloramphenicol entries.
Hazard Codes:
Xn
Risk Statements:
R40:Limited evidence of a carcinogenic effect.
Safety Statements:
S22:Do not breathe dust.
S36:Wear suitable protective clothing.
WGK Germany: 3
RTECS: AB6905000
Specification
Chloramphenicol Monosuccinate Sodium Salt (CAS NO.982-57-0) is a white powder. It is freely soluble in water. Flash point data for Chloramphenicol sodium succinate are not available, but Chloramphenicol sodium succinate is probably combustible.
First Aid Measures:
Ingestion: Do not induce vomiting. If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and immediately call a hospital or poison control center. Be prepared to transport the victim to a hospital if advised by a physician.
Inhalation: Immediately leave the contaminated area; take deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used.
Skin: Immediately flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment.
Eyes: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. Immediately transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.
Handling and Storage:
Storage: Keep in a cool, dry, dark location in a tightly sealed container or cylinder. Keep away from incompatible materials, ignition sources and untrained individuals. Secure and label area. Protect containers/cylinders from physical damage.
Handling: All chemicals should be considered hazardous. Avoid direct physical contact. Use appropriate, approved safety equipment. Untrained individuals should not handle this chemical or its container. Handling should occur in a chemical fume hood.