100558-20-1

• 

• Basic information

  1. Product Name: 1H-Imidazole, 2-(4-chlorophenyl)-4-phenyl-
  2. Synonyms:
  3. CAS NO:100558-20-1
  4. Molecular Formula: C15H11ClN2
  5. Molecular Weight: 254.719
  6. EINECS: N/A
  7. Product Categories: N/A
  8. Mol File: 100558-20-1.mol
  9. Article Data: 5

• Chemical Properties

  1. Melting Point: N/A
  2. Boiling Point: N/A
  3. Flash Point: N/A
  4. Appearance: N/A
  5. Density: N/A
  6. Refractive Index: N/A
  7. Storage Temp.: N/A
  8. Solubility: N/A
  9. CAS DataBase Reference: 1H-Imidazole, 2-(4-chlorophenyl)-4-phenyl-(CAS DataBase Reference)
  10. NIST Chemistry Reference: 1H-Imidazole, 2-(4-chlorophenyl)-4-phenyl-(100558-20-1)
  11. EPA Substance Registry System: 1H-Imidazole, 2-(4-chlorophenyl)-4-phenyl-(100558-20-1)

• Safety Data

  1. Hazard Codes: N/A
  2. Statements: N/A
  3. Safety Statements: N/A
  4. WGK Germany:
  5. RTECS:
  6. HazardClass: N/A
  7. PackingGroup: N/A
  8. Hazardous Substances Data: 100558-20-1(Hazardous Substances Data)

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• Usage
• SDS
• Upstream product
• Downstream Products
• Article

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100558-20-1 Usage

Imidazole derivative

A chemical compound derived from imidazole, which is a five-membered ring system containing two nitrogen atoms.

4-chlorophenyl substituent

A chlorine atom attached to a phenyl group (a six-membered carbon ring with alternating single and double bonds), which is attached to the imidazole ring at the 4-position (the meta position).

4-phenyl substituent

A phenyl group attached to the imidazole ring at the 4-position (the meta position).

Versatile building block

This compound is used as a starting material in organic synthesis for the preparation of various pharmaceuticals, agrochemicals, and other fine chemicals.

Biological activities

1H-Imidazole, 2-(4-chlorophenyl)-4-phenylexhibits a range of biological activities, including antifungal, antibacterial, and anticancer properties.

Ligand in coordination chemistry

This compound can bind to metal ions, forming coordination complexes, which are important in various chemical reactions and applications.

Reagent in the preparation of heterocyclic compounds

1H-Imidazole, 2-(4-chlorophenyl)-4-phenylis used as a reagent to synthesize compounds containing heteroatoms (atoms other than carbon and hydrogen) in their ring structures, such as other imidazole derivatives.

Applications and potential uses

This compound has various applications in the field of chemistry and pharmaceuticals, including the development of new drugs and chemical processes.

Check Digit Verification of cas no

The CAS Registry Mumber 100558-20-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,0,5,5 and 8 respectively; the second part has 2 digits, 2 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 100558-20:
(8*1)+(7*0)+(6*0)+(5*5)+(4*5)+(3*8)+(2*2)+(1*0)=81
81 % 10 = 1
So 100558-20-1 is a valid CAS Registry Number.

100558-20-1SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 16, 2017

Revision Date: Aug 16, 2017

1.Identification

1.1 GHS Product identifier

Product name	2-(4-chlorophenyl)-5-phenyl-1H-imidazole

1.2 Other means of identification

Product number	-
Other names	2-(4-chlorophenyl)-4(5)-phenylimidazole

1.3 Recommended use of the chemical and restrictions on use

Identified uses	For industry use only.
Uses advised against	no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number	-
Service hours	Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:100558-20-1 SDS

100558-20-1Upstream product

• 22198-19-2 4-chlorobenzoylaminoacetonitrile 
• 98-80-6 phenylboronic acid 
• 122-01-0 4-chloro-benzoyl chloride 
• 7257-94-5 1-phenyl-2-(p-tolylsulfonyloxy)ethanone 
• 19563-04-3 p-chlorobenzamidine 
• 1074-12-0 phenylglyoxal hydrate 
• 104-88-1 4-chlorobenzaldehyde 
• 82221-13-4 4-Chloro-N-[1-(2-oxo-2-phenylethyl)]benzamide 

100558-20-1Downstream Products

100558-20-1Relevant articles and documents

Nickel-Catalyzed Construction of 2,4-Disubstituted Imidazoles via C–C Coupling and C?N Condensation Cascade Reactions

Fang, Shengyang,Yu, Haihua,Yang, Xicheng,Li, Jianqi,Shao, Liming

, p. 3312 - 3317 (2019/06/13)

A convenient Ni(II)-catalyzed C?C and C?N cascade coupling reaction was developed to directly access various 2,4-disubstituted imidazoles. The reaction scope covers a variety of aryl and aliphatic substitutions, which demonstrate moderate-to-excellent yie

Anticonvulsant activity of 2,4(1H)-diarylimidazoles in mice and rats acute seizure models

Zuliani, Valentina,Fantini, Marco,Nigam, Aradhya,Stables, James P.,Patel, Manoj K.,Rivara, Mirko

experimental part, p. 7957 - 7965 (2011/01/13)

2,4(1H)-Diarylimidazoles have been previously shown to inhibit hNa V1.2 sodium (Na) channel currents. Since many of the clinically used anticonvulsants are known to inhibit Na channels as an important mechanism of their action, these compounds were tested in two acute rodent seizure models for anticonvulsant activity (MES and scMet) and for sedative and ataxic side effects. Compounds exhibiting antiepileptic activity were further tested to establish a dose response curve (ED50). The experimental data identified four compounds with anticonvulsant activity in the MES acute seizure rodent model (compound 10, ED50 = 61.7 mg/kg; compound 13, ED 50 = 46.8 mg/kg, compound 17, ED50 = 129.5 mg/kg and compound 20, ED50 = 136.7 mg/kg). Protective indexes (PI = TD 50/ED50) ranged from 2.1 (compound 10) to greater than 3.6 (compounds 13, 17 and 20). All four compounds were shown to inhibit hNa V1.2 in a dose dependant manner. Even if a correlation between sodium channel inhibition and anticonvulsant activity was unclear, these studies identify four Na channel antagonists with anticonvulsant activity, providing evidence that these derivatives could be potential drug candidates for development as safe, new and effective antiepileptic drugs (AEDs).

Syntheses of 2-aryl-4-(3-thienyl)imidazole derivatives with antiinflammatory properties

Suzuki,Maeda,Matsumoto,Ishizuka,Iwasawa

, p. 3111 - 3120 (2007/10/02)

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