100667-93-4Relevant articles and documents
Synthesis and cytotoxic activity of tetracenomycin d and of saintopin analogues
Martin, Philippe,Rodier, Stephane,Mondon, Martine,Renoux, Brigitte,Pfeiffer, Bruno,Renard, Pierre,Pierre, Alain,Gesson, Jean-Pierre
, p. 253 - 260 (2007/10/03)
Regiospecific synthesis of title compounds is based either on cycloaddition of ketene acetals derived from Hagemann's ester or of homophthalic anhydrides. Thus, tetracenomycin D and 3,8-di-O-methyl saintopin have been prepared in few steps. New derivatives of 10-deoxysaintorpin have been also obtained. Evaluation of their cytotoxicity against L1210 leukemia cells are reported. Copyright