10178-53-7Relevant articles and documents
Domino [Pd]-Catalysis: Heck followed by decarboxylative Sonogashira couplings under microwave irradiation in aqueous medium
Ramesh, Karu,Satyanarayana, Gedu
, p. 58 - 71 (2019)
A copper free [Pd]-catalyzed domino intramolecular Heck and intermolecular decarboxylative Sonogashira couplings, for the synthesis of alkyne bearing heterocyclic compounds with a quaternary carbon atom, is described. Notably, this dual bond forming strategy is successful in water solvent, under microwave irradiation. This one-pot operation enabled the formation of a variety of dihydrobenzofurans, indolines and oxindoles, in very good to near quantitative yields. Notably, unlike earlier reports, the present strategy is successful in delivering the products with short alkyl substituents on acetylene carbon, which is first of its kind.
HETEROCYCLIC COMPOUND
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, (2017/09/02)
Provided is a heterocyclic compound having a superior RBP4-lowering action and useful as a medicament for the prophylaxis or treatment of a disease or symptom mediated by an increase in RBP4 or retinol supplied by RBP4. A compound represented by the formula (I): wherein each symbol is as defined in the Description, or a salt thereof has a superior RBP4-lowering action, and is useful as a medicament for the prophylaxis or treatment of a disease or symptom mediated by an increase in RBP4 or retinol supplied by RBP4.
Palladium-catalyzed domino Mizoroki-Heck/intermolecular C(sp3)-H activation sequence: An approach to the formation of C(sp3)-C(sp3) bonds
Wang, Wei,Zhou, Rong,Jiang, Zhi-Jie,Wang, Xin,Fu, Hai-Yan,Zheng, Xue-Li,Chen, Hua,Li, Rui-Xiang
supporting information, p. 2579 - 2584 (2015/04/27)
A palladium-catalyzed domino Mizoroki-Heck/intermolecular unactivated C(sp3)-H alkylation reaction has been developed. This simple palladium nanoparticle catalytic system shows good activity and affords the dimeric dihydrobenzofuran derivatives
