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1143-50-6

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1143-50-6 Usage

Description

5H-DIBENZO(B,E)AZEPINE-6,11-DIONE is a yellow crystalline powder that belongs to the dibenzoazepine class of chemical compounds. It features a unique structure with two benzene rings fused to an azepine ring and possesses a ketone group at the 6th and 11th positions. 5H-DIBENZO(B,E)AZEPINE-6,11-DIONE is known for its pharmacological activities, such as anti-inflammatory and analgesic properties, and is studied for its potential therapeutic applications, particularly in the central nervous system.

Uses

Used in Pharmaceutical Industry:
5H-DIBENZO(B,E)AZEPINE-6,11-DIONE is used as an intermediate in the synthesis of various pharmaceuticals for its potential therapeutic applications. Its anti-inflammatory and analgesic properties make it a valuable component in the development of medications targeting pain and inflammation.
Used in Agrochemical Industry:
5H-DIBENZO(B,E)AZEPINE-6,11-DIONE is also utilized as an intermediate in the synthesis of agrochemicals, contributing to the development of products that can enhance crop protection and improve agricultural yields.
Used in Research and Medical Settings:
In research and medical settings, 5H-DIBENZO(B,E)AZEPINE-6,11-DIONE is studied for its effects on the central nervous system, exploring its potential in the treatment of neurological disorders and other related conditions. Its pharmacological activities are of interest to scientists and medical professionals seeking new approaches to address various health challenges.

Check Digit Verification of cas no

The CAS Registry Mumber 1143-50-6 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,1,4 and 3 respectively; the second part has 2 digits, 5 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 1143-50:
(6*1)+(5*1)+(4*4)+(3*3)+(2*5)+(1*0)=46
46 % 10 = 6
So 1143-50-6 is a valid CAS Registry Number.
InChI:InChI=1/C14H9NO2/c16-13-9-5-1-2-6-10(9)14(17)15-12-8-4-3-7-11(12)13/h1-8H,(H,15,17)

1143-50-6SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name 5H-benzo[c][1]benzazepine-6,11-dione

1.2 Other means of identification

Product number -
Other names 1,11-Dihydro-6H-dibenzo<b,e>azepin-6,11-dione

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:1143-50-6 SDS

1143-50-6Downstream Products

1143-50-6Relevant articles and documents

Visible-Light-Induced Cycloaddition of α-Ketoacylsilanes with Imines: Facile Access to β-Lactams

Ye, Jian-Heng,Bellotti, Peter,Paulisch, Tiffany O.,Daniliuc, Constantin G.,Glorius, Frank

supporting information, p. 13671 - 13676 (2021/05/11)

We report the synthesis of β-lactams from α-ketoacylsilanes and imines, which proceeds via a formal [2+2] photochemical cycloaddition with in situ generation of siloxyketene. This mild and operationally simple reaction proceeds in an atom-economic fashion with broad substrate scope, including aldimines, ketimines, hydrazones, and fused nitrogen heterocycles, affording a variety of important β-lactams with satisfactory diastereoselectivities in most cases. This reaction also features good functional-group tolerance, facile scalability and product diversification. Experimental and computational studies suggest that α-ketoacylsilanes can serve as photochemical precursors by engaging in a 1,3 silicon shift to the distal carbonyl group.

Mechanistic study of a complementary reaction system that easily affords quinazoline and perimidine derivatives

Wang, Zerong Daniel,Eilander, Joshua,Yoshida, Motoko,Wang, Tianzhi

supporting information, p. 7664 - 7674 (2015/04/22)

A new reaction between 2-aminobenzophenone and thiourea in dimethyl sulfoxide (DMSO) has been developed that primarily affords 4-phenylquinazoline as a single product. This reaction is also applicable, in general, to the reactions between thiourea and conformation-restricted β-amino ketones, such as 1-aminoanthracene-9,10-dione and 1-amino-9H-fluoren-9-one, to prepare perimidine derivatives. Experimental data is consistent with our computational study on the thermal decomposition of thiourea to form hydrogen sulfide and carbodiimide. This reaction involves a coupling between 2-aminobenzophenone and carbodiimide generated in situ from thiourea to form 4-phenylquinazolin-2(1H)-imine intermediate, and the generation of sulfur-containing reducing agent from hydrogen sulfide and DMSO, which reduces 4-phenylquinazolin-2(1H)-imine to 4-phenyl-1,2-dihydroquinazolin-2-amine. Elimination of ammonia from the latter yields 4-phenylquinazoline.

Application of the guanidine-acylguanidine bioisosteric approach to argininamide-type NPY Y2 receptor antagonists

Pluym, Nikola,Brennauer, Albert,Keller, Max,Ziemek, Ralf,Pop, Nathalie,Bernhardt, Guenther,Buschauer, Armin

scheme or table, p. 1727 - 1738 (2012/01/14)

Strongly basic groups such as guanidine moieties are crucial structural elements, but they compromise the drug-likeness of numerous biologically active compounds, including ligands of G-protein-coupled receptors (GPCRs). As part of a project focused on the search for guanidine bioisosteres, argininamide-type neuropeptideY (NPY) Y2 receptor (Y2R) antagonists related to BIIE0246 were synthesized. Starting from ornithine derivatives, NG-acylated argininamides were obtained by guanidinylation with tailor-made mono-Boc-protected N-acyl-S-methylisothioureas. The compounds were investigated for Y2R antagonism (calcium assays), Y2R affinity, and NPY receptor subtype selectivity (flow cytometric binding assays). Most of the NG-substituted (S)-argininamides showed Y2R antagonistic activities and binding affinities similar to those of the parent compound, whereas NG-acylated or -carbamoylated analogues with a terminal amine were superior (Y2R: Ki and KB values in the low nanomolar range). This demonstrates that the basicity of the compounds, although 4-5 orders of magnitude lower than that of guanidines, is sufficient to form key interactions with acidic amino acids of the Y2R. The acylguanidines bind with high affinity and selectivity to Y2R over the Y1, Y4, and Y5 receptors. As derivatization of the amino group is tolerated, these compounds can be considered building blocks for the preparation of versatile fluorescent and radiolabeled pharmacological tools for invitro studies of the Y2R. The results support the concept of bioisosteric guanidine-acylguanidine exchange as a broadly applicable approach to retain pharmacological activity despite decreased basicity.

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