1150-31-8Relevant articles and documents
ROMP-generated oligomeric sulfonyl chlorides as versatile soluble scavenging agents.
Moore, Joel D,Herpel, Russell H,Lichtsinn, Joy R,Flynn, Daniel L,Hanson, Paul R
, p. 105 - 107 (2003)
[reaction: see text] A new method for homogeneous nucleophilic scavenging employing oligomeric sulfonyl chloride (OSC) reagents is described. The method utilizes OSC to rapidly scavenge a variety of amines that are present in excess. The OSC reagents are generated from ROM polymerization of 2-chlorosulfonyl-5-norbornene utilizing the second generation Grubbs catalyst to produce oligomers of varying size as stable, free-flowing powders. Following the scavenging event, these oligomers are precipitated with ethyl acetate leaving products in excellent yield and purity.
A general method for site-selective Csp3-S bond formation: Via cooperative catalysis
Qin, Yuman,Han, Yujie,Tang, Yongzhen,Wei, Junfa,Yang, Mingyu
, p. 1276 - 1282 (2020)
Herein, we report a copper-catalysed site-selective thiolation of Csp3-H bonds of aliphatic amines. The method features a broad substrate scope and good functional group compatibility. Primary, secondary, and tertiary C-H bonds can be converted into C-S bonds with a high efficiency. The late-stage modification of biologically active compounds by this method was also demonstrated. Furthermore, the one-pot preparation of pyrrolidine or piperidine compounds via a domino process was achieved.
Aqueous MW eco-friendly protocol for amino group protection
Nardi,Cano, N. Herrera,Costanzo,Oliverio,Sindona,Procopio
, p. 18751 - 18760 (2015/06/15)
In this paper a new catalyst-free and on-water method for protection of amines and amino acids with di-tert-butyl dicarbonate, 9-fluorenylmethoxycarbonyl chloride, acetyl chloride and tosyl chloride is presented. The protection can be realized in a few minutes under microwave-assistance. The reaction proved to be chemoselective in presence of ambident nucleophiles and water solution of di-tert-butyl carboxylic acid or chloride acid are the only wastes produced.