118578-06-6Relevant articles and documents
Different Acyl Specificity between Mold and Kidney Acylases: Correlation of Hydrolytic Rate to Molecular Size and Electronegative Property of Acyl Group in Acyl-L-phenylalanine Hydrolysis
Kang, Shinwon,Minematsu, Yoshihiro,Shimohigashi, Yasuyuki,Waki, Michinori,Izumiya, Nobuo
, p. 575 - 576 (1988)
A series of acyl-L-phenylalanines were hydrolyzed by mold and hog kidney acylases.The formyl was found to be the most susceptible for mold acylase, and the butyryl for kidney acylase, indicating the different preferences of these acylases in molecular size and electronegative property of acyl group of substrates.
CARBON MONOXIDE RELEASING NORBORNENONE COMPOUNDS
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Page/Page column 56; 144, (2017/09/27)
The present invention provides organic compounds which are capable of releasing carbon monoxide under physiological conditions or pH trigger, and to the use of such compounds for conditioning a cell, tissue or organ, for example, to protect against ischaemic injury during a transplant event.
Studies on the synthesis of peptides containing dehydrovaline and dehydroisoleucine based on copper-mediated enamide formation
Gille, Franziska,Kirschning, Andreas
supporting information, p. 564 - 570 (2016/04/08)
The preparation of peptide fragments containing dehydrovaline and dehydroisoleucine moieties present in the antibiotic myxovalargin is reported. Peptide formation is based on a copper-mediated C-N cross-coupling protocol between an acyl amide and a peptidic vinyl iodide. The presence of a neighboring arginine in the vinyl iodide posed a challenge with respect to the choice of the protecting group and the reaction conditions. It was found that ornithine - a suitable precursor - is better suited than arginine for achieving good yields for the C-N cross-coupling reaction. The optimized conditions were utilized for the synthesis of peptides 32, 33, 39 and 40 containing a neighboring ornithine as well as for the tripeptide 44 containing dehydroisoleucine with the correct stereochemistry.
Decomposition of copper-amino acid complexes by oxalic acid dihydrate
Liu, Yi,Jia, Genguang,Ling, Xin,Lan, Nuo,Zheng, Youguang,Li, Sai,Zhang, Ling,Liu, Ling,Zhang, Rongli,Xue, Yunsheng
experimental part, p. 557 - 559 (2012/08/08)
A facile approach to the synthesis of some side-chain-protected amino acids via oxalic acid dihydrate as the copper sequestering reagent is presented. The copper in the amino acid complex reacted with oxalic acid dihydrate to form insoluble cupric oxalate, with the free amino acid released. Compared with conventional methods, this method is convenient, inexpensive, and environmentally friendly.
