124915-24-8Relevant articles and documents
A Novel, One-Pot Ring Expansion of Cyclobutanones. Syntheses of Carbovir and Aristeromycin
Brown, Brian,Hegedus, Louis S.
, p. 1865 - 1872 (2007/10/03)
A novel, one-pot ring-expansion procedure was developed using Me3S(O)I, NaH, and Sc(OTf)3. The scope and limitations were briefly examined, and a tentative mechanism was proposed. Application of the methodology to known cyclobutanone 1 provided the corresponding cyclopentanone, which was successfully advanced to (+)-carbovir and (+)-aristeromycin.
Practical enantiodivergent syntheses of both enantiomers of carbovir, 1592U89 and six-membered ring analogues
Olivo, Horacio F.,Yu, Jiaxin
, p. 391 - 392 (2007/10/03)
The hydroxylactones 4a-b (both available in optically pure form from biocatalytic processes) have been used in the preparation of carbovir, 1592U89, and their six-membered ring analogues.
Palladium-catalyzed Chemoselective Reaction of Allylic Carbonate with Nucleoside Bases and Its Application for the Synthesis of Carbocyclic Nucleosides. (-)- and (+)-Carbovirs
Nokami, Junzo,Matsuura, Hiroyuki,Nakasima, Koichi,Shibata, Satoshi
, p. 1071 - 1074 (2007/10/02)
Palladium(0)-catalyzed reaction of 2-cyclopenten-1-yl methyl carbonate derivatives with nucleoside bases gave carbocyclic nucleosides chemo- and regioselectively under the neutral reaction conditions.The reaction was effectively used for the synthesis of
