132722-90-8Relevant articles and documents
Enhanced Brain Delivery of an Anti-HIV Nucleoside 2'-F-ara-ddI by Xanthine Oxidase Mediated Biotransformation
Shanmuganathan, Kirupa,Koudriakova, Tatiana,Nampalli, Satyanarayana,Du, Jinfa,Gallo, James M.,et al.
, p. 821 - 827 (2007/10/02)
In order to enhance the brain delivery of 2'-F-ara-ddI, 2'-F-ara-ddP 6 was synthesized and its in vitro and in vivo bioconversion reaction studied.For the study, a new efficient synthetic method for 2'-F-ara-ddP 6 was developed from 5-benzoyl-1,2-O-isopro
Potential Anti-AIDS Drugs. Lipophilic, Adenosine Deaminase-Activated Prodrugs
Barchi, Joseph J.,Marquez, Victor E.,Driscoll, John S.,Ford, Harry,Mitsuya, Hiroaki,et al.
, p. 1647 - 1655 (2007/10/02)
Selected acid-stable (2'-fluoro-2',3'-dideoxyarabinofuranosyl)adenine nucleosides containing methyl groups and other lipophilic functions at various positions in the adenine ring were prepared and evaluated as anti-HIV agents.The N6-methyl (1f)