140927-13-5 Usage
Description
Benzyl 5-oxo-2aza-bicyclo[2.2.1]heptance-2-carboxylate is a chemical compound that serves as an intermediate in the synthesis of potent agonists of nicotinic acetylcholine receptors. It is characterized by its unique molecular structure and plays a crucial role in the development of pharmaceuticals targeting these receptors.
Uses
Used in Pharmaceutical Industry:
Benzyl 5-oxo-2aza-bicyclo[2.2.1]heptance-2-carboxylate is used as a key intermediate in the synthesis of potent agonists for nicotinic acetylcholine receptors. Its application is significant in the development of drugs that can modulate these receptors, which are involved in various physiological processes and are potential targets for the treatment of neurological and neuromuscular disorders.
Used in Research and Development:
In addition to its role in the pharmaceutical industry, benzyl 5-oxo-2aza-bicyclo[2.2.1]heptance-2-carboxylate is also utilized in research and development for the study of nicotinic acetylcholine receptors and their role in various diseases. benzyl 5-oxo-2aza-bicyclo[2.2.1]heptance-2-carboxylate can help researchers understand the receptor's structure, function, and potential therapeutic applications, ultimately contributing to the advancement of medical knowledge and the development of novel treatments.
Check Digit Verification of cas no
The CAS Registry Mumber 140927-13-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,0,9,2 and 7 respectively; the second part has 2 digits, 1 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 140927-13:
(8*1)+(7*4)+(6*0)+(5*9)+(4*2)+(3*7)+(2*1)+(1*3)=115
115 % 10 = 5
So 140927-13-5 is a valid CAS Registry Number.
InChI:InChI=1/C14H15NO3/c16-13-7-12-6-11(13)8-15(12)14(17)18-9-10-4-2-1-3-5-10/h1-5,11-12H,6-9H2
140927-13-5Relevant articles and documents
Histamine H3 Inverse Agonists and Antagonists and Methods of Use Thereof
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Page/Page column 66, (2011/04/18)
Provided herein are fused imidazolyl compounds, methods of synthesis, and methods of use thereof. The compounds provided herein are useful for the treatment, prevention, and/or management of various disorders, including, e.g., neurological disorders and metabolic disorders. Compounds provided herein inhibit the activity of histamine H3 receptors and modulate the release of various neurotransmitters, such as, e.g., histamine, acetylcholine, norepinephrine, and dopamine (e.g. at the synapse). Pharmaceutical compositions containing the compounds and their methods of use are also provided herein.
Synthesis and Muscarinic Receptor Activity of Ester Derivatives of 2-Substituted 2-Azabicycloheptan-5-ol and -6-ol
Carroll, F. Ivy,Abraham, Phillip,Chemburkar, Sanjay,He, Xu-Chang,Mascarella, S. Wayne,et al.
, p. 2184 - 2191 (2007/10/02)
Radioligand binding affinities of four new muscarinic antagonists and six potential muscarinic agonists which possess the 2-alkyl-2-azabicycloheptane ring system have been determined in rat heart, rat brain, and m1- or m3-tran