146144-48-1 Usage
General Description
(3R)-3-[[2-[(3R)-2-oxo-3-[2-(4-piperidyl)ethyl]-1-piperidyl]acetyl]amino]butanoic acid, also known as L-659,699, is a synthetic chemical compound with potential pharmaceutical applications. It is a derivative of the neurotransmitter gamma-aminobutyric acid (GABA) and acts as a selective GABA-B antagonist. (3R)-3-[[2-[(3R)-2-oxo-3-[2-(4-piperidyl)ethyl]-1-piperidyl]acetyl]amino]butanoic acid has been studied for its potential use in treating mood disorders, schizophrenia, and other conditions related to GABA transmission in the central nervous system. Its structure and pharmacological properties make it a subject of interest for research in the field of neuropharmacology.
Check Digit Verification of cas no
The CAS Registry Mumber 146144-48-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,6,1,4 and 4 respectively; the second part has 2 digits, 4 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 146144-48:
(8*1)+(7*4)+(6*6)+(5*1)+(4*4)+(3*4)+(2*4)+(1*8)=121
121 % 10 = 1
So 146144-48-1 is a valid CAS Registry Number.
InChI:InChI=1/C18H31N3O4/c1-13(11-17(23)24)20-16(22)12-21-10-2-3-15(18(21)25)5-4-14-6-8-19-9-7-14/h13-15,19H,2-12H2,1H3,(H,20,22)(H,23,24)/t13-,15+/m1/s1
146144-48-1Relevant articles and documents
Non-Peptide Fibrinogen Receptor Antagonists. 7. Design and Synthesis of a Potent, Orally Active Fibrinogen Receptor Antagonist
Duggan, Mark E.,Naylor-Olsen, Adel M.,Perkins, James J.,Anderson, Paul S.,Chang, Charles T.-C.,et al.
, p. 3332 - 3341 (1995)
The design, synthesis, and pharmacological evaluation of L-734,217, a potent, low-molecular weight, orally active fibrinogen receptor antagonist, is reported.A strategy for producing low-molecular weight inhibitors from the peptide c-A, previou
Asymmetric hydrogenation of 3-alkylidene-2-piperidones using Noyori's catalyst. Effect of N-substituents on the enantioselectivity
Chung, John Y. L.,Zhao, Dalian,Hughes, David L.,McNamara, James M.,Grabowski, Edward J. J.,Reider, Paul J.
, p. 7379 - 7382 (2007/10/02)
The enantioselectivity in the asymmetric hydrogenation of 3-alkylidene-2-piperidones catalyzed by BINAP-Ru(II) complex was found to be significantly effected by the internal substituents on the lactam nitrogen, affording the corresponding 3-alkyl-2-piperidones in 52-92% ee.
