16860-43-8Relevant articles and documents
A dinuclear palladium catalyst for α-Hydroxylation of carbonyls with O2
Chuang, Gary Jing,Wang, Weike,Lee, Eunsung,Ritter, Tobias
supporting information; scheme or table, p. 1760 - 1762 (2011/04/15)
A chemo- and regioselective α-hydroxylation reaction of carbonyl compounds with molecular oxygen as oxidant is reported. The hydroxylation reaction is catalyzed by a dinuclear Pd(II) complex, which functions as an oxygen transfer catalyst, reminiscent of an oxygenase. The development of this oxidation reaction was inspired by discovery and mechanism evaluation of previously unknown Pd(III)-Pd(III) complexes.
Improvement of a biomimetic porphyrin catalytic system by addition of acids.
Segrestaa, Jerome,Verite, Philippe,Estour, Francois,Menager, Sabine,Lafont, Olivier
, p. 744 - 748 (2007/10/03)
The conditions of the use of the manganese/porphyrin/imidazole system needed to be improved in order to obtain larger amounts of models of metabolites. An increase of the oxidation yields and a better preservation of this catalytic system have been obtained on the examples of various alkanes, by an acid addition in the reaction mixture. Three manganoporphyrins were checked for evaluation of the reaction. These results were extended to molecules of therapeutical interest such as ibuprofen and phenylbutazone.
Chemical synthesis of phenylbutazone hydroperoxide and investigation of the drug for cardiac action under in vitro and in vivo conditions
Mentz,Schulz,Kluge
, p. 1229 - 1232 (2007/10/02)
Phenylbutazone (4-n-butyl-1,2-diphenyl-pyrazolidine-3,5-dione) 1 is an easily autoxidable substance which forms a crystalline and stable hydroperoxide 3. The decomposition of 3 yields products which were investigated as metabolites of the drug. In isolate
