19499-19-5Relevant articles and documents
COMPOUNDS FOR THE DEGRADATION OF BRD9 OR MTH1
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Page/Page column 267; 274-275, (2020/03/29)
Compounds that degrade BRD9 or MTH1 via the ubiquitin proteasome pathway in a subject in need thereof for therapeutic applications are provided. The compounds provided have an E3 Ubiquitin Ligase targeting moiety (Degron) that is linked to a Targeting Ligand for BRD9 or MTH1.
A four-ring quinolinone alkaloid derivative and its preparation method and application (by machine translation)
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Paragraph 0142; 0177, (2018/10/27)
The invention relates to a four-ring quinolinone alkaloid derivative, or a tautomer thereof, stereo isomer, racemate, enantiomer of non-isometric mixture, geometric isomer, solvate, pharmaceutically acceptable salt or prodrug, and pharmaceutical composition containing the compound. The invention also discloses such compounds and pharmaceutical compositions thereof as a medicament, in particular as anti-virus, antibacterial and the anti-parasitic drug use. (by machine translation)
New 1,8-naphthyridine and quinoline derivatives as CB2 selective agonists
Manera, Clementina,Cascio, Maria Grazia,Benetti, Veronica,Allara, Marco,Tuccinardi, Tiziano,Martinelli, Adriano,Saccomanni, Giuseppe,Vivoli, Elisa,Ghelardini, Carla,Di Marzo, Vincenzo,Ferrarini, Pier Luigi
, p. 6505 - 6510 (2008/09/20)
A series of new 1,8-naphthyridine and quinoline derivatives were synthesized and evaluated for their cannabinoid receptor affinity. In particular, compounds 2, 5, 11, and 13 showed a high CB2 affinity and CB2 versus CB1 selectivity, in agreement with molecular modeling studies. Furthermore, compound 2 also exhibited in vivo antinociceptive effects.
