195257-62-6Relevant articles and documents
Synthesis of cyclic alkenylsiloxanes by semihydrogenation: A stereospecific route to (Z)-alkenyl polyenes
Elbert, Bryony L.,Lim, Diane S. W.,Gudmundsson, Haraldur G.,O'Hanlon, Jack A.,Anderson, Edward A.
, p. 8594 - 8598 (2014/07/21)
Cyclic alkenylsiloxanes were synthesized by semihydrogenation of alkynylsilanes - a reaction previously plagued by poor stereoselectivity. The silanes, which can be synthesized on multigram scale, undergo Hiyama-Denmark coupling to give (Z)-alkenyl polyene motifs found in bioactive natural products. The ring size of the silane is crucial: five-membered cyclic siloxanes also couple under fluoride-free conditions, whilst their six-membered homologues do not, enabling orthogonality within this structural motif.
Rugulactone derivatives act as inhibitors of NF-κB activation and modulates the transcription of NF-κB dependent genes in MDA-MB-231cells
Mohapatra, Debendra K.,Reddy, D. Sai,Janaki Ramaiah,Ghosh, Sowjanya,Pothula, Vikram,Lunavath, Swetha,Thomas, Shine,Pushpa Valli,Bhadra, Manika Pal,Yadav, Jhillu S.
, p. 1389 - 1396 (2014/03/21)
Rugulactone and its analogues were synthesized following Horners-Wadsworth-Emmons and ring-closing metathesis as the key reactions. A library of new rugulactone analogues were designed, synthesized and evaluated for their anticancer activity in breast can
Total synthesis and revision of the absolute configuration of seimatopolide B
Reddy, Chada Raji,Dilipkumar, Uredi,Reddy, Motatipally Damoder,Rao, Nagavaram Narsimha
, p. 3355 - 3364 (2013/06/05)
The asymmetric total synthesis of natural seimatopolide B along with its enantiomer is described starting from readily available 5-hexen-1-ol and 3-buten-1-ol. The key steps involved are Jacobson hydrolytic kinetic resolution, proline-catalyzed α-hydroxyl