195375-68-9Relevant articles and documents
Synthesis of protected 3'-amino nucleoside monomers
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Page/Page column 8; sheet 5, (2008/06/13)
Orthogonally protected 3′-amino nucleoside monomers and efficient methods for their synthesis are described. The methods employ selective protection of the 3′-amino group in the presence of the unprotected nucleoside base.
A new approach to oligonucleotide N3′-→P5′ phosphoramidate building blocks
Zielinska, Daria,Pongracz, Krisztina,Gryaznov, Sergei
, p. 1063 - 1067 (2007/10/03)
A new synthetic approach to 5′-phosphoramidites of 3′-aminonucleosides was developed. The methodology relies upon the use of 3′-amino-2′,3′-dideoxy nucleosides as the key starting materials. The final phosphoramidite products were obtained with high yields via 2-3-step efficient chemical transformations using selective introduction of orthogonal protective groups to the 3′-aminonucleoside sugar and base moieties. Copyright Taylor & Francis, Inc.