19543-85-2Relevant articles and documents
Pure organic room-temperature phosphorescent material based on thiochromanone derivative as well as preparation method and application of pure organic room-temperature phosphorescent material
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Paragraph 0040; 0044-0046, (2021/04/21)
The embodiment of the invention discloses a pure organic room-temperature phosphorescent material based on a thiochromanone derivative as well as a preparation method and application of the pure organic room-temperature phosphorescent material. The organi
Synthesis and anti cervical cancer activity of novel 5H-thiochromeno [4,3-d]pyrimidines
Naliapara, Yogesh,Pandya, Dhananjay
, p. 294 - 302 (2020/04/21)
A series of novel 5H-Thiochromeno[4,3-d]pyrimidine derivatives were synthesized, purified and characterized by different spectroscopy techniques such as1H NMR,13C NMR, Mass and Elemental Analysis. The new compounds were evaluated for their anti-cervical cancer activity on Human Cervical Cell Line HeLa. They were found to be potent anti-cervical cancer agents with GI50 values less than 10 μg/mL with respect to positive control drug Adriamycin.
Hydrazone derivatives enhance antileishmanial activity of thiochroman-4-ones
Vargas, Esteban,Echeverri, Fernando,Upegui, Yulieth A.,Robledo, Sara M.,Qui?ones, Wiston
, (2018/01/12)
Cutaneous leishmaniasis (CL) is a neglected tropical disease, which causes severe skin lesions. Due to the lack of effective vaccines, and toxicity or reduced effectiveness of available drugs in addition to complex and prolonged treatments, there is an urgent need to develop alternatives for the treatment for CL with different mechanisms of action. In our effort to search for new promising hits against Leishmania parasites we prepared 18 acyl hydrazone derivatives of thiochroman-4-ones. Compounds were evaluated for their in vitro antileishmanial activity against the intracellular amastigote form of Leishmania panamensis and cytotoxic activity against human monocytes (U-937 ATCC CRL-1593.2). Our results show that derivatization of the thiochroman-4-ones with acyl hydrazones significantly enhances the antileishmanial activity. Among the compounds tested semicarbazone and thiosemicarbazone derivatives of thioflavanone 19 and 20 displayed the highest antileishmanial activities, with EC50 values of 5.4 and 5.1 μM and low cytotoxicities (100.2 and 50.1 μM respectively), resulting in higher indexes of selectivity (IS).
