19686-79-4Relevant articles and documents
A novel synthesis of 4-cycloheptenones
Marvell, Elliot N.,Titterington, Donald
, p. 2123 - 2124 (1980)
4-Cycloheptenones, mono and bicyclic, can be prepared by a base catalyzed thermal reaction of 1-hepten-6-yn-3-ols.
Enantioselective Synthesis of Tropanes: Br?nsted Acid Catalyzed Pseudotransannular Desymmetrization
Carrillo, Luisa,Merino, Pedro,Reyes, Efraim,Rodriguez, Sandra,Tejero, Tomás,Uria, Uxue,Vicario, Jose L.
supporting information, p. 6780 - 6784 (2020/03/19)
The enantioselective synthesis of tropanols has been accomplished through chiral phosphoric acid catalyzed pseudotransannular ring opening of 1-aminocyclohept-4-ene-derived epoxides. The reaction proceeds together with the desymmetrization of the starting
At Long Last: Olefin Metathesis Macrocyclization at High Concentration
Sytniczuk, Adrian,Dabrowski, Micha?,Banach, ?ukasz,Urban, Mateusz,Czarnocka-?niada?a, Sylwia,Milewski, Mariusz,Kajetanowicz, Anna,Grela, Karol
supporting information, p. 8895 - 8901 (2018/07/05)
Macrocyclic lactones, ketones, and ethers can be obtained in the High-Concentration Ring-Closing Metathesis (HC-RCM) reaction in high yield and selectivity at concentrations 40 to 380 times higher than those typically used by organic chemists for similar macrocyclizations. The new method consists of using tailored ruthenium catalysts together with applying vacuum to distill off the macrocyclic product as it is formed by the metathetical backbiting of oligomers. Unlike classical RCM, no large quantities of organic solvents are used, but rather inexpensive nonvolatile diluents, such as natural or synthetic paraffin oils. Moreover, use of a protecting atmosphere or a glovebox is not needed, as the new catalysts are perfectly moisture and air stable. In addition, some other cyclic compounds previously reported as unobtainable by RCM in neat conditions, or in high dilutions even, can be formed with the help of the HC-RCM method.
TRANS-CYCLOHEPTENES AND HETERO-TRANS-CYCLOHEPTENES FOR BIOORTHOGONAL COUPLING
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Page/Page column 11, (2017/04/29)
A substituted trans-cycloheptene according to formula (I); wherein : a) Z and L are each selected from the group consisting of SiR1R2, CH2, CHOH, and CHR2; R1 is phenyl or CH3; R2 is phenyl, CH3, (CH2)nCN, or (CH2)nOH, wherein n is an integer from 1 to 5; Ra and Rb are each individually selected from the group consisting of H, OH, and CH3; and Z and L are not both SiR1R2; or b) Z is BocN, L is CH2, Ra is H, and Rb is H; or c) Z is C=0, L is CH2, Ra is H, and Rb is H.
