19932-26-4Relevant articles and documents
Synthesis and characterization of a novel fluorinated polyether glycol with fluorinated side chains via "living/controlled" cationic polymerization
Li, Lingling,Li, Ying,Wang, Xia,Qi, Yuanchun,Hu, Jiaojiao,Fang, Zhou,Dong, Qingzhi
, p. 129 - 138 (2015)
A novel fluorinated polyether glycol with fluorinated side chains is synthesized via "living/controlled" cationic ring-opening polymerization of tetrahydrofuran and fluorine-containing epoxy compounds (FO). The effects of polymerization conditions on monomer conversion, number-average molecular weight (Mn), molecular weight distribution (Mw/Mn) are measured. Our investigations have shown that the use of a mixed solvent (dichloromethane/1,4-dioxane) can prevent intra- and intermolecular transfer reactions, due to more nucleophilic oxygen atom in 1,4-dioxane. Using BF3·CH3OH/CH2OHCH2OH as initiation system, polymers with predictable number-average molecular weight, narrow molecular weight distribution (1.03 w/Mn 1.08) were produced. On the basis of the reactivity ratio of FO/THF and monomer conversion, a mechanism of living/controlled polymerization has been proposed.
The synthesis and curing kinetics study of a new fluorinated polyurethane with fluorinated side chains attached to soft blocks
Li, Lingling,Wang, Xia,Li, Zan,Bi, Wei,Li, Ying,Qi, Yuanchun,Dong, Qingzhi
, p. 596 - 605 (2016)
Fluorinated polyurethane (FPU) with fluorine in the side chain was obtained using fluorinated polyether glycol (FPO) with fluorinated side chains and 4,4′-diphenyl methane diisocyanate (MDI). The direct visual inspection of microstructures by SEM revealed that the separation degree of soft and hard segments decreased with the introduction of fluorinated groups into polyurethane soft segments, leading to a decrease in the crystallinity of FPU. The glass transition temperatures (Tg) measured by DMA indicated that the optimal working temperature window of FPU separating soft and hard glass transitions became narrow. And the mechanical properties and surface properties of the FPU were also measured. Curing kinetics of FPU was studied using a rotational rheometer, and the activation energy of FPU was obtained. The relationship between the curing temperature and the mobility of fluorinated groups was characterized by XPS. The result showed that F content in the FPU surface decreased with increasing curing temperature.
Rational design 2-hydroxypropylphosphonium salts as cancer cell mitochondria-targeted vectors: Synthesis, structure, and biological properties
Amerhanova, Syumbelya K.,Dimukhametov, Mudaris N.,Gubaidullin, Aidar T.,Islamov, Daut R.,Litvinov, Igor A.,Lyubina, Anna P.,Mironov, Vladimir F.,Nemtarev, Andrey V.,Pashirova, Tatiana N.,Titov, Eugenii A.,Tsepaeva, Olga V.,Voloshina, Alexandra D.
, (2021/11/01)
It has been shown for a wide range of epoxy compounds that their interaction with triphenylphosphonium triflate occurs with a high chemoselectivity and leads to the formation of (2-hydroxypropyl)triphenylphosphonium triflates 3 substituted in the 3-position with an alkoxy, alkylcarboxyl group, or halogen, which were isolated in a high yield. Using the methodology for the disclosure of epichlorohydrin with alcohols in the presence of boron trifluoride ether-ate, followed by the substitution of iodine for chlorine and treatment with triphenylphosphine, 2-hydroxypropyltriphenylphosphonium iodides 4 were also obtained. The molecular and supramolec-ular structure of the obtained phosphonium salts was established, and their high antitumor activity was revealed in relation to duodenal adenocarcinoma. The formation of liposomal systems based on phosphonium salt 3 and L-α-phosphatidylcholine (PC) was employed for improving the bioavailabil-ity and reducing the toxicity. They were produced by the thin film rehydration method and exhibited cytotoxic properties. This rational design of phosphonium salts 3 and 4 has promising potential of new vectors for targeted delivery into mitochondria of tumor cells.
