10007-36-0

Upstream product

• 1882-86-6 11-Keto-16-dehydroprogesterone 
• 122314-84-5 3-[(1S,2R,3aS,4R,7aS)-2-(tert-Butyl-dimethyl-silanyloxy)-1-isopropenyl-7a-methyl-6-oxo-octahydro-inden-4-yl]-propionic acid isopropyl ester 
• 104621-23-0 (2S,3R,3aR,7aS)-2-Hydroxy-3-isopropenyl-3a-methyl-octahydro-inden-5-one 
• 104621-29-6 (8S,9R,10R,13S,14S)-10,13-Dimethyl-17-[1-tripropylsilanyloxy-eth-(Z)-ylidene]-1,6,7,8,9,10,12,13,14,15,16,17-dodecahydro-2H-cyclopenta[a]phenanthrene-3,11-dione 
• 104621-22-9 [(1S,2R)-2-Methyl-2-(2-methyl-propenyl)-4-oxo-cyclohexyl]-acetaldehyde 
• 104621-24-1 (2S,3R,3aR,7aR)-3-Isopropenyl-3a-methyl-2-trimethylsilanyloxy-1,2,3,3a,4,7a-hexahydro-inden-5-one 
• 104621-25-2 3-((1S,2R,3aS,4R,7aS)-2-Hydroxy-1-isopropenyl-7a-methyl-6-oxo-octahydro-inden-4-yl)-propionic acid isopropyl ester 
• 104621-26-3 3-[(1S,2R,3aS,4R,7aS)-2-(tert-Butyl-dimethyl-silanyloxy)-1-isopropenyl-7a-methyl-6-oxo-octahydro-inden-4-yl]-propionic acid 
• 104621-28-5 (2R,3S,3aS,5aR,6R,9aS,9bS)-3-Acetyl-2-(tert-butyl-dimethyl-silanyloxy)-3a,6-dimethyl-6-(3-oxo-butyl)-decahydro-cyclopenta[a]naphthalene-5,7-dione 
• 104621-21-8 [(1S,2R)-2-Methyl-2-(2-methyl-propenyl)-4-oxo-cyclohexyl]-acetic acid tert-butyl ester 
• 104621-27-4 (3aR,7aS,8S,9R,10aS,10bS,10cS)-9-(tert-Butyl-dimethyl-silanyloxy)-8-isopropenyl-3a,6,7a-trimethyl-1,2,3a,5,7,7a,8,9,10,10a,10b,10c-dodecahydro-4H-cyclopenta[a]phenalen-3-one 
• 104621-29-6 (8S,9S,10R,13S,14S)-10,13-Dimethyl-17-[1-tripropylsilanyloxy-eth-(Z)-ylidene]-1,6,7,8,9,10,12,13,14,15,16,17-dodecahydro-2H-cyclopenta[a]phenanthrene-3,11-dione 
• 1882-86-6 (8S,9R,10R,13S,14S)-17-Acetyl-10,13-dimethyl-1,6,7,8,9,10,12,13,14,15-decahydro-2H-cyclopenta[a]phenanthrene-3,11-dione 
• 122314-93-6 (8R,9R,10S,13R,14R,16S,17R)-17-Acetyl-16-methoxy-10,13-dimethyl-1,6,7,8,9,10,12,13,14,15,16,17-dodecahydro-2H-cyclopenta[a]phenanthrene-3,11-dione 

Downstream Products

• 10215-75-5 Cortison-21-hydrogensuccinat 
• 10215-75-5 cortisone 21-hemisuccinate 
• 6865-15-2 17-hydroxy-21-undecanoyloxy-pregn-4-ene-3,11,20-trione 
• 85135-80-4 17-hydroxy-21-pivaloyloxy-pregn-4-ene-3,11,20-trione 
• 101524-47-4 3,3;20,20-bis-ethanediyldioxy-17,21-dihydroxy-pregn-5-en-11-one 
• 53-36-1 methylprednisolone acetate 
• 1625-11-2 21-acetoxy-11β,17-dihydroxy-6α-methyl-pregn-4-ene-3,20-dione 
• 83-43-2 Methylprednisolone 
• 382-45-6 adrenosterone 
• 1173-27-9 21-acetoxy-pregn-4-ene-3,11,20-trione 
• 1882-82-2 17-hydroxy-pregn-4-ene-3,11,20-trione 
• 5758-63-4 21-iodocortisone 
• 566-38-1 17α,20α,21-trihydroxy-pregn-4-ene-3,11-dione 

Relevant academic research and scientific papers

Total Synthesis of ( +/-)-Cortisone. Double-Hydroxylation Reaction for Corticoid Synthesis

Total syntheses of (+/-)-cortisone and (+/-)-adrenosterone have been achieved in 18 steps with the aid of metal-assisted new synthetic sequences in particular, ene reaction and homoenolate chemistry.A novel double-hydroxylation reaction of enol silyl ethers leading to a single step construction of the dihydroxyacetone side chain in corticoids has been developed and applied to the synthesis of cortisone, cortexolone, and 16α-methylcortexolone.