100114-32-7

Basic information

• Product Name: 1H-Tetrazole,1-(1-methylethyl)-(9CI)
• Synonyms: 1H-Tetrazole,1-(1-methylethyl)-(9CI);1-isopropyltetrazole;1-Isopropyl-1H-tetrazol;1-(1-METHYLETHYL)-1H-TETRAZOLE
• CAS NO: 100114-32-7
• Molecular Formula: C4H8N4
• Molecular Weight: 112.13312
• Product Categories: TRIAZOLE
• Mol File: 100114-32-7.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1H-Tetrazole,1-(1-methylethyl)-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Tetrazole,1-(1-methylethyl)-(9CI)(100114-32-7)
• EPA Substance Registry System: 1H-Tetrazole,1-(1-methylethyl)-(9CI)(100114-32-7)

Safety Data

• Hazardous Substances Data: 100114-32-7(Hazardous Substances Data)

Usage

General Description

1H-Tetrazole, 1-(1-methylethyl)-(9CI) is a chemical compound with the molecular formula C5H9N3. It is also known by its systematic name, 1-(1-methylethyl)-1H-tetrazole. 1H-Tetrazole,1-(1-methylethyl)-(9CI) is classified as a heterocyclic organic compound, containing a tetrazole ring structure. It is a colorless and odorless solid that is soluble in water and organic solvents. 1H-Tetrazole, 1-(1-methylethyl)-(9CI) has various industrial applications, including as a chemical intermediate in the synthesis of pharmaceuticals, agrochemicals, and polymer additives. It is also used as a stabilizer in propellants and explosives. Additionally, this compound is under research for potential applications in medicinal chemistry and as a building block in organic synthesis.

Upstream product

• 110840-11-4 1,1-diazido-2-methylpropane 
• 630-19-3 pivalaldehyde 
• 78-84-2 isobutyraldehyde 
• 75-26-3 isopropyl bromide 
• 75-31-0 isopropylamine 
• 122-51-0 orthoformic acid triethyl ester 

Relevant articles and documents

Microwave alkylation of lithium tetrazolate

Abstract: N1-substituted tetrazoles are interesting ligands in transition metal coordination chemistry, especially in the field of spin crossover. Their synthesis is performed in most cases according to the Franke-synthesis, using a primary amine as reagent introducing the substitution pattern. To enhance flexibility in means of substrate scope, we developed a new protocol based on alkylation of lithium tetrazolate with alkyl bromides. The N1–N2 isomerism of the tetrazole during the alkylation was successfully suppressed by use of highly pure lithium tetrazolate and 30?vol.% aqueous ethanol as solvent, leading to pure N1-substituted products. The feasibility of this reaction was demonstrated by a selection of different substrates. Graphical abstract: [Figure not available: see fulltext.]

APOPTOSIS SIGNAL-REGULATING KINASE 1 INHIBITORS AND METHODS OF USE THEREOF

The present invention discloses compounds of Formula (I), or pharmaceutically acceptable salts, ester, stereoisomer, tautomer, solvate, hydrate, or combination thereof: which inhibit the Apoptosis signal-regulating kinase 1 (ASK-1), which associated with autoimmune disorders, neurodegenerative disorders, inflammatory diseases, chronic kidney disease, cardiovascular disease. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from ASK-1 related disease. The invention also relates to methods of treating an ASK-1 related disease in a subject by administering a pharmaceutical composition comprising the compounds of the present invention. The present invention specifically relates to methods of treating ASK-1 associated with hepatic steatosis, including non-alcoholic fatty liver disease (NAFLD) and non-alcohol steatohepatitis disease (NASH).