100117-84-8

Usage

Uses

Used in Organic Chemistry:
4-(4-METHOXY-PHENYL)-3-OXO-BUTYRIC ACID METHYL ESTER is used as a building block for various organic chemical reactions, contributing to the synthesis of complex organic molecules and facilitating the development of new chemical compounds.
Used in Pharmaceutical Research:
In the pharmaceutical industry, 4-(4-METHOXY-PHENYL)-3-OXO-BUTYRIC ACID METHYL ESTER is utilized as a key intermediate in the synthesis of pharmaceuticals. Its unique structure allows it to be a valuable component in the development of new drugs, potentially leading to advancements in medicinal chemistry.
Used in Synthesis of Active Pharmaceutical Ingredients (APIs):
4-(4-METHOXY-PHENYL)-3-OXO-BUTYRIC ACID METHYL ESTER is employed as a precursor in the synthesis of active pharmaceutical ingredients. Its presence in the molecular structure of certain APIs can contribute to the desired pharmacological properties, such as increased bioavailability, enhanced efficacy, or improved safety profiles.
Used in Drug Development:
As a component in drug development, 4-(4-METHOXY-PHENYL)-3-OXO-BUTYRIC ACID METHYL ESTER aids in the discovery and optimization of new drug candidates. Its versatile chemical properties enable researchers to explore its potential in various therapeutic areas, including but not limited to, pain management, inflammation, and central nervous system disorders.

Upstream product

• 105-45-3 acetoacetic acid methyl ester 
• 4693-91-8 4-methoxyphenyl-acetic chloride 
• 104-01-8 4-Methoxyphenylacetic acid 
• 38330-80-2 monomethyl monopotassium malonate 
• 104-92-7 1-bromo-4-methoxy-benzene 
• 74590-73-1 1,3-bis(trimethylsiloxy)-1-methoxybuta-1,3-diene 
• 81190-04-7 C₁₂H₁₄O₃ 
• 79-20-9 acetic acid methyl ester 

Downstream Products

• 100390-83-8 3-Amino-4-<4-methoxy-phenyl>-crotonsaeure-methylester 
• 1137829-46-9 C₁₅H₂₂O₄Si 
• 1393642-87-9 methyl 2-diazo-4-(4-methoxyphenyl)-3-oxobutanoate 
• 102076-58-4 3-(2-Methoxycarbonyl-aethylamino)-4-(4-methoxy-phenyl)-crotonsaeure-methylester 

Relevant academic research and scientific papers

Hauser-Heck: Efficient Synthesis of γ-Aryl-β-ketoesters en Route to Substituted Naphthalenes

γ-Aryl-β-ketoesters can be prepared in one step from aryl bromides and bis(trimethylsilyl) enol ethers using catalytic amounts of Pd(dba)2/t-Bu3P and stoichiometric amounts of Bu3SnF. The wide range of γ-(hetero)aryl-β-ketoesters that can be obtained illustrate the scope and limitations of this novel Hauser-Heck combination. γ-Aryl-β-ketoesters with a 1,3-dioxane acetal in the ortho position can easily be transformed into the hydroxy naphthoate in very good yield. Aqueous formic acid at 65 °C provides optimal conditions for this deprotective aromatization.

Donor-Acceptor-Acceptor 1,3-Bisdiazo Compounds: An Exploration of Synthesis and Stepwise Reactivity

Metal carbenes, derived from the decomposition of diazo compounds, are valued for their capacity to perform a variety of transformations. A unique class of acyclic, bis-diazo compounds, the donor-acceptor-acceptor 1,3-bisdiazo compounds, are described her

Highly atom-efficient oxidation of electron-deficient internal olefins to ketones using a palladium catalyst

A 100 % atom-efficient synthesis of ketones from electron-deficient internal olefins was achieved using O2 as a "green" oxidant (see scheme, DMA=N,N-dimethylacetamide, EWG=electron-withdrawing group). Various electron-deficient olefins were oxidized to the corresponding ketones with over 99 % selectivity and without the formation of olefin isomers or their oxidized products. Copyright

Regioselective synthesis of functionalized biaryls based on the first [3+3] cyclocondensations of 4-Aryl-1,3-bis(trimethylsilyloxy)buta-1,3-dienes

Sterically encumbered biaryls were regioselectively prepared by formal [3+3] cyclocondensations of novel 4-aryl-1,3- bis(trimethylsilyloxy)-1,3-dienes. Georg Thieme Verlag Stuttgart · New York.