100117-84-8

Basic information

• Product Name: 4-(4-METHOXY-PHENYL)-3-OXO-BUTYRIC ACID METHYL ESTER
• Synonyms: 4-(4-METHOXY-PHENYL)-3-OXO-BUTYRIC ACID METHYL ESTER;4-METHOXY-BETA-OXO-BENZENEBUTANOIC ACID METHYL ESTER;Methyl 4-(4-methoxyphenyl)-3-oxobutanoate;Methyl 4-methoxy-b-oxo-benzenebutanoate
• CAS NO: 100117-84-8
• Molecular Formula: C₁₂H₁₄O₄
• Molecular Weight: 222.24
• Mol File: 100117-84-8.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-(4-METHOXY-PHENYL)-3-OXO-BUTYRIC ACID METHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(4-METHOXY-PHENYL)-3-OXO-BUTYRIC ACID METHYL ESTER(100117-84-8)
• EPA Substance Registry System: 4-(4-METHOXY-PHENYL)-3-OXO-BUTYRIC ACID METHYL ESTER(100117-84-8)

Safety Data

• Hazardous Substances Data: 100117-84-8(Hazardous Substances Data)

Usage

General Description

4-(4-methoxy-phenyl)-3-oxo-butyric acid methyl ester is a chemical compound with the molecular formula C12H14O4. It is also known as methyl 4-(4-methoxyphenyl)-3-oxobutanoate. 4-(4-METHOXY-PHENYL)-3-OXO-BUTYRIC ACID METHYL ESTER is used in the field of organic chemistry and pharmaceutical research. It is a methyl ester derivative of an oxo-carboxylic acid and contains a phenyl ring with a methoxy group attached. 4-(4-methoxy-phenyl)-3-oxo-butyric acid methyl ester has potential applications in the synthesis of pharmaceuticals and as a building block in organic chemical reactions.

Upstream product

• 104-01-8 4-Methoxyphenylacetic acid 
• 38330-80-2 monomethyl monopotassium malonate 
• 105-45-3 acetoacetic acid methyl ester 
• 104-92-7 1-bromo-4-methoxy-benzene 
• 74590-73-1 1,3-bis(trimethylsiloxy)-1-methoxybuta-1,3-diene 
• 81190-04-7 C₁₂H₁₄O₃ 
• 79-20-9 acetic acid methyl ester 
• 4693-91-8 4-methoxyphenyl-acetic chloride 

Downstream Products

• 1137829-46-9 C₁₅H₂₂O₄Si 
• 1393642-87-9 methyl 2-diazo-4-(4-methoxyphenyl)-3-oxobutanoate 
• 102076-58-4 3-(2-Methoxycarbonyl-aethylamino)-4-(4-methoxy-phenyl)-crotonsaeure-methylester 
• 100390-83-8 3-Amino-4-<4-methoxy-phenyl>-crotonsaeure-methylester 

Relevant articles and documents

Hauser-Heck: Efficient Synthesis of γ-Aryl-β-ketoesters en Route to Substituted Naphthalenes

γ-Aryl-β-ketoesters can be prepared in one step from aryl bromides and bis(trimethylsilyl) enol ethers using catalytic amounts of Pd(dba)2/t-Bu3P and stoichiometric amounts of Bu3SnF. The wide range of γ-(hetero)aryl-β-ketoesters that can be obtained illustrate the scope and limitations of this novel Hauser-Heck combination. γ-Aryl-β-ketoesters with a 1,3-dioxane acetal in the ortho position can easily be transformed into the hydroxy naphthoate in very good yield. Aqueous formic acid at 65 °C provides optimal conditions for this deprotective aromatization.

Highly atom-efficient oxidation of electron-deficient internal olefins to ketones using a palladium catalyst

A 100 % atom-efficient synthesis of ketones from electron-deficient internal olefins was achieved using O2 as a "green" oxidant (see scheme, DMA=N,N-dimethylacetamide, EWG=electron-withdrawing group). Various electron-deficient olefins were oxidized to the corresponding ketones with over 99 % selectivity and without the formation of olefin isomers or their oxidized products. Copyright