100117-99-5Relevant academic research and scientific papers
Novel Pyrimidine Toll-like Receptor 7 and 8 Dual Agonists to Treat Hepatitis B Virus
McGowan, David,Herschke, Florence,Pauwels, Frederik,Stoops, Bart,Last, Stefaan,Pieters, Serge,Scholliers, Annick,Thoné, Tine,Van Schoubroeck, Bertrand,De Pooter, Dorien,Mostmans, Wendy,Khamlichi, Mourad Daoubi,Embrechts, Werner,Dhuyvetter, Deborah,Smyej, Ilham,Arnoult, Eric,Demin, Samu?l,Borghys, Herman,Fanning, Gregory,Vlach, Jaromir,Raboisson, Pierre
, p. 7936 - 7949 (2016/11/07)
Toll-like receptor (TLR) 7 and 8 agonists can potentially be used in the treatment of viral infections and are particularly promising for chronic hepatitis B virus (HBV) infection. An internal screening effort identified a pyrimidine Toll-like receptor 7 and 8 dual agonist. This provided a novel alternative over the previously reported adenine and pteridone type of agonists. Structure-activity relationship, lead optimization, in silico docking, pharmacokinetics, and demonstration of ex vivo and in vivo cytokine production of the lead compound are presented.
INHIBITORS OF CATECHOL O-METHYL TRANSFERASE AND THEIR USE IN THE TREATMENT OF PSYCHOTIC DISORDERS
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Page/Page column 49, (2011/10/03)
The present invention relates to 4-pyridinone compounds which are inhibitors of catechol O-methyltransferase (COMT), and are useful in the treatment and prevention of neurological and psychiatric disorders and diseases in which COMT enzyme is involved. The present invention also relates to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which COMT is involved.
