93534-87-3

Basic information

• Product Name: 2-aMino-5-(benzyloxy)pyriMidin-4(3H)-one
• Synonyms: 2-aMino-5-(benzyloxy)pyriMidin-4(3H)-one;2-amino-5-(benzyloxy)pyrimidin-4-ol;2-amino-5-(benzyloxy)pyrimidin-4-ol(WXC04304)
• CAS NO: 93534-87-3
• Molecular Formula: C₁₁H₁₁N₃O₂
• Molecular Weight: 217.22394
• Mol File: 93534-87-3.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 473.2°Cat760mmHg
• Flash Point: 240°C
• Appearance: /
• Density: 1.33g/cm³
• Vapor Pressure: 1.41E-09mmHg at 25°C
• Refractive Index: 1.637
• PKA: 8.77±0.50(Predicted)
• CAS DataBase Reference: 2-aMino-5-(benzyloxy)pyriMidin-4(3H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 2-aMino-5-(benzyloxy)pyriMidin-4(3H)-one(93534-87-3)
• EPA Substance Registry System: 2-aMino-5-(benzyloxy)pyriMidin-4(3H)-one(93534-87-3)

Safety Data

• Hazardous Substances Data: 93534-87-3(Hazardous Substances Data)

Usage

Heterocyclic compound

Contains a pyrimidine ring with an amino group and a benzyloxy group attached

Potential biological activities

Studied for anti-cancer, anti-inflammatory, and anti-viral properties
Used as a building block for synthesis of bioactive molecules
Potential applications in medicinal chemistry
Valuable tool in search for new drugs and therapies

InChI:InChI=1/C11H11N3O2/c12-11-13-6-9(10(15)14-11)16-7-8-4-2-1-3-5-8/h1-6H,7H2,(H3,12,13,14,15)

Upstream product

• 593-85-1 guanidine carbonate 
• 100117-99-5 2-benzyloxy-3-oxo-propionic acid ethyl ester 
• 32122-09-1 ethyl benzyloxyacetate 
• 113-00-8 guanidine nitrate 
• 109-94-4 formic acid ethyl ester 
• 100-39-0 benzyl bromide 

Downstream Products

• 1402805-39-3 C₁₃H₁₃N₃O₃ 
• 1402805-25-7 5-(benzyloxy)-4-chloropyrimidin-2-amine 
• 1402805-26-8 C₁₉H₂₄N₄O₃ 
• 1402805-28-0 4-(butylamino)-5-benzyloxy-2-(bis-boc-amino)pyrimidine 
• 1402805-32-6 C₁₆H₂₂N₄O₂ 
• 1402805-33-7 C₂₂H₂₈N₄O₅ 
• 1402805-40-6 C₁₃H₁₂ClN₃O₂ 
• 1402805-41-7 C₂₀H₂₆N₄O₄ 
• 1402805-42-8 C₁₉H₂₆N₄O₃ 
• 1402805-46-2 C₂₀H₂₈N₄O₃ 
• 1402805-60-0 C₁₉H₂₆N₄O₃ 
• 1402801-92-6 5-(benzyloxy)-N⁴-butylpyrimidine-2,4-diamine 
• 40769-68-4 2-amino-5-hydroxy-3H-pyrimidin-4-one 

Relevant articles and documents

Novel Pyrimidine Toll-like Receptor 7 and 8 Dual Agonists to Treat Hepatitis B Virus

Toll-like receptor (TLR) 7 and 8 agonists can potentially be used in the treatment of viral infections and are particularly promising for chronic hepatitis B virus (HBV) infection. An internal screening effort identified a pyrimidine Toll-like receptor 7 and 8 dual agonist. This provided a novel alternative over the previously reported adenine and pteridone type of agonists. Structure-activity relationship, lead optimization, in silico docking, pharmacokinetics, and demonstration of ex vivo and in vivo cytokine production of the lead compound are presented.

PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF VIRAL INFECTIONS

This invention relates to pyrimidine derivatives, processes for their preparation, pharmaceutical compositions, and their use in treating viral infections such as HCV or HBV.