100126-96-3Relevant academic research and scientific papers
α-Fluoro analogues of inflammation inhibiting α-arylpropionic acids
Schlosser, Manfred,Michel, Dominique,Guo, Zhi-Wei,Sih, Charles J.
, p. 8257 - 8262 (1996)
2-Aryl-2-fluoropropionic acids were prepared by treatment of either ethyl α-hydroxy-carboxylates or cyanohydrin O-silyl ethers with diethylaminosulfur trifluoride and subsequent hydrolysis. The methyl ester of 2-fluoro-2-(4- isobutylphenyl)propionic acid
Highly homogeneous stereocontrolled construction of quaternary hydroxyesters by addition of dimethylzinc to α-ketoesters promoted by chiral perhydrobenzoxazines and B(OEt)3
Infante, Rebeca,Nieto, Javier,Andres, Celia
, p. 4375 - 4379 (2012/05/20)
A highly efficient enantioselective addition of Me2Zn to α-ketoesters, assisted by a chiral perhydro-1,3-benzoxazine ligand, is described. This novel catalytic system offers homogeneous elevated enantioselectivities in the preparation of α-hydroxyesters that bear a quaternary stereocenter, with a minor dependence on electronic and steric effects when aromatic, heteroaromatic, or aliphatic α-ketoesters are employed. The catalyst can be recovered and reused without loss of activity.
Propargylether derivatives
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, (2008/06/13)
Propargylether derivatives of formula I including the optical isomers thereof and mixtures of such isomers, wherein R1is hydrogen, alkyl, cycloalkyl or optionally substituted aryl, R2and R3are each independently hydrogen o
