34966-48-8

Basic information

• Product Name: ETHYL 4-CHLOROBENZOYLFORMATE
• Synonyms: (4-CHLOROPHENYL)GLYOXYLIC ACID ETHYL ESTER;ETHYL 4-CHLOROBENZOYLFORMATE;ETHYL 2-(2,4-DICHLOROPHENYL)-2-OXOACETATE;ETHYL 2-(4-CHLOROPHENYL)-2-OXOACETATE;Ethyl (4-chlorophenyl)(oxo)acetate;Ethyl 4-chlorobenzoylformate Ethyl 2-(2,4-dichlorophenyl)-2-oxoacetate (4-Chlorophenyl)glyoxylic acid ethyl ester;Ethyl 4-chlorobenzoylformate, Ethyl 4-chlorophenylglyoxylate;Ethyl 4-chlorophenylglyoxylate
• CAS NO: 34966-48-8
• Molecular Formula: C₁₀H₉ClO₃
• Molecular Weight: 212.63
• Product Categories: Aromatic Esters
• Mol File: 34966-48-8.mol
• Article Data: 44

Chemical Properties

• Boiling Point: 85°C/0.1mm
• Flash Point: 129 °C
• Appearance: /
• Density: 1.255 g/cm³
• Vapor Pressure: 0.000837mmHg at 25°C
• Refractive Index: 1.528
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: ETHYL 4-CHLOROBENZOYLFORMATE(CAS DataBase Reference)
• NIST Chemistry Reference: ETHYL 4-CHLOROBENZOYLFORMATE(34966-48-8)
• EPA Substance Registry System: ETHYL 4-CHLOROBENZOYLFORMATE(34966-48-8)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 34966-48-8(Hazardous Substances Data)

Usage

General Description

Ethyl 4-chlorobenzoylformate is a chemical compound with the molecular formula C10H9ClO3. It is a colorless to yellow liquid with a fruity odor, and is primarily used in the production of pharmaceuticals and agrochemicals. ETHYL 4-CHLOROBENZOYLFORMATE is an acylating agent, meaning it is used to transfer an acyl group from one molecule to another, and is commonly employed in the synthesis of various organic compounds. Ethyl 4-chlorobenzoylformate is considered to be a hazardous substance and should be handled with caution, as it can cause irritation to the skin, eyes, and respiratory system upon exposure.

InChI:InChI=1/C10H9ClO3/c1-2-14-10(13)9(12)7-3-5-8(11)6-4-7/h3-6H,2H2,1H3

Upstream product

• 106-39-8 bromochlorobenzene 
• 75716-82-4 imidazol-1-yl-oxo-acetic acid ethyl ester 
• 4755-77-5 Ethyl oxalyl chloride 
• 108-90-7 chlorobenzene 
• 4383-55-5 3-hydroxy-2-(4-chlorophenyl)acrylic acid ethyl ester 
• 95-92-1 oxalic acid diethyl ester 
• 122-01-0 4-chloro-benzoyl chloride 
• 873-77-8 (4-chlorphenyl)magnesium bromide 
• 13511-29-0 ethyl 2-(4-chlorophenyl)-2-hydroxyacetate 
• 64-17-5 ethanol 
• 28587-05-5 3-dimethylamino-1(4-chloro-phenyl)-2-propen-1-one 
• 33491-03-1 1-(bromoethynyl)-4-chlorobenzene 
• 14062-24-9 4-chloro-benzeneacetic acid, ethyl ester 
• 1878-66-6 4-chlorophenylacetic Acid 

Downstream Products

• 93089-21-5 Cyclohexyl-<4-chlor-phenyl>-glykolsaeure-aethylester 
• 7099-88-9 4-chlorophenylglyoxylic acid 
• 510-15-6 chlorobenzilate 
• 916058-72-5 ethyl (p-chlorophenyl)-[N-(p-methoxyphenyl)imino]acetate 
• 925459-57-0 3-allylmercapto-6-(4-chlorophenyl)-4H-[1,2,4]triazin-5-one 
• 4017-20-3 3-(4-chlorophenyl)quinoxalin-2(1H)-one 
• 1196795-92-2 3-(4-chlorophenyl)-2H-benzo[b][1,4]oxazin-2-one 
• 1223562-86-4 (1R,2S,5R)-5-methyl-2-(1-methylethyl)cyclohexyl (4-chlorophenyl)(oxo)acetate 
• 100126-96-3 ethyl 2-(4-chlorophenyl)-2-hydroxypropionate 

Relevant articles and documents

Diastereoselective Synthesis of α-Quaternary Aziridine-2-carboxylates via Aza-Corey-Chaykovsky Aziridination of N-tert-Butanesulfinyl Ketimino Esters

A general, scalable, and highly diastereoselective aziridination of N-tert-butanesulfinyl ketimino esters is described. The methodology has been utilized to provide straightforward access to previously unobtainable, biologically relevant α-quaternary amino esters and derivatives starting from readily available precursors.

Stereoselective Synthesis of Dihydrocoumarins via [1,2]-Phospha-Brook Rearrangement in Three-Component Coupling Reaction of α-Ketoesters, o-Quinone Methides, and Dialkyl Phosphites

A highly regio- and diastereoselective approach for the synthesis of phosphate substituted dihydrocoumarins via Br?nsted base catalyzed [1,2]-phospha-Brook rearrangement is reported. The two-step, one-pot Michael addition of α-phosphonyloxy enolates proceeds by coupling of dialkyl phosphite and α-ketoesters to o-quinone methides, followed by an intramolecular cyclization, providing 3,4-dihydrocoumarin frameworks.

Copper on charcoal: Cu0nanoparticle catalysed aerobic oxidation of α-diazo esters

By using a charcoal supported nano Cu0catalyst (Cu/C), a highly efficient oxidation of α-diazo esters to α-ketoesters with molecular oxygen as the sole oxidant has been developed. In the presence of the Cu/C catalyst, 2-aryl-α-diazo esters with both electron-donating and electron-withdrawing groups can be oxidized to the corresponding α-ketoesters efficiently. Furthermore, this Cu/C catalyst can catalyse the reaction of aryl α-diazo ester with water to form aryl ketoester, 2-aryl-2-hydroxyl acetate ester and 2-aryl acetate ester. In this case, water is split by α-diazo ester, and the diazo group is displaced by the oxygen or hydrogen atom in water. Mechanistic investigation showed that the reaction of α-diazo ester with oxygen proceeds through a radical pathway. In the presence of 2,2,6,6-tetramethyl piperidine nitrogen oxide, the reaction of α-diazo ester with oxygen is dramatically inhibited. Furthermore, the reaction of α-diazo ester with water is investigated by an isotopic tracer method, and GCMS detection showed that a disproportionation reaction occurred between α-diazo ester and water.