100134-56-3

Upstream product

• 939-03-7 3-methyl-5-phenyl-4,5-dihydro-1H-pyrazole 
• 108-24-7 acetic anhydride 
• 75-36-5 acetyl chloride 
• 1896-62-4 (E)-benzalacetone 
• 100-52-7 benzaldehyde 
• 64-19-7 acetic acid 
• 122-57-6 1-Phenylbut-1-en-3-one 

Downstream Products

• 76588-07-3 1-acetyl-2-ethyl-3-phenyl-5-methylpyrazolidine 
• 1354551-32-8 2-bromo-1-(3-methyl-5-phenyl-4,5-dihydropyrazol-1-yl)ethanone 

Relevant academic research and scientific papers

Synthesis, characterization and microbial activity of N-substituted pyrazolines

Acetic acid and propanoic acid were treated with thionyl chloride to give respective acid chlorides, which were then reacted with synthesized pyrazolines using triethylamine as catalyst in dry dichloromethane to give N-acetylated pyrazolines (1b-7b) and N

Novel 2-(benzo[d]thiazol-2-yl)-1-(3-methyl-5-substituted-phenyl-4,5- dihydropyrazol-1-yl)ethanone Derivatives: Synthesis and antibacterial activity

A series of novel 2-(benzo[d]thiazol-2-yl)-1-(3-methyl-5-substituted- phenyl-4,5-dihydropyrazol-1-yl)ethanone derivatives were synthesized and characterized by NMR, ESI-MS. Biological activity tests results show that compounds 4a, 4b, 4d and 4g displayed activity with MIC of 1.562 ?g/mL against B. subtilis ATCC 6633, compound 4d displayed significant activity with MIC of 1.562 μg/mL against S. aureus ATCC 6538. Compound 4a with potent antibacterial activities strongly inhibited S. aureus DNA gyrase and B. subtilis DNA gyrase with IC50s of 0.5 μg/ml against S. aureus DNA gyrase and B. subtilis DNA gyrase.