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Remimazolam (benzenesulfonate) is a water-soluble benzodiazepine derivative that is being developed as a short-acting sedative for use in procedural sedation and general anesthesia. It acts on the gamma-aminobutyric acid (GABA) receptor in the brain, producing sedative, anxiolytic, amnestic, and muscle relaxant effects. Its rapid onset and short duration of action make it an attractive option for use in medical procedures, as it allows for quick recovery and discharge of the patient.

1001415-66-2

1001415-66-2 Suppliers

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1001415-66-2 Usage

Uses

Used in Medical Procedures:
Remimazolam (benzenesulfonate) is used as a short-acting sedative for procedural sedation and general anesthesia, providing sedative, anxiolytic, amnestic, and muscle relaxant effects during medical procedures.
Used in Colonoscopy:
Remimazolam (benzenesulfonate) is used as a sedative during colonoscopy, offering rapid onset and short duration of action, which allows for quick recovery and discharge of the patient.
Used in Minor Surgical Procedures:
Remimazolam (benzenesulfonate) is used as a sedative for minor surgical procedures, providing effective sedation and muscle relaxation while enabling quick recovery and discharge of the patient.
Used in Anesthesia:
Remimazolam (benzenesulfonate) is being further studied for its potential applications in anesthesia, due to its rapid onset and short duration of action, which may offer advantages over traditional anesthetic agents.

Check Digit Verification of cas no

The CAS Registry Mumber 1001415-66-2 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,0,0,1,4,1 and 5 respectively; the second part has 2 digits, 6 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 1001415-66:
(9*1)+(8*0)+(7*0)+(6*1)+(5*4)+(4*1)+(3*5)+(2*6)+(1*6)=72
72 % 10 = 2
So 1001415-66-2 is a valid CAS Registry Number.

1001415-66-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name Remimazolam benzenesulfonate

1.2 Other means of identification

Product number -
Other names CN-7056 benzenesulfonate

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:1001415-66-2 SDS

1001415-66-2Downstream Products

1001415-66-2Relevant academic research and scientific papers

Preparation method of benzodiazepine drugs

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Paragraph 0042-0045; 0050-0053; 0067, (2021/02/06)

The invention discloses a preparation method of benzodiazepine drugs. The method comprises the following steps: (1) reacting an intermediate shown as a formula II with dimorpholinophosphoryl chloride(BMPC) in the presence of lithium diisopropylamide to generate an active intermediate, adding 1-amino 2-propanol of raceme, and treating after the reaction is ended, recrystallizing methyl tert-butylether to obtain an intermediate refined product shown in a formula III; and (2) oxidizing the intermediate refined product shown in the formula III obtained in the step (1), and performing cyclizationand salification by using benzenesulfonic acid to separate out a compound shown in a formula I. Compared with the prior art, the method is easy and convenient to operate, low in cost, high in yield and suitable for industrial production.

METHOD FOR PREPARING 3-[(4S)-8-BROMO-1-METHYL-6-(PYRIDIN-2-YL)-4H-IMIDAZO[1,2-A][1,4]BENZODIAZEPIN-4-YL]-PROPIONIC ACID METHYL ESTER, AND COMPOUNDS USEFUL IN SAID METHOD

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, (2019/05/02)

The present invention relates to a method for preparing 3- [ ( 4S ) -8-bromo-l-methyl-6- (pyridin-2-yl ) -4H-imidazo [1,2- a] [ 1, 4 ] benzodiazepin-4-yl ] -propionic acid methyl ester starting from 3- [ (3S) -7-bromo-2-oxo-5- (pyridin-2-yl ) -2, 3-dihydr

OXIDATION REACTION EXCELLENT IN CONVERSION RATE

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Paragraph 0219-0231, (2016/02/26)

A process for preparing 3-[(S)-7-bromo-2-(2-oxo-propylamino)-5-pyridin-2-yl-3H-1,4,-benzodiazepin-3-yl]propionic acid methyl ester at a high conversion rate with good reproducibility by oxidizing 3-[(S)-7-bromo-2-(2-hydroxy-propylamino)-5-pyridin-2-yl-3H-benzo[e][1,4]diazepin-3-yl]propionic acid methyl ester in the presence of an oxidation catalyst is provided by defining the ammonium ion content of 3-[(S)-7-bromo-2-(2-hydroxy-propylamino)-5-pyridin-2-yl-3H-benzo[e][1,4]diazepin-3-yl]propionic acid methyl ester.

SHORT-ACTING BENZODIAZEPINE SALTS AND THEIR POLYMORPHIC FORMS

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Page/Page column 18, (2008/06/13)

The invention relates to besylate salts of the compound of formula (I):Methods of preparing the salts, and their use as medicaments, in particular for sedative or hypnotic, anxiolytic, muscle relaxant, or anticonvulsant purposes is also described.