1001792-87-5

Basic information

• Product Name: 2-(3,4-dichlorophenyl)-N-[2-(pyrrolidin-1-yl)phenyl]acetamide
• CAS NO: 1001792-87-5
• Molecular Weight: 349.26
• Mol File: 1001792-87-5.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2-(3,4-dichlorophenyl)-N-[2-(pyrrolidin-1-yl)phenyl]acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(3,4-dichlorophenyl)-N-[2-(pyrrolidin-1-yl)phenyl]acetamide(1001792-87-5)
• EPA Substance Registry System: 2-(3,4-dichlorophenyl)-N-[2-(pyrrolidin-1-yl)phenyl]acetamide(1001792-87-5)

Safety Data

• Hazardous Substances Data: 1001792-87-5(Hazardous Substances Data)

Upstream product

• 40832-79-9 1-(2-nitrophenyl)pyrrolidine 
• 88-73-3 2-Chloronitrobenzene 
• 5807-30-7 3,4-dichlorophenyl acetic acid 
• 21627-58-7 2-(pyrrolidin-1-yl)-phenylamine 

Relevant articles and documents

Discovery of a series of 2-phenyl- N -(2-(pyrrolidin-1-yl)phenyl)acetamides as novel molecular switches that modulate modes of Kv7.2 (KCNQ2) channel pharmacology: Identification of (S)-2-phenyl- N -(2-(pyrrolidin-1-yl) phenyl)butanamide (ML252) as a potent, brain penetrant Kv7.2 channel inhibitor

A potent and selective inhibitor of KCNQ2, (S)-5 (ML252, IC50 = 69 nM), was discovered after a high-throughput screen of the MLPCN library was performed. SAR studies revealed a small structural change (ethyl group to hydrogen) caused a functional shift from antagonist to agonist activity (37, EC50 = 170 nM), suggesting an interaction at a critical site for controlling gating of KCNQ2 channels.