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21627-58-7

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21627-58-7 Usage

General Description

2-Pyrrolidin-1-ylaniline 97 is a chemical compound from the group of pyrrolidines, which are organic compounds containing a pyrrolidine ring in their structure. This chemical is used in various industrial applications due to its stability and reactive properties. Its purity is denoted as 97%, indicating that it is a relatively high-grade compound. The exact uses and properties of this compound can vary and further information should be sought for specific applications. As with all chemicals, proper safety measures should be observed while handling 2-Pyrrolidin-1-ylaniline 97 to avoid any potential hazards or risks.

Check Digit Verification of cas no

The CAS Registry Mumber 21627-58-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,1,6,2 and 7 respectively; the second part has 2 digits, 5 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 21627-58:
(7*2)+(6*1)+(5*6)+(4*2)+(3*7)+(2*5)+(1*8)=97
97 % 10 = 7
So 21627-58-7 is a valid CAS Registry Number.
InChI:InChI=1/C10H14N2/c11-9-5-1-2-6-10(9)12-7-3-4-8-12/h1-2,5-6H,3-4,7-8,11H2

21627-58-7 Well-known Company Product Price

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  • Aldrich

  • (CBR01252)  (2-Pyrrolidin-1-ylphenyl)amine  AldrichCPR

  • 21627-58-7

  • CBR01252-1G

  • 1,611.09CNY

  • Detail

21627-58-7SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-pyrrolidin-1-ylaniline

1.2 Other means of identification

Product number -
Other names o-pyrrolidinylaniline

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:21627-58-7 SDS

21627-58-7Relevant articles and documents

Optimisation of 2-(N-phenyl carboxamide) triazolopyrimidine antimalarials with moderate to slow acting erythrocytic stage activity

Bailey, Brodie L.,Nguyen, William,Ngo, Anna,Goodman, Christopher D.,Gancheva, Maria R.,Favuzza, Paola,Sanz, Laura M.,Gamo, Francisco-Javier,Lowes, Kym N.,McFadden, Geoffrey I.,Wilson, Danny W.,Laleu, Beno?t,Brand, Stephen,Jackson, Paul F.,Cowman, Alan F.,Sleebs, Brad E.

, (2021/08/30)

Malaria is a devastating parasitic disease caused by parasites from the genus Plasmodium. Therapeutic resistance has been reported against all clinically available antimalarials, threatening our ability to control the disease and therefore there is an ongoing need for the development of novel antimalarials. Towards this goal, we identified the 2-(N-phenyl carboxamide) triazolopyrimidine class from a high throughput screen of the Janssen Jumpstarter library against the asexual stages of the P. falciparum parasite. Here we describe the structure activity relationship of the identified class and the optimisation of asexual stage activity while maintaining selectivity against the human HepG2 cell line. The most potent analogues from this study were shown to exhibit equipotent activity against P. falciparum multidrug resistant strains and P. knowlesi asexual parasites. Asexual stage phenotyping studies determined the triazolopyrimidine class arrests parasites at the trophozoite stage, but it is likely these parasites are still metabolically active until the second asexual cycle, and thus have a moderate to slow onset of action. Non-NADPH dependent degradation of the central carboxamide and low aqueous solubility was observed in in vitro ADME profiling. A significant challenge remains to correct these liabilities for further advancement of the 2-(N-phenyl carboxamide) triazolopyrimidine scaffold as a potential moderate to slow acting partner in a curative or prophylactic antimalarial treatment.

Access to Polycyclic Indole-3,4-Fused Nine-Membered Ring via Cascade 1,6-Hydride Transfer/Cyclization

Yang, Shuo,An, Xiao-De,Qiu, Bin,Liu, Rui-Bin,Xiao, Jian

, p. 9100 - 9105 (2021/11/24)

A cascade aldimine condensation/1,6-hydride transfer/Mannich-type cyclization of indole-derived phenylenediamine with aldehydes was developed for one-step construction of a polycyclic indole-3,4-fused skeleton. Aldehyde serves as a key to start the whole process, including 1,6-hydride transfer enabled δ-C(sp3)-H activation of the secondary amine. The challenges of construction of medium-sized rings are addressed via hydride transfer chemistry.

Photoswitching of ortho-Aminated Arylazopyrazoles with Red Light

Simke, Julian,B?sking, Tom,Ravoo, Bart Jan

supporting information, p. 7635 - 7639 (2021/10/05)

Bidirectional photoswitching of arylazopyrazoles with visible light is enabled by substitution with pyrrolidine and piperidine in the ortho-position of the phenyl ring. The absorption maxima were red-shifted and the molar absorption coefficients in the vi

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