40832-79-9

Basic information

• Product Name: 1-(2-NITRO-PHENYL)-PYRROLIDINE
• Synonyms: 1-(2-NITRO-PHENYL)-PYRROLIDINE;1-(Pyrrolidin-1-yl)-2-nitrobenzene;2-Nitro-1-pyrrolidinobenzene
• CAS NO: 40832-79-9
• Molecular Formula: C₁₀H₁₂N₂O₂
• Molecular Weight: 192.21
• Mol File: 40832-79-9.mol
• Article Data: 31

Chemical Properties

• Appearance: /Solid
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 1-(2-NITRO-PHENYL)-PYRROLIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2-NITRO-PHENYL)-PYRROLIDINE(40832-79-9)
• EPA Substance Registry System: 1-(2-NITRO-PHENYL)-PYRROLIDINE(40832-79-9)

Safety Data

• Hazardous Substances Data: 40832-79-9(Hazardous Substances Data)

Usage

General Description

1-(2-Nitro-phenyl)-pyrrolidine is a chemical compound with the molecular formula C11H12N2O2. It is a pyrrolidine derivative with a nitrophenyl group attached to the nitrogen atom. 1-(2-NITRO-PHENYL)-PYRROLIDINE is used in the synthesis of pharmaceuticals and agrochemicals. It has been studied for its potential as a precursor in the production of bioactive molecules and has shown promising results in various biological assays. Additionally, it has been investigated for its potential use in organic electronics due to its unique structural and electronic properties. 1-(2-Nitro-phenyl)-pyrrolidine is of interest to researchers in various fields due to its versatile applications and potential for further development.

Upstream product

• 123-75-1 pyrrolidine 
• 577-19-5 2-nitrophenyl bromide 
• 609-73-4 o-nitroiodobenzene 
• 696-59-3 cis,trans-2,5-dimethoxytetrahydrofuran 
• 88-74-4 2-nitro-aniline 
• 120-94-5 1-Methylpyrrolidine 
• 88-73-3 2-Chloronitrobenzene 
• 1493-27-2 ortho-nitrofluorobenzene 

Downstream Products

• 7724-48-3 2,3-dihydro-1H-pyrrolo[1,2-a]benzimidazole 
• 1001792-87-5 2-(3,4-dichlorophenyl)-N-[2-(pyrrolidin-1-yl)phenyl]acetamide 
• 21627-58-7 2-(pyrrolidin-1-yl)-phenylamine 
• 90158-91-1 N,N'-Bis-(2-pyrrolidin-1-yl-phenyl)-diazene N-oxide 

Relevant articles and documents

CYCLAMINEPHENYLAMINOQUINOLINES AS FUNGICIDES

The present disclosure relates to fungicidal active compounds, more specifically to cyclaminephenylaminoquinolines of formula (I), intermediates for their preparation and use thereof as fungicidal active compound, particularly in the form of fungicide com

Optimisation of 2-(N-phenyl carboxamide) triazolopyrimidine antimalarials with moderate to slow acting erythrocytic stage activity

Malaria is a devastating parasitic disease caused by parasites from the genus Plasmodium. Therapeutic resistance has been reported against all clinically available antimalarials, threatening our ability to control the disease and therefore there is an ongoing need for the development of novel antimalarials. Towards this goal, we identified the 2-(N-phenyl carboxamide) triazolopyrimidine class from a high throughput screen of the Janssen Jumpstarter library against the asexual stages of the P. falciparum parasite. Here we describe the structure activity relationship of the identified class and the optimisation of asexual stage activity while maintaining selectivity against the human HepG2 cell line. The most potent analogues from this study were shown to exhibit equipotent activity against P. falciparum multidrug resistant strains and P. knowlesi asexual parasites. Asexual stage phenotyping studies determined the triazolopyrimidine class arrests parasites at the trophozoite stage, but it is likely these parasites are still metabolically active until the second asexual cycle, and thus have a moderate to slow onset of action. Non-NADPH dependent degradation of the central carboxamide and low aqueous solubility was observed in in vitro ADME profiling. A significant challenge remains to correct these liabilities for further advancement of the 2-(N-phenyl carboxamide) triazolopyrimidine scaffold as a potential moderate to slow acting partner in a curative or prophylactic antimalarial treatment.

Electrochemical Synthesis of Benzo[ d]imidazole via Intramolecular C(sp3)-H Amination

An electrochemical dehydrogenative amination for the synthesis of benzimidazoles was developed. This electrosynthesis method could address the limitations of the C(sp3)-H intramolecular amination synthesis reaction and provide novel access to obtain 1,2-disubstituted benzimidazoles without transition metals and oxidants. Under undivided electrolytic conditions, various benzimidazole derivatives could be synthesized, exhibiting functional group tolerance.